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RESEARCH NEWS 2023-11-03 Research News Bright spots called white-matter hyperintensities (WMHs) often appear on MRI scans of people with familial or sporadic Alzheimer’s disease, and they tend to intensify as the disease progresses. Some scientists think they reflect cerebrovascu
RESEARCH NEWS 2023-11-03 Research News Because certain variants in TREM2 increase a person's risk of developing Alzheimer’s disease, how this microglial receptor influences AD pathology is an area of intense investigation. Now, researchers led by Zhentao Zhang, Renmin Hospit
CONFERENCE COVERAGE 2023-10-27 Conference Coverage Inflammation can be a helpful response to the common cold or the bite of an insect, but dangerous if it persists. In neurodegeneration, chronic micro- and astrogliosis spell trouble for the brain. Does it have to be that way? Over the
RESEARCH NEWS 2023-10-26 Research News Though APOE4 is the strongest genetic risk factor for sporadic Alzheimer’s disease, scientists have struggled for decades to figure out how it affects the cells of the brain. For microglia, at least, there may be some clarity. In the Septem
RESEARCH NEWS 2023-10-24 Research News People with ApoE3 Christchurch variant stave off even autosomal-dominant Alzheimer’s disease by keeping neurofibrillary tangles at bay. Could people born without this protective mutation reap its benefits? Researchers led by Joseph Arboleda
CONFERENCE COVERAGE 2023-10-21 Conference Coverage Since the 1990s, scientists have known cholesterol is important in Alzheimer's, but they gained little traction in their efforts to understand the relationship between the lipid and the disease. Though amyloid plaques, where the s
CONFERENCE COVERAGE 2023-10-20 Conference Coverage You might well think that myelin, the fatty insulation that speeds action potentials between neurons, falls solely under the purview of oligodendrocytes. After all, these specialized cells wrap cholesterol-laden myelin around axons in
CONFERENCE COVERAGE 2023-10-20 Conference Coverage Readers, ignore lipids at your peril. These oily molecules make up 60 percent of the human brain. Long considered mere wrapping for more interesting cellular contents, these fats hold secrets worth exploring. At the 2nd Symposium on Li
COMMUNITY NEWS 2023-10-19 Community News Clinical care for Alzheimer’s disease is undergoing a sea change. The latest wave? Eleven years after the first amyloid PET tracer was approved by the U.S. Food and Drug Administration, the scans will be broadly covered for Medicare benefic
RESEARCH NEWS 2023-10-18 Research News Fibrillar tau accumulates in several neurodegenerative diseases. Are the same molecular mechanisms responsible, or does each tauopathy follow distinct pathways? Some of both, according to a preprint posted to bioRxiv on September 30. Researc
RESEARCH NEWS 2023-10-14 Research News Neurofibrillary tangles, the hallmark of tauopathies, are closely linked to failing cognition. So are tau oligomers, suggest scientists led by Teresa Gómez-Isla at Massachusetts General Hospital in Boston. In the October 9 JAMA Neurology, th
RESEARCH NEWS 2023-10-13 Research News GWAS uncover associations between genetic variants and human disease, but they do not reveal how those variants act on the body. Linking genetic polymorphisms to changes in plasma proteins could provide some clues. Three papers in the Octobe
RESEARCH NEWS 2023-10-12 Research News Understanding the human brain has entered a new era with the birth of a comprehensive cell atlas. Scientists used single-cell RNA sequencing, epigenetic analyses, and spatial mapping to study millions of brain cells from 100 brain regions, d
RESEARCH NEWS 2023-10-07 Research News Why do some people descend into dementia as they age, while others remain sharp? How do genetic variants influence AD pathogenesis? Ditto for the myriad ephemeral states of microglia influence? These are burning questions in AD research thes
RESEARCH NEWS 2023-10-07 Research News Scientists believe that in late-onset Alzheimer’s disease, Aβ clearance slows, causing the protein to accumulate in plaques. In the September 22 Nature Communications, researchers led by Michael Glickman and Yaron Fuchs at the Technion Israe
