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Long COVID and Dementia: The Link Is Still Elusive

CONFERENCE COVERAGE 2023-05-05 Conference Coverage With the emergence of COVID-19 three years in the past, the lingering neurological effects after initial illness remain nebulous. At the recent International Conference on Alzheimer’s and Parkinson’s Diseases in Gothenburg, Sweden, sci

In Tired Mice, TREM2 Addles Microglia

RESEARCH NEWS 2023-05-05 Research News As anyone who’s tossed and turned through sleepless nights will know, chronic sleep deprivation can turn the simplest task into a challenge. Microglia, it turns out, suffer similarly from no shuteye. According to a study published April 26 i

And Then There Were Three: Donanemab Phase 3 Trial Positive

RESEARCH NEWS 2023-05-04 Research News Score another one for amyloid immunotherapy. The anti-pyroglutamated amyloid antibody donanemab has posted positive top-line results in the Phase 3 Trailblazer-Alz2 study, according to an Eli Lilly press release. The treatment slowed decline

New Arrows Aimed at Tau: Single-Domain Antibody, Peptibody, Vaccine

CONFERENCE COVERAGE 2023-05-03 Conference Coverage Tau pathology is proving a tough nut to crack, with most antibodies directed against it posting negative results in clinical trials thus far. At the recent International Conference on Alzheimer’s and Parkinson’s Diseases in Gothenburg,

Dysregulated Lipid Metabolism Comes to the Fore at AD/PD

CONFERENCE COVERAGE 2023-04-27 Conference Coverage After years of languishing in obscurity, the topic of disruptions in the brain's lipid metabolism is moving center stage. The number of publications in this area is growing, and at the International Conference on Alzheimer’s and P

Paper Alert: Tau Antisense Oligonucleotide BIIB080 Hits Its Target

RESEARCH NEWS 2023-04-26 Research News One strategy for targeting tau pathology—suppressing expression with an antisense oligonucleotide—has recently made strides. At AD/PD 2023, Biogen and partner Ionis Pharmaceuticals had reported that their tau antisense oligonucleotide BIIB08

By Unleashing Microglial cGAS, Tau STINGs Neurons

CONFERENCE COVERAGE 2023-04-26 Conference Coverage Springing a leak is rarely good news, but when microglial mitochondria start oozing, it can be particularly bad in situations of tauopathy. So conclude scientists led by Li Gan and Sadaf Amin, Weill Cornell Medicine, New York, in the A

FDA Grants Accelerated Approval for Tofersen

COMMUNITY NEWS 2023-04-26 Community News The U.S. Food and Drug Administration has approved tofersen for the treatment of ALS. Developed originally by Ionis Pharmaceuticals and evaluated in clinical trials by Biogen, the antisense oligonucleotide (ASO) targets expression of supero

With Microglia, It Takes a Village to Connect the Dots

CONFERENCE COVERAGE 2023-04-25 Conference Coverage New data presented at the International Conference on Alzheimer’s and Parkinson’s Diseases, held March 28 to April 1 in Gothenburg, Sweden, further reinforced the field's growing recognition that microglia respond in myriad ways t

From Phagocytosis to Exophagy: Microglia's Digestive Tract Dissected

CONFERENCE COVERAGE 2023-04-25 Conference Coverage The scientific diet at this year’s International Conference on Alzheimer’s and Parkinson’s diseases, March 28 to April 1 in Gothenburg, was especially rich in news about the ins and outs of the microglial “gastrointestinal tract,” aka

Next Goals for Immunotherapy: Make It Safer, Less of a Hassle

CONFERENCE COVERAGE 2023-04-21 Conference Coverage Anti-amyloid immunotherapy has reached a milestone with the approval of two antibodies for clinical use; alas, the race is far from over. At the International Conference on Alzheimer’s and Parkinson’s Diseases, held March 28 to April 1

Synuclein Assay Passes the Sniff Test—What of Other Seeds?

CONFERENCE COVERAGE 2023-04-21 Conference Coverage Seed amplification assays, those PCR-like reactions for toxic misfolded proteins, are starting to look pretty good. In the May Lancet Neurology, scientists led by Andrew Siderowf, University of Pennsylvania, Philadelphia, and Luis Conc

TREM2 Protects the Brain From Herpes. The Virus Fights Back.

CONFERENCE COVERAGE 2023-04-20 Conference Coverage Retroviruses lurking in the human genome aren’t the only potential troublemakers in neurodegenerative diseases (see Part 5  of this series). Herpes simplex virus type 1 (HSV-1) integrates into the genome of trigeminal ganglia nerves, c

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