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Alzheimer’s Association Report Argues for Cognitive Screening

COMMUNITY NEWS 2019-03-08 Community News On March 5, the Alzheimer's Association released its annual Facts and Figures report, a compilation of the latest statistics on Alzheimer’s disease in the U.S. Besides summing up prevalence, mortality and morbidity, and costs of ...

Paper Alerts: Massive GWAS Studies Published

RESEARCH NEWS 2019-03-02 Research News On February 28 in Nature Genetics online, geneticists from the International Genomics of Alzheimer’s Project published the largest genome-wide association meta-analysis to date. Brian Kunkle, University of Miami Miller School of Medicine, ...

Stress Granules: No Incubator for Inclusions, After All?

RESEARCH NEWS 2019-03-01 Research News TDP-43 proteinopathy rears its ugly head in most patients with amyotrophic lateral sclerosis and nearly half of those with frontotemporal dementia, not to mention many cases of Alzheimer’s disease and traumatic brain injury. Still, it’s been ...

Take With a Grain of Salt: Mitigating Aβ Pathology With Sodium Rutin

RESEARCH NEWS 2019-03-01 Research News Want more evidence of the importance of microglia for Alzheimer’s disease? A study in the February 27 Science Advances suggests that spicing up the metabolism of these cells can tamp down Alzheimer’s pathology. Researchers led by Zengqiang ...

Rogue Gene Networks Track with Neurodegeneration Across Diseases

RESEARCH NEWS 2019-03-01 Research News A sporadic case of neurodegenerative disease likely represents the culmination of myriad gene-expression changes in the brain. How to make sense of the chaos, let alone restore order? In the January Nature Medicine, researchers led by Daniel ...

Single-Cell Profiling Maps Human Microglial Diversity, Flexibility

RESEARCH NEWS 2019-02-23 Research News A first go at cataloging gene expression in individual microglia from human brain reveals a picture similar to that seen in mice: Microglia come in many flavors, morphing over time with age and brain location, and in response to disease. In ...

Nixing Neuron Receptor Improves Recovery from Stroke, Trauma

RESEARCH NEWS 2019-02-22 Research News Recovery from stroke can be slow-going. Neurons struggle to sprout new axons, make new dendritic spines, and form new synapses. Is there any way, besides standard physical therapy, to help the process along? A February 21 paper in Cell ...

Viral Vectors Trigger Robust Tauopathy in Brain Slices

RESEARCH NEWS 2019-02-22 Research News Research on neurodegenerative disease is advancing slowly in part because most models aren’t very good. In the February 15 Journal of Experimental Medicine, researchers led by Todd Golde at the University of Florida, Gainesville, debuted a ...

Midlife Peripheral Inflammation May Drive Later Cognitive Decline

RESEARCH NEWS 2019-02-20 Research News A decades-long study of more than 12,000 participants suggests that midlife inflammation drives cognitive decline in old age. Scientists led by Rebecca Gottesman, Johns Hopkins Medicine, Baltimore, report in the February 13 Neurology that ...

In Small Trial, EH301 Appears to Halt Progression of ALS

RESEARCH NEWS 2019-02-18 Research News Could a dietary supplement marketed directly to consumers moonlight as an effective treatment for ALS? It is within the realm of possibility, according to the results of a small Phase 1 pilot study testing EH301 in people with the disease. ...

Immune Cells Clog Capillaries in Mice, Disrupt Memory

RESEARCH NEWS 2019-02-15 Research News One of the characteristic features of Alzheimer’s disease is reduced blood flow in the brain. What brings it down? A paper in the February 11 Nature Neuroscience suggests that white blood cells can clog up the works. Scientists led by Chris ...

Studies Point to DNA Difficulties in ALS/FTD

RESEARCH NEWS 2019-02-15 Research News Three studies published this week on the etiology of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) spotlight a cell compartment that is often overlooked. They focus squarely on the nucleus, specifically the integrity of ...

Could Disposing of Damaged Mitochondria Treat Alzheimer’s Disease?

RESEARCH NEWS 2019-02-15 Research News Malfunctioning mitochondria accumulate in the Alzheimer’s disease brain. Could they be purged? In the February 11 Nature Neuroscience, researchers led by Vilhelm Bohr at the National Institute on Aging, Baltimore, argue that these defective ...

Clotting Protein from Blood Incites Microglia, and Synapses Die

RESEARCH NEWS 2019-02-08 Research News A damaged and leaky blood-brain barrier contributes to dementia, but just how has not been clear. Previous work implicated the clotting protein fibrinogen, which, when it penetrates the brain and coagulates, activates microglia and leads to ...

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