Epilogue on Edonerpic: It Does Not Work in Alzheimer’s

RESEARCH NEWS 2019-07-10 Research News The drug edonerpic maleate failed to slow cognitive decline in Alzheimer’s patients, according to a paper published online July 8 in JAMA Neurology. Scientists led by Lon Schneider, University of Southern California, Los Angeles, reported ...

Invading T Cells Quash Neurogenesis

RESEARCH NEWS 2019-07-06 Research News Adult mammalian brains eke out limited numbers of new neurons in select regions, but over time, even that production dwindles. Why is unclear. New evidence from the lab of Anne Brunet, Stanford University, California, suggests invading ...

Settlement Reached Between UCSD and USC, Paul Aisen

COMMUNITY NEWS 2019-07-05 Community News A bitter dispute that pitted the University of California, San Diego, against the University of Southern California and Paul Aisen has been settled. USC will pay UCSD $50 million to compensate for its sudden recruitment of Aisen and other ...

Dopaminergic Neurons Conjured from Astrocytes Restore Motion

CONFERENCE COVERAGE 2019-07-05 Conference Coverage Astrocytes are devoted nurturers of neurons—facilitating synaptic transmission, maintaining the blood-brain barrier, and repairing injuries are but a few of their ministrations. As if that weren’t enough, scientists described an ...

Prostate Cancer Therapy Makes Dementia More Likely

RESEARCH NEWS 2019-07-03 Research News In the largest U.S. study to date on androgen-deprivation therapy and dementia, researchers led by Ravishankar Jayadevappa, University of Pennsylvania, Philadelphia, found that among older men with prostate cancer, those who received this ...

Down to Sex? Boy and Girl Microglia Respond Differently

CONFERENCE COVERAGE 2019-07-02 Conference Coverage Some microglia are from Mars; others from Venus. Well, no. But in some scenarios, to which sex a microglial cell belongs appears to hold some sway over how it responds. Consider tau. At a joint Keystone symposia—Neurodegenerative ...

TREM2, Microglia Dampen Dangerous Liaisons Between Aβ and Tau

CONFERENCE COVERAGE 2019-07-02 Conference Coverage That microglia play a central role in neurodegenerative disease has become a premise; it’s no longer a question. The questions are all about the how. This was abundantly clear at joint symposia held June 16–21 in Keystone, Colorado. At ...

Does Serotonin Pathology Foreshadow Parkinson’s Disease?

RESEARCH NEWS 2019-06-28 Research News Parkinson’s disease inflicts brain damage years before patients begin shaking, slowing down, and feeling stiff. What happens before motor symptoms surface, however, remains murky. In a study in the June 19 Lancet Neurology, researchers led ...

Gently Used: Can Recycled Microglia Receptors Prevent Plaque?

RESEARCH NEWS 2019-06-28 Research News Microglia do much of the heavy lifting when it comes to removing Aβ, but how do they do it? Researchers led by Douglas Green, St. Jude Children’s Research Hospital, Memphis, Tennessee, have identified an endocytic recycling process by which ...

New Tool: Microglia-Specific Reporter Mice, With Choice of Colors

RESEARCH NEWS 2019-06-26 Research News Microglia, the ever-changing resident immune cells of the central nervous system, have come under intense scrutiny for their role in Alzheimer’s disease and other neuroinflammatory conditions. Tracking these famously elusive cells just got ...

Meet medRχiv: A New Preprint Server for Health Research

COMMUNITY NEWS 2019-06-25 Community News Today the co-founders of the preprint server bioRχiv, together with The BMJ in London and Yale University in New Haven, Connecticut, launch a sister repository for research papers in the medical sciences. Called medRχiv, this free, ...

Drawing Closer: Alzheimer’s Blood Test for Primary Care

RESEARCH NEWS 2019-06-24 Research News In today’s JAMA Neurology, researchers led by Oskar Hansson, Lund University, Sweden, report how a fully automated immunoassay for plasma Aβ performed when they put it through its paces. Roche Diagnostic’s Elecsys system predicted Aβ ...

NfL: Useful in Differential Diagnosis?

RESEARCH NEWS 2019-06-22 Research News In a comprehensive meta-analysis, scientists led by Claire Bridel, VU University Medical Center, Amsterdam, compared levels of neurofilament light in the cerebrospinal fluid of healthy controls and patients covering a spectrum of ...

Aβ Acts Through Pericytes to Throttle Brain Blood Flow

RESEARCH NEWS 2019-06-22 Research News In Alzheimer’s disease, blood flows sluggishly through the brain, partly because Aβ provokes small blood vessels to constrict. In the June 20 Science, researchers led by David Attwell at University College London blame this on pericytes, ...

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