RESEARCH NEWS 2018-10-02 Research News A small-molecule inhibitor of caspase-1 has a seemingly large effect in a mouse model of Alzheimer’s disease. Researchers led by Andréa LeBlanc of McGill University in Montreal reported in the September 25 Nature Communications that VX-765 r
RESEARCH NEWS 2018-09-28 Research News In Alzheimer’s disease, tau tangles correlate closely with neurodegeneration, but how they work their mischief remains unclear. Two papers now link tau to the buildup of senescent cells in the brain. These aged, sick cells can neither divide
RESEARCH NEWS 2018-09-28 Research News A putative amyloid-lowering agent, the blood pressure drug nilvadipine has proven ineffective in people with mild to moderate Alzheimer’s disease in a Phase 3 trial. In the September 24 PLoS Medicine, researchers led by Brian Lawlor at St. J
RESEARCH NEWS 2018-09-28 Research News An RNA-binding protein never before linked to neurodegeneration may conspire with ataxin-2 to decimate the neuronal transcriptome. According to a September 7 paper in Nature Communications, the cytoplasmic Staufen1 accrues in neurons when mu
RESEARCH NEWS 2018-09-27 Research News People with autosomal-dominant mutations in APP or presenilin genes develop early onset Alzheimer’s disease. Could a healthy lifestyle mitigate this genetic misfortune? A new study indicates that it may. A cross-sectional study of participan
RESEARCH NEWS 2018-09-25 Research News Kiss those smooth, sigmoidal curves goodbye, and embrace the jumbled complexity of spaghetti plots. Longitudinal data charting the trajectories of a bevy of biomarkers in people with autosomal-dominant AD (ADAD) was published September 20 in
RESEARCH NEWS 2018-09-21 Research News Most tau PET tracers detect only the type of misfolded tau found in Alzheimer’s disease. In the September 18 JAMA, researchers led by Rik Ossenkoppele at VU University Medical Center, Amsterdam, and Oskar Hansson at Lund University, Sweden,
RESEARCH NEWS 2018-09-21 Research News BACE1 knockout mice have more than their fair share of problems, but is it because they lack the enzyme during development or during adulthood? New conditional knockouts from the lab of Robert Vassar, Northwestern University, Chicago, sugges