6120 RESULTS
RESEARCH NEWS 2003-11-03 Research News A paper in last Friday's Science reports that autosomal-dominant Parkinson's disease can be caused not only by α-synuclein mutations, but also by a triplication of a fragment of DNA containing the gene. This result suggests that do
CONFERENCE COVERAGE 2003-11-03 Conference Coverage The meeting of the Memory Disorders Research Society in Chicago, held 9-11 October, opened with a session on two neurodegenerative syndromes: primary progressive aphasia (PPA) and semantic dementia (SD). Each of these syndromes bears s
INTERVIEWS 2003-10-31 Interviews Dennis Selkoe Interview with Dennis Selkoe. The Alzheimer Research Forum posted an interview with Dennis Selkoe of Brigham and Women's Hospital in Boston in 1999. Since then, many new findings have come to light. How has the field shifted?
RESEARCH NEWS 2003-10-31 Research News British researchers report in today’s Science that they have managed to prevent and even reverse clinical manifestations of prion disease. Surprisingly, they did it not by eliminating deposits of abnormal prions, but by depleting normal prio
RESEARCH NEWS 2003-10-24 Research News In today's Science, Cynthia Kenyon and colleagues at the University of California, San Francisco, report that they have generated transgenic nematodes, Caenorhabditis elegans, that live six times longer than normal, the equivalent of ab
RESEARCH NEWS 2003-10-24 Research News In the complex milieu of the cell membrane, some lipids often go against the flow and separate from the main pack to form their own small patch. Such lipid rafts, as they are known, are often packed with cholesterol and have been associated
CONFERENCE COVERAGE 2003-10-24 Conference Coverage Jeff Rothstein of Johns Hopkins University last Monday chaired a symposium on animal models of neurologic diseases at the American Neurological Association, held in San Francisco from October 19 to 22. Two talks were particularly relev
RESEARCH NEWS 2003-10-21 Research News The FDA last Friday followed the recommendation of its advisory panel last month (see ARF related news story) and approved memantine for use in moderate to severe AD. Forest Laboratories will sell the drug under the brand name Namenda. Thoug
RESEARCH NEWS 2003-10-17 Research News The chemokine receptor CCR1 might be an early and specific marker of Alzheimer's disease, researchers suggest in the November issue of Annals of Neurology, now available online. Meredith Halks-Miller and colleagues at Berlex Biosciences
RESEARCH NEWS 2003-10-17 Research News In this week's advanced online edition of PNAS, Raphael Kopan from Washington University School of Medicine, St. Louis, and a host of international collaborators, report that presenilin (PS), the aspartyl protease proposed to be the hea
INTERVIEWS 2003-10-16 Interviews Akihiko Takashima Interview with Akihiko Takashima, RIKEN Brain Science Institute, Wako, Saitama, Japan. Q&A ARF: What's your current thinking on the relationship between Ab and tau? AT: Our current working hypothesis is that the norma
RESEARCH NEWS 2003-10-16 Research News Immune molecules, thought to act exclusively in the periphery presenting antigens and fighting infection, in fact, have an alter ego in the brain's neurons, where they help remodel synapses in response to neural activity. How's thi
RESEARCH NEWS 2003-10-16 Research News A classic case of scientific serendipity has added an ironic wrinkle to the prion story. An article in today's Nature shows intriguing evidence that prions may indeed need nucleic acids to infect hosts-yet these nucleic acids may come f
RESEARCH NEWS 2003-10-14 Research News Shedding light on why mutations in parkin protein might cause familial Parkinson's disease, a study in the October 6 online PNAS shows how overexpression of one of parkin's targets can cause degeneration of dopamine neurons in vivo
RESEARCH NEWS 2003-10-14 Research News If humans genetically are almost identical to their primate relatives, what is it that makes us smarter? This question has befuddled scientists for some time. In this week’s PNAS early online edition, researchers at the Salk Institute for Bi
