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Single-Cell Profiling Maps Human Microglial Diversity, Flexibility

RESEARCH NEWS 2019-02-23 Research News A first go at cataloging gene expression in individual microglia from human brain reveals a picture similar to that seen in mice: Microglia come in many flavors, morphing over time with age and brain location, and in response to disease. In ...

Nixing Neuron Receptor Improves Recovery from Stroke, Trauma

RESEARCH NEWS 2019-02-22 Research News Recovery from stroke can be slow-going. Neurons struggle to sprout new axons, make new dendritic spines, and form new synapses. Is there any way, besides standard physical therapy, to help the process along? A February 21 paper in Cell ...

Viral Vectors Trigger Robust Tauopathy in Brain Slices

RESEARCH NEWS 2019-02-22 Research News Research on neurodegenerative disease is advancing slowly in part because most models aren’t very good. In the February 15 Journal of Experimental Medicine, researchers led by Todd Golde at the University of Florida, Gainesville, debuted a ...

Midlife Peripheral Inflammation May Drive Later Cognitive Decline

RESEARCH NEWS 2019-02-20 Research News A decades-long study of more than 12,000 participants suggests that midlife inflammation drives cognitive decline in old age. Scientists led by Rebecca Gottesman, Johns Hopkins Medicine, Baltimore, report in the February 13 Neurology that ...

In Small Trial, EH301 Appears to Halt Progression of ALS

RESEARCH NEWS 2019-02-18 Research News Could a dietary supplement marketed directly to consumers moonlight as an effective treatment for ALS? It is within the realm of possibility, according to the results of a small Phase 1 pilot study testing EH301 in people with the disease. ...

Immune Cells Clog Capillaries in Mice, Disrupt Memory

RESEARCH NEWS 2019-02-15 Research News One of the characteristic features of Alzheimer’s disease is reduced blood flow in the brain. What brings it down? A paper in the February 11 Nature Neuroscience suggests that white blood cells can clog up the works. Scientists led by Chris ...

Studies Point to DNA Difficulties in ALS/FTD

RESEARCH NEWS 2019-02-15 Research News Three studies published this week on the etiology of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) spotlight a cell compartment that is often overlooked. They focus squarely on the nucleus, specifically the integrity of ...

Could Disposing of Damaged Mitochondria Treat Alzheimer’s Disease?

RESEARCH NEWS 2019-02-15 Research News Malfunctioning mitochondria accumulate in the Alzheimer’s disease brain. Could they be purged? In the February 11 Nature Neuroscience, researchers led by Vilhelm Bohr at the National Institute on Aging, Baltimore, argue that these defective ...

Clotting Protein from Blood Incites Microglia, and Synapses Die

RESEARCH NEWS 2019-02-08 Research News A damaged and leaky blood-brain barrier contributes to dementia, but just how has not been clear. Previous work implicated the clotting protein fibrinogen, which, when it penetrates the brain and coagulates, activates microglia and leads to ...

Is a Woman’s Brain More Susceptible to Tau Pathology?

RESEARCH NEWS 2019-02-08 Research News Some studies of cerebrospinal fluid biomarkers suggest that women accumulate more tau pathology early in Alzheimer’s disease than do men. In the February 4 JAMA Neurology, researchers led by Rachel Buckley and Reisa Sperling at Massachusetts ...

Panel of Blood Markers Signals Amyloid in Brain

RESEARCH NEWS 2019-02-07 Research News Yet another potential blood test for amyloid pathology has entered the ring. Using mass spectrometry to take an unbiased look at plasma proteins, researchers led by Abdul Hye, King’s College London, found a panel of biomarkers that predicted ...

Cholesteryl Esters Hobble Proteasomes, Increase p-Tau

RESEARCH NEWS 2019-02-07 Research News A cholesterol metabolite boosts accumulation of phosphorylated tau, according to a paper in the January 16 Cell Stem Cell. Researchers led by Lawrence Goldstein at the University of California, San Diego, reported that cholesteryl esters ...

Cancer Treatment Takes Aim at Tauopathy

RESEARCH NEWS 2019-02-05 Research News Three years ago in a high-profile paper, researchers led by Michal Schwartz at the Weizmann Institute of Science in Rehovot, Israel, deployed an immune-boosting approach pioneered for cancer in a mouse model of Alzheimer’s disease. The ...

In Alzheimer’s, Too Little REST Spurs Too Much Neurogenesis

RESEARCH NEWS 2019-02-04 Research News A paper published January 29 in Cell Reports claims that among the earliest changes in sporadic Alzheimer’s disease (SAD) are genetic changes that lead to premature neurogenesis. Scientists led by Bruce Yankner, Harvard Medical School, found ...

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