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Not Quite a Dolly, But It's a Human Clone

RESEARCH NEWS 2004-02-12 Research News Updated 21 January 2005: Science magazine has formally retracted this paper because its data were fabricated; see ARF related news story. 12 February 2004. Researchers in South Korea have apparently cloned the first human embryo. Perhaps equ

New Microarray Data Offer Grist for AD Hypothesizing Mills

RESEARCH NEWS 2004-02-08 Research News Check out the newest gene microarray results in the Alzheimer's brain, and see if they give a lift to some of your favorite hypotheses and molecular suspects. The study, by Eric Blalock, Philip Landfield, and colleagues at the Universit

Lost in Translation: Memories Need MAP to Find Their Way Home

RESEARCH NEWS 2004-02-08 Research News The quest to unveil the mystery of memory and synaptic plasticity—for some years the domain of behavioral biologists and electrophysiologists—has led scientists squarely back to basic molecular biology. Because long-lasting memories require

Alternative Splicing May Make Cells Unique

RESEARCH NEWS 2004-02-07 Research News The analogy of a computer has often been used to explain the workings of the brain, and vice versa. In computers, however, each byte has a unique address that allows the processor to track where it stored snippets of information. The brain,

Exchange of Letters Asks if Silver Lining in Vaccine Trial Was Real

RESEARCH NEWS 2004-02-05 Research News One bit of reassuring evidence tempered the dismay over the encephalitis cases that ended dosing in the phase 2 trial of an Aβ vaccine: At least the vaccine removed the plaques. Not so fast, write Haruhiko Akiyama of the Tokyo Institute of P

Newfangled Genome Maps May Guide the Hunt for Disease Genes

RESEARCH NEWS 2004-02-05 Research News Two papers in tomorrow's Science describe genetic maps that may prove useful for studying the genetic basis for human disease. A team of Canadian scientists led by Charles Boone at the University of Toronto report that they have constru

Agonist of PPARγ Cousin PPARδ Flags Cancer Caution

RESEARCH NEWS 2004-02-04 Research News Activators of peroxisome proliferator-activated receptor-γ (PPARγ), which sensitize tissues to insulin, are widely used to treat type II diabetes. The realization that these drugs also reduce inflammation (see recent Live Discussion on PPARγ

Could Alzheimer’s Drugs Mean “Good Night” to Good Memory?

RESEARCH NEWS 2004-01-30 Research News If you want to make sure to remember something, sleep on it. Sleep research confirms this adage, and indeed, its chemical underpinnings may have surprising implications for Alzheimer’s disease treatment. Neurons communicate with one another

Mild Fragile X Mutations Cause Parkinson's Symptoms in Elderly

RESEARCH NEWS 2004-01-30 Research News Elderly men with symptoms of ataxia and intention tremor may actually have a disorder related to fragile X syndrome, a common form of mental retardation in children. These men show signs of Parkinson's disease or dementia and are someti

GSK3β—Not Just for Tauists Anymore

RESEARCH NEWS 2004-01-30 Research News Alzheimer's researchers sneak regular peeks over the shoulders of colleagues working on Parkinson's and other neurodegenerative diseases. Why not do the same with schizophrenia researchers, who are working in a disease that feature

Cellular Prions Fingered Once Again

RESEARCH NEWS 2004-01-30 Research News Which is more dangerous, the cellular (PrPc) or the infectious (PrPSc) prion protein? Until recently, this would have been easy to answer. But evidence is growing that the cellular variant may be just as toxic as the infectious one. In today

Atomic Force Microscope Shows Antibodies Can Prevent Fibrils

RESEARCH NEWS 2004-01-26 Research News A nifty instrument for mapping the 3-D shape of macromolecular surfaces, the atomic force microscope (AFM) over the last five years has become an established method of measuring how environmental conditions affect Aβ fibril formation as well

Lipoproteins and Amyloid-β—A Fat Connection

RESEARCH NEWS 2004-01-23 Research News Cholesterol and lipoproteins, particularly ApoE, are two known risk factors for idiopathic Alzheimer’s disease. But despite numerous reports, scientists’ understanding of how they influence the disease process remains vague, in part because

Erene Mina Reports on Presenilin’s Loops through the Membrane

RESEARCH NEWS 2004-01-23 Research News Going against the grain is never easy, and in science, especially, if you are proposing a rival model, you had better have strong evidence to support it. A paper appearing in this week’s early online PNAS rekindles the debate concerning the

Trial of Memantine/Donepezil Paves the Way for Combination Therapy

RESEARCH NEWS 2004-01-22 Research News Combining memantine with an older, widely used AD drug further improves measures of cognition, global well-being, activities of daily living, and behavior in people with moderate to severe AD, according to a study published in the January 21

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