6124 RESULTS
RESEARCH NEWS 2022-10-27 Research News Unlike the simple response of mouse microglia to amyloid plaques, human microglia react in diverse ways that researchers are just beginning to understand. Data from two different model systems, one in vivo and one in vitro, now provide a rem
RESEARCH NEWS 2022-10-26 Research News A top contender among amyloid immunotherapies, donanemab lowered plaque load in the Phase 2 TRAILBLAZER trial. As reported last year at AAIC, this swift amyloid removal was accompanied by a drop in plasma p-tau217. Now, scientists led by Mic
RESEARCH NEWS 2022-10-22 Research News The death of synapses, and the neurons that need them, marks the inevitable endgame of Alzheimer’s disease. Despite this eventual synaptic mayhem, a new work, led by Thomas Südhof and Marius Wernig at Stanford University, supports the idea t
RESEARCH NEWS 2022-10-21 Research News In the October 19 Science Advances, researchers led by Michel Cayouette, McGill University, Montreal, reported that the trafficking protein Numb tempers tau tangles in mouse retinal ganglion cells and in motor neurons. In tauopathy mice, ove
RESEARCH NEWS 2022-10-18 Research News Amyotrophic lateral sclerosis and frontotemporal dementia may seem like different diseases, but they are often marked by the same pathology, namely, cytoplasmic inclusions of TDP-43. Hexanucleotide expansions in the C9ORF72 gene, or, more ra
RESEARCH NEWS 2022-10-14 Research News Could overexpression of certain genes put women at a higher risk of Alzheimer’s disease? This seems to be the case for USP11, which partially evades silencing on one of the X chromosomes. This gene encodes a peptidase that removes ubiquitin
COMMUNITY NEWS 2022-10-14 Community News The Alzheimer’s Disease Neuroimaging Initiative, now 18 years old, was instrumental in transforming researchers’ conceptions of AD by revealing the decades-long, preclinical buildup of amyloid plaques in the brain. This landmark study conti
RESEARCH NEWS 2022-10-13 Research News In the Alzheimer’s field, detailed knowledge of how biomarkers change at preclinical stages has enabled researchers to select the best participants for disease-modifying prevention trials. For frontotemporal dementia, this knowledge has been
RESEARCH NEWS 2022-10-12 Research News Hot on the heels of a report from Denmark that walking 9,800 steps per day in middle age slashed dementia risk in half, researchers led by Evan Brittain, Vanderbilt University Medical Center, Nashville, corroborated those findings for other
RESEARCH NEWS 2022-10-12 Research News As Aβ plaques accumulate in the brain, microglia are increasingly called upon to clean up the mess. This relentless phagocytic feasting requires enormous amounts of energy in the form of adenosine triphosphate, but by boosting glycolysis, th
RESEARCH NEWS 2022-10-09 Research News Peering into the brain to watch cholesterol metabolism in real time may have just become a reality, thanks to a new PET tracer. In the October 5 Science Translational Medicine, researchers led by Steven Liang at Emory University, Atlanta, de
RESEARCH NEWS 2022-10-07 Research News When Eisai and Biogen announced positive top-line results for their anti-amyloid antibody lecanemab, the trial became the first successful, completed Phase 3 Alzheimer's drug study in the Western world in more than 20 years. If lecanema
RESEARCH NEWS 2022-10-06 Research News Can the many metabolites coursing through your blood foretell the diabetes, heart disease, or dementia diagnosis that awaits you sometime down the road? Yes, according to researchers led by Ulf Landmesser and Roland Eils, Berlin Institute of
CONFERENCE COVERAGE 2022-10-05 Conference Coverage Scientists now have a slew of biomarkers, both fluid assays and PET ligands, that distinguish Alzheimer’s from other neurodegenerative diseases, such as frontotemporal dementia, Parkinson’s, and dementia with Lewy bodies (DLB). But in
CONFERENCE COVERAGE 2022-10-04 Conference Coverage Few scientists doubt that backed-up clearance of detritus from the brain correlates with accumulation of amyloid plaques and neurofibrillary tangles. But which comes first? Data presented at the 9th Kuopio Alzheimer Symposium suggests
