6123 RESULTS
RESEARCH NEWS 2024-02-23 Research News The pathological accumulation of TDP-43 that underlies many cases of FTD, ALS, and LATE-NC has been notoriously difficult to recapitulate in mice or cultured human cells. In a paper published February 14 in Nature, scientists led by Magdalin
RESEARCH NEWS 2024-02-21 Research News Type 2 diabetes (T2D) raises a person’s risk of developing dementia by about 50 percent. Does tightly controlling blood sugar decrease that risk? Yes, according to researchers led by Eng-Kiong Yeoh and Kailu Wang at the Chinese University of
RESEARCH NEWS 2024-02-18 Research News Recent proteomic studies have offered glimpses into the biology of early Alzheimer’s disease. Two new preprints take this approach further, describing high-throughput surveys that turned up numerous new candidate biomarkers. In one, posted t
RESEARCH NEWS 2024-02-16 Research News Immune cells in the blood may be intimately involved with Alzheimer’s pathogenesis in the brain. At least, according to their chromatin. A study published January 31 in Neuron reported that in people with AD, the circulating cells—especially
COMMUNITY NEWS 2024-02-16 Community News On January 24, the U.K.’s National Institute for Health and Care Research (NIHR) announced £49.9 million in funding to expand its Dementia Translational Research Collaboration (D-TRC) by creating a trials network led by Catherine Mummery of
RESEARCH NEWS 2024-02-16 Research News Five years ago, scientists described a deletion of six amino acids within the APP gene, reporting that three members of a Swedish family, who each carried one copy of this “ Uppsala deletion,” developed Alzheimer’s disease in their early 40s
RESEARCH NEWS 2024-02-09 Research News Cerebrospinal fluid washes waste from the brain, eventually draining into the lymph nodes and bloodstream—but exactly how this flow bypasses the brain’s barriers to reach the periphery has remained somewhat mysterious. In the February 7 Natu
RESEARCH NEWS 2024-02-09 Research News Just as fluid biomarkers for amyloidosis and tau have revolutionized clinical studies of Alzheimer’s disease, α-synuclein markers are poised to do the same for Parkinson’s. With the advent of sensitive assays that reflect α-synuclein patholo
RESEARCH NEWS 2024-02-08 Research News Progressive supranuclear palsy, a rare tauopathy, slowly destroys a person's cognition, balance, and movement. PSP ranks second behind Parkinson’s disease as a cause of Parkinsonism. Beyond variants in the tau gene, a handful of other r
COMMUNITY NEWS 2024-02-06 Community News As more people in the U.S. seek treatment with the anti-amyloid antibody Leqembi, dementia clinics are becoming swamped, and wait times are lengthening (Jan 2024 news). Many clinicians believe that at least some aspects of diagnosis and tre
COMMUNITY NEWS 2024-02-01 Community News Biogen has thrown in the towel on its controversial anti-amyloid antibody aducanumab. The company announced January 31 that it would stop all development of the drug, and halt the post-market, confirmatory Envision trial. Biogen said it mad
RESEARCH NEWS 2024-02-01 Research News Twelve years ago, clinicians gathered in Vancouver, Canada, for the first international working group meeting on posterior cortical atrophy. At the time, PCA was obscure. It lacked consensus on clinical diagnostic criteria, biomarkers, and e
RESEARCH NEWS 2024-02-01 Research News The structure of ApoE has proven tricky to discern in its native state, namely, attached to lipoproteins. Now, scientists led by David Holtzman at Washington University in St. Louis have captured lipidated ApoE at its highest resolution yet.
RESEARCH NEWS 2024-01-31 Research News Research over the last decade has shown that aggregated Aβ seeds can be transferred between people during rare medical procedures, sparking amyloidosis in the recipient. Could this result in full-blown Alzheimer’s disease? In the January 29
RESEARCH NEWS 2024-01-30 Research News Variants in the TMEM106b gene influence the risk and severity of frontotemporal dementia, but how? A study published January 17 in Science Translational Medicine suggests that the answer comes down to the lysosomal protein’s propensity to tw
