RESEARCH NEWS 2023-06-21 Research News How the brain’s intricate vasculature deteriorates during Alzheimer’s disease has only recently come into focus, thanks to advances in isolating and studying cerebrovascular cells. In a single-nucleus RNA sequencing analysis published in the
RESEARCH NEWS 2023-06-16 Research News Should older adults add taurine to their diets? Perhaps, suggest researchers led by Vijay Yadav, Columbia University, New York. In the June 9 Science, they reported that a person’s ability to make this amino acid declines steeply with age. S
RESEARCH NEWS 2023-06-15 Research News Some researchers have found that, compared to healthy older adults, people who have Alzheimer’s disease harbor unique flora in their guts. So too, do people with preclinical AD, say researchers led by Gautam Dantas and Beau Ances at Washingt
RESEARCH NEWS 2023-06-09 Research News The retromer complex controls protein sorting, transport, and disposal via the endolysosome system. It goes awry in neurodegenerative diseases, but how so remains unclear. Metabolism breaks down in cells lacking retromer, according to a mult
RESEARCH NEWS 2023-06-09 Research News As amyloid plaques accumulate in the brain, excitotoxic synaptic activity revs up in the hippocampus. In the June Nature Neuroscience, researchers led by Bart De Strooper and Joris de Wit at KU Leuven, Belgium, identified melanin-concentrati
RESEARCH NEWS 2023-06-08 Research News Some people become depressed after COVID-19. The cause remains a mystery, but now a small PET study hints that glia might be involved. In the May 31 JAMA Psychiatry, scientists led by Jeffrey Meyer at the University of Toronto reported high
RESEARCH NEWS 2023-06-03 Research News Heart health is brain health. We take this adage for granted, and now a massive new study published in Science on June 2 backs it up. Using deep machine learning to decipher and compare heart and brain MRI scans of more than 40,000 people, r
RESEARCH NEWS 2023-06-02 Research News Why do some people with amyloid plaques decline, while others do not? In the May 29 Nature Medicine, researchers led by Tharick Pascoal at the University of Pittsburgh laid some of the blame on reactive astrocytes. Among cognitively healthy
RESEARCH NEWS 2023-05-27 Research News When deprived of their ability to dispose of detritus via autophagy, microglia become annoyed, transitioning into a senescent, dysfunctional state. That was the upshot of a study published May 25 in Nature Cell Biology. Zhenyu Yue at the Ica
RESEARCH NEWS 2023-05-26 Research News Feel like catching up on the field over Memorial Day weekend? Here's some reading for you. Covering animal models to clinical trials, nine articles in the May issue of Nature Aging discuss current challenges and opportunities in dementi
RESEARCH NEWS 2023-05-26 Research News In mice, data suggest that tau seeds sneak across synapses, spreading tangle pathology throughout the brain. Is the same true in people? Quite likely, say scientists led by Tara Spires-Jones, University of Edinburgh, U.K., and Alberto Lleó,