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Does Oleic Acid Hold the Key to α-Synuclein Toxicity?

RESEARCH NEWS 2018-12-10 Research News Dieticians recommend consuming mostly unsaturated fats for cardiovascular health and a slim waistline. Now, in a surprising twist, researchers claim one such fat, oleic acid, may worsen α-synuclein pathology. In the December 4 Molecular Cell ...

First Round of Awards from Chan Zuckerberg Initiative Announced

COMMUNITY NEWS 2018-12-07 Community News Earlier this year, the Chan Zuckerberg Initiative (CZI) dove into the field of neurodegenerative disease research, launching the Neurodegenerative Challenge Network to promote cross-disciplinary basic science research (Feb 2018 news). On ...

Neurofilament Light: A Universal Mark of Neurodegeneration

RESEARCH NEWS 2018-12-07 Research News A paper in the December 3 JAMA Neurology adds yet more evidence that neurofilament light (NfL) protein is a general biomarker of neurodegeneration. Scientists led by Bob Olsson and Erik Portelius, University of Gothenburg, Sweden, found ...

A Proteomics Dive into Cause of Frontotemporal Dementia

CONFERENCE COVERAGE 2018-12-06 Conference Coverage If DNA makes RNA makes protein, then genomic variants make RNA make protein … make disease. While scientists have found polymorphisms that associate with various forms of frontotemporal dementia, deciphering how they perturb proteins ...

Tracking Onset and Progression of Frontotemporal Dementia

CONFERENCE COVERAGE 2018-12-05 Conference Coverage Now that initiatives such as ARTFL and LEFFTDS have gathered sufficient numbers of participants for scientists to tackle prevention and treatment trials (see Part 2 of this conference series), the need for better tools to track onset ...

Natural History Studies Provide Foundation for FTD Research

CONFERENCE COVERAGE 2018-12-05 Conference Coverage At the 11th International Congress on Frontotemporal Dementia, held November 11–14 in Sydney, no two acronyms were heard more than ARTFL and LEFFTDS. For those readers who have not built them into their FTD vocabulary yet, Advancing ...

11th ICFTD Meeting in Sydney Sorts Out Clinical Subtypes

CONFERENCE COVERAGE 2018-12-04 Conference Coverage Indigenous Australian people opened the 11th International Conference on Frontotemporal Dementia at the International Convention Center, Sydney, November 11–14. Koomurri performers welcomed more than 600 attendees from 37 countries. ...

Going the Distance: FUS Travels to Terminals, Drops Off RNA

CONFERENCE COVERAGE 2018-12-02 Conference Coverage Following their transcription from the genome, RNA messages exit the nucleus and enter the cytoplasm, sometimes traveling vast distances before they are finally translated into protein. RNA-binding proteins are helping hands on this ...

Beyond the Nucleus: TDP-43 Sticks Together, For Better or Worse

CONFERENCE COVERAGE 2018-12-01 Conference Coverage Similar to a newborn human, nascent RNA transcripts need a lot of coddling before they realize their purpose in life (that is, translation into protein). It takes a village of RNA-binding proteins to accomplish this. They see to the ...

Pig Model of ALS Mimics Human Disease

RESEARCH NEWS 2018-11-30 Research News In the November 21 Neurobiology of Disease, researchers led by Cristiano Corona, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Turin, Italy, characterize the ALS-like signs and symptoms seen in pigs that ...

Imaging Data Resurrects Abandoned Parkinson’s Gene Therapy

RESEARCH NEWS 2018-11-30 Research News Researchers often do not understand exactly how treatments produce benefits. Take a recent gene therapy for Parkinson’s disease. It was intended to dampen excess activity in the subthalamic nucleus, mimicking the effect of deep brain ...

Could an Aspirin a Day Keep Multiple Sclerosis at Bay?

RESEARCH NEWS 2018-11-29 Research News People take aspirin for pain, fever, and even in hopes of warding off a heart attack. Could this old, over-the-counter pill also help control multiple sclerosis? A November 27 report in Science Signaling suggests as much—in mice. Scientists ...

Which Are the Right Tests to Satisfy New FDA Guidance?

CONFERENCE COVERAGE 2018-11-27 Conference Coverage As researchers push toward testing Alzheimer’s drugs at presymptomatic stages, the hurdle before them—how to show efficacy and get a drug approved—looks different than before. In its February 2018 draft guidance for industry, the U.S. ...

Progranulin: A Mark of Worsening Alzheimer’s?

RESEARCH NEWS 2018-11-27 Research News Progranulin, a microglial protein typically associated with frontotemporal dementia, may also play a role in Alzheimer’s. That’s according to a November 27 paper in the EMBO Journal. Scientists led by Christian Haass, Ludwig-Maximilians ...

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