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FDA Clears Roche’s CSF Aβ42/tTau Assay

RESEARCH NEWS 2023-06-29 Research News Roche announced June 27 that the U.S. FDA has issued 510(k) clearance for the company's CSF Aβ42/total-tau assay to be used for the diagnosis of Alzheimer’s disease in people aged 55 and older. The electrochemiluminescence-based immunoa

Treatment for Lysosomal Storage Disorder Lowers NfL

RESEARCH NEWS 2023-06-23 Research News A Denali treatment for a rare lysosomal storage disorder, Hunter syndrome, has posted encouraging biomarker results in a small, open-label Phase 1/2 trial. The genetic disorder is caused by mutations in the enzyme iduronate-2-sulfatase, whic

Better Cell Model? Transdifferentiated Neurons Capture AD-Like Changes

RESEARCH NEWS 2023-06-22 Research News The use of iPSC-derived neurons to model human diseases like Alzheimer’s has enabled new advances. Nonetheless, a limitation of these cells is that their reprogramming resets epigenetic marks, erasing signatures of aging. One solution: conve

Transcriptomics Confirm Vascular Changes in Alzheimer’s Brain

RESEARCH NEWS 2023-06-21 Research News How the brain’s intricate vasculature deteriorates during Alzheimer’s disease has only recently come into focus, thanks to advances in isolating and studying cerebrovascular cells. In a single-nucleus RNA sequencing analysis published in the

Does Taurine Deficiency Accelerate Aging in Mice, Monkeys?

RESEARCH NEWS 2023-06-16 Research News Should older adults add taurine to their diets? Perhaps, suggest researchers led by Vijay Yadav, Columbia University, New York. In the June 9 Science, they reported that a person’s ability to make this amino acid declines steeply with age. S

Field Loses Another Prominent Neuropathologist, Donald Price, 87

COMMUNITY NEWS 2023-06-16 Community News The Alzheimer’s community lost another notable member with the May 5 passing of Donald Price of Johns Hopkins University, Baltimore, at the age of 87. Price’s work on the cholinergic system was instrumental in the development of cholinester

Listen to Your Gut. It Might Signal Early Alzheimer’s Disease.

RESEARCH NEWS 2023-06-15 Research News Some researchers have found that, compared to healthy older adults, people who have Alzheimer’s disease harbor unique flora in their guts. So too, do people with preclinical AD, say researchers led by Gautam Dantas and Beau Ances at Washingt

Field Says Farewell to Neuropathologist Yasuo Ihara, 78

COMMUNITY NEWS 2023-06-15 Community News The Alzheimer’s field mourns the loss of Yasuo Ihara of Doshisha University in Kizugawa, Japan, who died June 10 at the age of 78 after a long illness. Ihara did pioneering work characterizing pathologic Aβ and tau in the AD brain, and trai

Shrunken FDA Advisory Committee Is Unanimous: Leqembi Works

COMMUNITY NEWS 2023-06-09 Community News A Food and Drug Administration advisory committee today recommended traditional approval of Eisai’s anti-amyloid antibody lecanemab. On the sole voting question before it, the six-member committee unanimously agreed that lecanemab’s Phase 3

Multiomic Analysis Shows Lysosomes Need Retromer to Stay Healthy

RESEARCH NEWS 2023-06-09 Research News The retromer complex controls protein sorting, transport, and disposal via the endolysosome system. It goes awry in neurodegenerative diseases, but how so remains unclear. Metabolism breaks down in cells lacking retromer, according to a mult

A Failing Sleep Neuropeptide Hypes Up Hippocampus

RESEARCH NEWS 2023-06-09 Research News As amyloid plaques accumulate in the brain, excitotoxic synaptic activity revs up in the hippocampus. In the June Nature Neuroscience, researchers led by Bart De Strooper and Joris de Wit at KU Leuven, Belgium, identified melanin-concentrati

Do Activated Glia Contribute to Long COVID?

RESEARCH NEWS 2023-06-08 Research News Some people become depressed after COVID-19. The cause remains a mystery, but now a small PET study hints that glia might be involved. In the May 31 JAMA Psychiatry, scientists led by Jeffrey Meyer at the University of Toronto reported high

Multi-Organ MRI Unveils Myriad Connections Between Heart and Brain

RESEARCH NEWS 2023-06-03 Research News Heart health is brain health. We take this adage for granted, and now a massive new study published in Science on June 2 backs it up. Using deep machine learning to decipher and compare heart and brain MRI scans of more than 40,000 people, r

CMS Sticks to Its Guns on Amyloid Immunotherapy Coverage

COMMUNITY NEWS 2023-06-02 Community News With Food and Drug Administration approval decisions for the amyloid antibodies lecanemab  and donanemab expected this year, the Centers for Medicare and Medicaid Services have clarified how they plan to cover these drugs. In a June 1 state

In Amyloid Cascade, Do Reactive Astrocytes Bridge Plaques and Tangles?

RESEARCH NEWS 2023-06-02 Research News Why do some people with amyloid plaques decline, while others do not? In the May 29 Nature Medicine, researchers led by Tharick Pascoal at the University of Pittsburgh laid some of the blame on reactive astrocytes. Among cognitively healthy

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