RESEARCH NEWS 2019-01-11 Research News Most of the research on Alzheimer’s biomarkers to date has been done in predominantly white populations, but a few small studies have hinted at possible racial differences. A paper in the January 7 JAMA Neurology supports this idea. Research
RESEARCH NEWS 2019-01-11 Research News Targeting the γ-secretase protease to prevent Alzheimer’s disease would require surgical precision to shut down Aβ42 production while allowing the non-pathogenic processing of amyloid precursor protein (APP) and other important substrates to
RESEARCH NEWS 2019-01-11 Research News Researchers would like better ways to image inflammation in the brain. Currently, some use PET tracers targeting the mitochondrial transporter TSPO to measure active microglia, but these ligands are plagued by poor specificity and high varia
RESEARCH NEWS 2019-01-07 Research News A paper in the January 7 Nature Neuroscience reports that in mice lacking TREM2, Aβ extracts seed new plaques faster than they do in control mice. Scientists led by Christian Haass, Ludwig-Maximilians University, Munich, and Melanie Meyer-Lü
RESEARCH NEWS 2019-01-07 Research News In neurodegenerative disease, inflammation runs rampant in the brain. But is this a cause or a consequence of pathology? Researchers led by Edward Giniger at the National Institute of Neurological Disorders and Stroke in Bethesda, Maryland,
RESEARCH NEWS 2019-01-04 Research News What do sedatives, general anesthetics, anti-anxiety drugs, alcohol, numerous recreational drugs, and allopregnanolone, a neurosteroid being tested in Alzheimer’s trials, have in common? They all tweak the activity of GABA-A receptors. When
RESEARCH NEWS 2019-01-04 Research News In the weeks following a stroke, regulatory T cells stream into the brain. What exactly do they do there? Scientists led by Akihiko Yoshimura, Keio University School of Medicine, Tokyo, report in the January 2 Nature that these cells dampen
RESEARCH NEWS 2018-12-28 Research News Once again, it’s time to reflect on the preceding 12 months. Despite the 2025 deadline for effective therapy that has been set by the National Alzheimer’s Plan and the World Dementia Council, 2018 brought no drug approvals or Phase 3 breakth
RESEARCH NEWS 2018-12-28 Research News A person’s genetic background promotes Alzheimer’s or protects against it, but existing mouse models in genetically identical strains ignore this aspect of a multigenic disease in humans, an outbred population. Is this why mouse treatment st
RESEARCH NEWS 2018-12-24 Research News Cerebrospinal fluid tau is an established Alzheimer’s disease biomarker, but efforts to develop a blood test for tau have been hampered by exceedingly low concentrations of the protein there. At least, until now, claims a paper published in
RESEARCH NEWS 2018-12-21 Research News Many genetic variants that lead to neurodegenerative disease are rare, and so scientists cannot obtain enough brain tissue for mechanistic studies. Researchers led by Celeste Karch, Carlos Cruchaga, and Oscar Harari at Washington University
RESEARCH NEWS 2018-12-21 Research News Just last month, gene expression profiling of individual mouse microglia showcased diverse phenotypes that reflected the cells’ multifaceted roles in development and immune surveillance. Efforts to do the same with human microglia have lagge
CONFERENCE COVERAGE 2018-12-21 Conference Coverage The circadian clock—the body’s molecular timekeeper—is best known for tuning our sleep, metabolism, digestion, and body temperature to the cycles of dark and light. Yet it controls other functions, as well. At the Society for Neuroscie
RESEARCH NEWS 2018-12-21 Research News Up to now, toxic TDP-43 aggregates have been hard to isolate, making them difficult to characterize physically. A new technique from the lab of Magdalini Polymenidou, University of Zurich, may help. Called SarkoSpin, it separates the aggrega
CONFERENCE COVERAGE 2018-12-20 Conference Coverage Part 2 of a two-part story. Click here for Part 1. Long before neurons die in the Alzheimer’s brain, their synapses go kaput. Both Aβ and tau pathology have been blamed for this synaptic breakdown, but at the Society for Neuroscience m