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RESEARCH NEWS 2023-02-08 Research News Good news for the curious scientist: Spatial transcriptomics got another bump in resolution. In Nature Neuroscience on February 2, researchers led by Morgan Sheng and Xiao Wang of the Broad Institute at Massachusetts Institute of Technology
RESEARCH NEWS 2023-02-03 Research News Could a biomarker for TDP-43 pathology be on the horizon? This RNA/DNA-binding protein accumulates in nearly all people with amyotrophic lateral sclerosis, and almost half of those with frontotemporal dementia, but can only be detected at au
RESEARCH NEWS 2023-02-03 Research News The 12 kilodalton FK506 binding protein (FKBP12) interacts with tau to attenuate aggregation. But how this small protein filled such big shoes was unclear—until now. In the February 1 Science Advances, researchers led by Benjamin Wolozin at
RESEARCH NEWS 2023-02-02 Research News Avoiding a severe bout of flu in middle age may protect a person’s future brain health, according to a large population-based study. In the January 19 Neuron, researchers led by Mike Nalls at the National Institutes of Health, Bethesda, Mary
RESEARCH NEWS 2023-02-01 Research News A new study offers up yet more evidence that the endosome may be ground zero for Alzheimer’s disease pathogenesis. In Proceedings of the National Academy of Sciences on January 18, scientists led by Olav Andersen of Aarhus University in Denm
RESEARCH NEWS 2023-01-27 Research News Phosphorylation of α-synuclein at serine 129 has long been used as a marker of synucleinopathy—p-S129syn accumulates in Lewy bodies, after all. But does this modification have a physiological function? Two recent papers suggest that neuronal
RESEARCH NEWS 2023-01-27 Research News While people who carry one hypofunctional variant in the TREM2 gene have a heightened risk for Alzheimer’s disease, those with two dysfunctional copies of this microglial receptor, or its partner, DAP12, face a more severe fate. They develop
RESEARCH NEWS 2023-01-26 Research News The massive social disruptions caused by the COVID-19 pandemic hit particularly hard for people living with dementia, causing them to become more isolated and less able to take part in normal activities and routines. How did this affect thei
RESEARCH NEWS 2023-01-25 Research News Synaptic changes lie at the nexus of many neurodegenerative diseases, underpinning cognitive decline. However, it has been hard to get a handle on exactly how these tiny structures change in disease, because scientists have had no way to exa
RESEARCH NEWS 2023-01-20 Research News In a move that surprised many, the Food and Drug Administration has rejected Eli Lilly’s application for accelerated approval for its anti-amyloid antibody donanemab. The agency said there was not enough safety data, given that fewer than 10
RESEARCH NEWS 2023-01-20 Research News Ever since linking loss-of-function mutations in the microglial gene TREM2 to a higher risk of Alzheimer’s disease, scientists have been developing antibodies to boost TREM2 signaling. The latest? A human antibody bestowed with enhanced abil
RESEARCH NEWS 2023-01-20 Research News Most Aβ fibril structures described to date have come from the parenchyma or the brain vasculature of people with AD. A new study, posted December 22 on bioRxiv, resolved the structures of fibrils plucked from the cerebrovasculature of two p
RESEARCH NEWS 2023-01-18 Research News How does aggregated tau wreak damage? In the January 6 Science Advances, researchers led by Bess Frost at the University of Texas Health San Antonio make a case for tau unleashing double-stranded RNA. In fruit fly brain, mutant tau opened up
RESEARCH NEWS 2023-01-15 Research News Part 2 of 2 From the all-important treatment perspective, 2022 ended on a high note, with Phase 3 data from lecanemab setting up its FDA approval (see Part 1 of this review). There was plenty of action on the basic research front, too, from
RESEARCH NEWS 2023-01-15 Research News Part 1 of 2 The year 2022 was a turning point in Alzheimer's research. It began with the Aduhelm debacle fresh on people's mind. It ended with reassurance that amyloid removal indeed helps people with the disease, when lecanemab�
