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RESEARCH NEWS 2022-11-22 Research News The brain is the softest organ of the body, so when rigid Aβ plaques form, they stand in stark contrast to the squishiness surrounding them. Microglia sense this rigidity via Piezo1, a calcium channel that opens in response to mechanical sti
RESEARCH NEWS 2022-11-19 Research News What triggers the vascular Aβ deposits known as cerebral amyloid angiopathy (CAA)? In the November 16 Nature, researchers led by Jonas Neher at the German Center for Neurodegenerative Diseases in Tübingen, Germany, nominate medin, a small ag
RESEARCH NEWS 2022-11-18 Research News Researchers know that ApoE4 and Trem2 can worsen neurodegeneration in mouse models of tauopathy. Do these proteins conspire to exacerbate pathology? It turns out that ApoE4 causes much of the damage alone, according to scientists led by Davi
RESEARCH NEWS 2022-11-14 Research News Today, Roche and Genentech announced negative top-line results for their anti-amyloid antibody gantenerumab. In the two Phase 3 GRADUATE trials, the drug failed to slow cognitive decline on the CDR-SB. In addition, it removed less amyloid pl
RESEARCH NEWS 2022-11-11 Research News With age, the brain’s ability to clear aggregating proteins such as Aβ wanes. In the November 9 Nature, researchers led by Jonathan Kipnis at Washington University in St. Louis suggest a reason why. They found that the macrophages that cozy
RESEARCH NEWS 2022-11-11 Research News Astrocytes, the so-called helper cells of the brain, permeate the entire central nervous system. How similar are these cells to one another? Not very, according to a new transcriptomic analysis. Researchers led by Baljit Khakh, University of
RESEARCH NEWS 2022-11-10 Research News Some call them soluble oligomers, others prefer the term protofibrils. Regardless, most researchers agree on two things when it comes to free-wheeling aggregates of Aβ: They are more toxic than their plaque-bound counterparts, and their stru
RESEARCH NEWS 2022-11-05 Research News Alzheimer’s researchers have long wished for better mouse models. That is now coming true. Scientists at the Jackson Laboratory in Bar Harbor, Maine, are cranking out numerous lines that express humanized Aβ and tau in combination with late-
RESEARCH NEWS 2022-11-04 Research News In the last decade, induced pluripotent stem cells have opened the floodgates for studying human biology in a dish, or well, as the case may be. However, the genetic heterogeneity of human cells makes it difficult to compare findings among l
RESEARCH NEWS 2022-11-03 Research News Activating the cell surface receptor TREM2 rallies microglia to clear amyloid plaques. Can activating a kinase downstream of TREM2 do the same? Two groups of scientists say yes. In the October 26 Cell, researchers led by Marco Colonna, Washi
RESEARCH NEWS 2022-10-28 Research News In the October 11 Journal of Experimental Medicine, scientists led by David Holtzman, Washington University School of Medicine in St. Louis, reported that a TREM2 agonistic antibody mobilized microglia to surround plaques, yet did not abate
RESEARCH NEWS 2022-10-27 Research News Unlike the simple response of mouse microglia to amyloid plaques, human microglia react in diverse ways that researchers are just beginning to understand. Data from two different model systems, one in vivo and one in vitro, now provide a rem
RESEARCH NEWS 2022-10-26 Research News A top contender among amyloid immunotherapies, donanemab lowered plaque load in the Phase 2 TRAILBLAZER trial. As reported last year at AAIC, this swift amyloid removal was accompanied by a drop in plasma p-tau217. Now, scientists led by Mic
RESEARCH NEWS 2022-10-22 Research News The death of synapses, and the neurons that need them, marks the inevitable endgame of Alzheimer’s disease. Despite this eventual synaptic mayhem, a new work, led by Thomas Südhof and Marius Wernig at Stanford University, supports the idea t
RESEARCH NEWS 2022-10-21 Research News In the October 19 Science Advances, researchers led by Michel Cayouette, McGill University, Montreal, reported that the trafficking protein Numb tempers tau tangles in mouse retinal ganglion cells and in motor neurons. In tauopathy mice, ove
