275 RESULTS
RESEARCH NEWS 2019-01-04 Research News In the weeks following a stroke, regulatory T cells stream into the brain. What exactly do they do there? Scientists led by Akihiko Yoshimura, Keio University School of Medicine, Tokyo, report in the January 2 Nature that these cells dampen
RESEARCH NEWS 2018-12-28 Research News Once again, it’s time to reflect on the preceding 12 months. Despite the 2025 deadline for effective therapy that has been set by the National Alzheimer’s Plan and the World Dementia Council, 2018 brought no drug approvals or Phase 3 breakth
RESEARCH NEWS 2018-12-28 Research News A person’s genetic background promotes Alzheimer’s or protects against it, but existing mouse models in genetically identical strains ignore this aspect of a multigenic disease in humans, an outbred population. Is this why mouse treatment st
RESEARCH NEWS 2018-12-24 Research News Cerebrospinal fluid tau is an established Alzheimer’s disease biomarker, but efforts to develop a blood test for tau have been hampered by exceedingly low concentrations of the protein there. At least, until now, claims a paper published in
RESEARCH NEWS 2018-12-21 Research News Many genetic variants that lead to neurodegenerative disease are rare, and so scientists cannot obtain enough brain tissue for mechanistic studies. Researchers led by Celeste Karch, Carlos Cruchaga, and Oscar Harari at Washington University
RESEARCH NEWS 2018-12-21 Research News Just last month, gene expression profiling of individual mouse microglia showcased diverse phenotypes that reflected the cells’ multifaceted roles in development and immune surveillance. Efforts to do the same with human microglia have lagge
CONFERENCE COVERAGE 2018-12-21 Conference Coverage The circadian clock—the body’s molecular timekeeper—is best known for tuning our sleep, metabolism, digestion, and body temperature to the cycles of dark and light. Yet it controls other functions, as well. At the Society for Neuroscie
RESEARCH NEWS 2018-12-21 Research News Up to now, toxic TDP-43 aggregates have been hard to isolate, making them difficult to characterize physically. A new technique from the lab of Magdalini Polymenidou, University of Zurich, may help. Called SarkoSpin, it separates the aggrega
CONFERENCE COVERAGE 2018-12-20 Conference Coverage Part 2 of a two-part story. Click here for Part 1. Long before neurons die in the Alzheimer’s brain, their synapses go kaput. Both Aβ and tau pathology have been blamed for this synaptic breakdown, but at the Society for Neuroscience m
CONFERENCE COVERAGE 2018-12-20 Conference Coverage Part 1 of a two-part story. Click here for Part 2. Tau comes in many forms, and calls many locations home, both inside and outside of cells. Which is the one that wreaks damage to neurons, and where exactly does it reside? Researchers
CONFERENCE COVERAGE 2018-12-14 Conference Coverage Never mind the wrinkles and gray hair. Embattled microglia, waning neurogenesis, and withering synapses are also part and parcel of the aging process. What drives those seemingly inexorable changes inside the brain? At the Society for
RESEARCH NEWS 2018-12-14 Research News Researchers have strengthened the case that certain medical procedures can transfer amyloid pathology between people. John Collinge and Sebastian Brandner at University College London previously reported finding amyloid plaques and cerebral
RESEARCH NEWS 2018-12-14 Research News For a PET ligand, validation is literally a matter of life and death. Its reliability rides on a direct comparison of tracer uptake in a living person with his or her autopsy result. In the December 3 JAMA Neurology, Ruben Smith and Oskar Ha
RESEARCH NEWS 2018-12-13 Research News Genetic studies of late-onset Alzheimer’s point to variations in the function of the innate immune system—and its CNS cadre, the microglia. Why would immune genes determine whether a person will get the disease? Perhaps because the innate im
CONFERENCE COVERAGE 2018-12-12 Conference Coverage On December 5, global leaders came together at the Wellcome Trust offices in London for a meeting of the World Dementia Council, the body charged with leading the global response to dementia and coordinating international efforts towar
