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Neurofilament in Blood Foretells Early Onset Alzheimer’s

RESEARCH NEWS 2019-01-21 Research News A paper published online today in Nature Medicine finds that in familial Alzheimer’s disease, blood levels of neurofilament light (NfL) rise 16 years before the predicted age of onset. Scientists led by Mathias Jucker, German Center for ...

Invasion of the Microtubules: Mutant Tau Deforms Neuronal Nuclei

RESEARCH NEWS 2019-01-19 Research News A paper in the January 15 Cell Reports suggests that tauopathies cause defects in nucleocytoplasmic transport. Scientists led by Rick Livesey, University College London, report that mutated tau gives rise to microtubules that prod neuronal ...

Deadline to Weigh In on New Biomarker Guidance Approaches

COMMUNITY NEWS 2019-01-18 Community News The development of biomarkers for Alzheimer’s and other neurodegenerative diseases is accelerating rapidly, with blood tests and new fluid and imaging markers on the horizon (Aug 2018 news; Nov 2018 news; Dec 2018 news). However, developers ...

Microtubule Regulator Connects TDP-43 to Axonal Dysfunction

RESEARCH NEWS 2019-01-18 Research News Nearly all cases of amyotrophic lateral sclerosis, and half of frontotemporal dementia ones, are marked by deposits of the RNA-binding protein TDP-43, yet researchers still have little idea how this pathology relates to neurodegeneration. ...

Could the Purported Muscle Exercise Hormone, Irisin, Jog Memory?

RESEARCH NEWS 2019-01-16 Research News Physical activity may improve cognition, and a paper in the January 8 Nature Medicine makes the case that a peptide shed from muscles during exercise might be responsible. Researchers led by Fernanda De Felice of Federal University of Rio De ...

First In Vivo Look at Amyloidosis Sparked by Dural Grafts

RESEARCH NEWS 2019-01-16 Research News Evidence for the transmission of Aβ seeds between people keeps accumulating. In the December 31 Annals of Neurology, researchers led by David Werring at University College London describe the cases of three adults with early onset cerebral ...

Secreted APP Binds GABA-B Receptors, Blocks Neurotransmitter Release

RESEARCH NEWS 2019-01-13 Research News Though Aβ tends to hog the research spotlight, scientists have steadily built a case for the importance of another APP fragment—secreted APP. Now, a paper in the January 11 Science explains how it tweaks synaptic transmission. Researchers ...

Tau, More than Aβ, Affects Sleep Early in Alzheimer’s

RESEARCH NEWS 2019-01-12 Research News Mounting evidence suggests a link between β-amyloid and disrupted sleep. Does the same hold true for tau? Yes, according to a paper published in the January 9 Science Translational Medicine. Using PET imaging, scientists led by Brendan Lucey ...

Do Alzheimer’s Biomarkers Vary by Race?

RESEARCH NEWS 2019-01-11 Research News Most of the research on Alzheimer’s biomarkers to date has been done in predominantly white populations, but a few small studies have hinted at possible racial differences. A paper in the January 7 JAMA Neurology supports this idea. ...

CryoEM γ-Secretase Structures Nail APP, Notch Binding

RESEARCH NEWS 2019-01-11 Research News Targeting the γ-secretase protease to prevent Alzheimer’s disease would require surgical precision to shut down Aβ42 production while allowing the non-pathogenic processing of amyloid precursor protein (APP) and other important substrates to ...

New PET Tracer Selectively Lights Up Activated Microglia in Brain

RESEARCH NEWS 2019-01-11 Research News Researchers would like better ways to image inflammation in the brain. Currently, some use PET tracers targeting the mitochondrial transporter TSPO to measure active microglia, but these ligands are plagued by poor specificity and high ...

Without TREM2, Plaques Grow Fast in Mice, Have Less ApoE

RESEARCH NEWS 2019-01-07 Research News A paper in the January 7 Nature Neuroscience reports that in mice lacking TREM2, Aβ extracts seed new plaques faster than they do in control mice. Scientists led by Christian Haass, Ludwig-Maximilians University, Munich, and Melanie Meyer ...

Autophagy, Inflammation, Degeneration: Parsing an Unholy Trinity

RESEARCH NEWS 2019-01-07 Research News In neurodegenerative disease, inflammation runs rampant in the brain. But is this a cause or a consequence of pathology? Researchers led by Edward Giniger at the National Institute of Neurological Disorders and Stroke in Bethesda, Maryland, ...

GABA-A Receptor Structures Point to Drug Mechanisms

RESEARCH NEWS 2019-01-04 Research News What do sedatives, general anesthetics, anti-anxiety drugs, alcohol, numerous recreational drugs, and allopregnanolone, a neurosteroid being tested in Alzheimer’s trials, have in common? They all tweak the activity of GABA-A receptors. When ...

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