Not Just Motoneurons: Sensory Neurons Suffer Effects of ALS

RESEARCH NEWS 2018-11-16 Research News A cell biology study adds evidence that sensory neurons, not just motoneurons, take a direct hit in amyotrophic lateral sclerosis (ALS). Scientists led by Gregorio Valdez, Virginia Tech Carilion Research Institute, Roanoke, report that ...

Is NfL the New 'N' in A/T/N Classification of Alzheimer’s?

RESEARCH NEWS 2018-11-15 Research News Neurofilament light (NfL) measured in cerebrospinal fluid predicts mild cognitive impairment better than other CSF indicators of neurodegeneration, according to the November 12 JAMA Neurology. Scientists led by Michelle Mielke, Mayo Clinic, ...

Amyloid PET Aids Diagnosis. But Could CSF Do Just as Well?

CONFERENCE COVERAGE 2018-11-14 Conference Coverage Clinicians have been eagerly awaiting results of the enormous Imaging Dementia–Evidence for Amyloid Scanning  (IDEAS) study, which may determine whether amyloid scans will be covered by insurance. Preliminary findings previously ...

Toxic Stew of Aβ Dimers Hides Out in Human Plaques

CONFERENCE COVERAGE 2018-11-13 Conference Coverage The question of which Aβ species are toxic in Alzheimer’s disease is often asked, and the answer has been maddeningly elusive. At the Society for Neuroscience annual meeting in San Diego November 3–7, the lab of Dominic Walsh, Brigham ...

Blood Tests for Amyloid Step Out at CTAD

CONFERENCE COVERAGE 2018-11-09 Conference Coverage It seems blood tests for Aβ have moved off the wish list and are becoming reality—almost. Building a knowledge base for plasma measures as a proxy for brain amyloid, multiple methods applied to different research cohorts are now ...

Can Clinical Trials and Longitudinal Studies Crack Rare Tauopathies?

CONFERENCE COVERAGE 2018-11-08 Conference Coverage When scientists gathered in London on October 25–26 for the first International Research Symposium on progressive supranuclear palsy and corticobasal degeneration, it was obvious that momentum was building in the study of these rare ...

International Symposium Puts PSP/CBD on the Map

CONFERENCE COVERAGE 2018-11-08 Conference Coverage Progressive supranuclear palsy and corticobasal degeneration are rare, poorly understood tauopathies with a broad array of symptoms and subtypes. What causes them? How to prevent, diagnose, track, and treat them? On October 25 and 26, ...

NfL in Blood Foretells Poor Brain Health After the Heart Stops

RESEARCH NEWS 2018-11-07 Research News Neurofilament light protein might be useful in cardiovascular emergency medicine, not just in neurology. A blood test could allow doctors to predict brain damage after a cardiac arrest, according to an October 29 paper in JAMA Neurology. ...

More Private Funding for Alzheimer’s Research

COMMUNITY NEWS 2018-11-05 Community News Texas industrialist James Truchard has donated $5 million to the University of Texas at San Antonio (UTSA) to help piece together the complex puzzle of Alzheimer’s disease. The announcement, made today at the Society for Neuroscience’s ...

Second Look at BAN2401 Data Still Positive, Despite Snafu

CONFERENCE COVERAGE 2018-11-02 Conference Coverage Researchers got a fuller view of the data coming out of the Phase 2b trial of the anti-Aβ BAN2401 antibody at the 11th Clinical Trials on Alzheimer Disease conference, which convened in Barcelona, Spain, from October 24–27. Eisai’s ...

Bump in the Road or Disaster? BACE Inhibitors Worsen Cognition

CONFERENCE COVERAGE 2018-11-02 Conference Coverage Currently, hopes for an Alzheimer’s prevention therapy hang on BACE inhibitors that squelch generation of Aβ peptides. When these compounds failed to slow cognitive decline in symptomatic patients, researchers argued that they might ...

TDP-43 Joins Cell-To-Cell Propagation Gang

RESEARCH NEWS 2018-10-29 Research News New data suggest that TDP-43 from diseased human brains propagates along neuronal connections in mice. According to a report in the October 11 Nature Communications, extracts containing pathological TDP-43 from postmortem brains of patients ...

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