RESEARCH NEWS 2023-06-29 Research News Roche announced June 27 that the U.S. FDA has issued 510(k) clearance for the company's CSF Aβ42/total-tau assay to be used for the diagnosis of Alzheimer’s disease in people aged 55 and older. The electrochemiluminescence-based immunoa
RESEARCH NEWS 2023-06-23 Research News A Denali treatment for a rare lysosomal storage disorder, Hunter syndrome, has posted encouraging biomarker results in a small, open-label Phase 1/2 trial. The genetic disorder is caused by mutations in the enzyme iduronate-2-sulfatase, whic
RESEARCH NEWS 2023-06-22 Research News The use of iPSC-derived neurons to model human diseases like Alzheimer’s has enabled new advances. Nonetheless, a limitation of these cells is that their reprogramming resets epigenetic marks, erasing signatures of aging. One solution: conve
RESEARCH NEWS 2023-06-21 Research News How the brain’s intricate vasculature deteriorates during Alzheimer’s disease has only recently come into focus, thanks to advances in isolating and studying cerebrovascular cells. In a single-nucleus RNA sequencing analysis published in the
RESEARCH NEWS 2023-06-16 Research News Should older adults add taurine to their diets? Perhaps, suggest researchers led by Vijay Yadav, Columbia University, New York. In the June 9 Science, they reported that a person’s ability to make this amino acid declines steeply with age. S
RESEARCH NEWS 2023-06-15 Research News Some researchers have found that, compared to healthy older adults, people who have Alzheimer’s disease harbor unique flora in their guts. So too, do people with preclinical AD, say researchers led by Gautam Dantas and Beau Ances at Washingt
RESEARCH NEWS 2023-06-09 Research News The retromer complex controls protein sorting, transport, and disposal via the endolysosome system. It goes awry in neurodegenerative diseases, but how so remains unclear. Metabolism breaks down in cells lacking retromer, according to a mult
RESEARCH NEWS 2023-06-09 Research News As amyloid plaques accumulate in the brain, excitotoxic synaptic activity revs up in the hippocampus. In the June Nature Neuroscience, researchers led by Bart De Strooper and Joris de Wit at KU Leuven, Belgium, identified melanin-concentrati
RESEARCH NEWS 2023-06-08 Research News Some people become depressed after COVID-19. The cause remains a mystery, but now a small PET study hints that glia might be involved. In the May 31 JAMA Psychiatry, scientists led by Jeffrey Meyer at the University of Toronto reported high
RESEARCH NEWS 2023-06-03 Research News Heart health is brain health. We take this adage for granted, and now a massive new study published in Science on June 2 backs it up. Using deep machine learning to decipher and compare heart and brain MRI scans of more than 40,000 people, r
RESEARCH NEWS 2023-06-02 Research News Why do some people with amyloid plaques decline, while others do not? In the May 29 Nature Medicine, researchers led by Tharick Pascoal at the University of Pittsburgh laid some of the blame on reactive astrocytes. Among cognitively healthy