6124 RESULTS
RESEARCH NEWS 2003-12-03 Research News Is the cycle of life—new lives born even as the old die—to be found in the hippocampus of Alzheimer's patients? A study in this week’s online PNAS suggests just this, and poses the question of whether we could spur newly born neurons to
CONFERENCE COVERAGE 2003-12-03 Conference Coverage By Erene Mina. As evidence mounts against oligomers as culprits of Aβ neurotoxicity (see ARF related New Orleans story), their only defense hinges on the possibility that they may have some normal physiological function—even a slightly
CONFERENCE COVERAGE 2003-12-03 Conference Coverage Notwithstanding some redeeming features (ARF related New Orleans story) soluble Aβ oligomers have an overwhelmingly bad reputation as suspected mediators of synaptic dysfunction in Alzheimer’s. A number of accusing fingers have pointed
CONFERENCE COVERAGE 2003-11-26 Conference Coverage Many academic scientists find news about industry research hard to find. It travels by word of mouth, formal publications appear late, if ever. This is true of γ-secretase inhibitors, which for a while were prime candidates for the nex
RESEARCH NEWS 2003-11-26 Research News The potential of RNA interference is exciting, offering the possibility of shutting down expression of specific proteins—perhaps in specific cells—for both investigative and therapeutic purposes (see ARF live discussion on this subject). But
RESEARCH NEWS 2003-11-26 Research News Antibodies have proven to be extremely versatile tools for detecting proteins both in vitro and in vivo, but they need to be coupled to an additional label, such as an enzyme, radioisotope, or fluorophore. Now enter the "fluorobody,&quo
CONFERENCE COVERAGE 2003-11-25 Conference Coverage Are you sometimes tempted to view APP and presenilin merely as raw material and machine for Aβ production, respectively? If so, think again, because that narrow spotlight is opening up to a broader understanding of how these two protei
CONFERENCE COVERAGE 2003-11-21 Conference Coverage At the 33rd Annual Meeting of the Society for Neuroscience held last week in New Orleans, at least two dozen presentations dealt with current efforts to develop a vaccine for Alzheimer’s disease. This bold approach suffered a setback l
CONFERENCE COVERAGE 2003-11-21 Conference Coverage The role of inflammation in Alzheimer’s disease—beyond serious dispute, yet still enigmatic—gained much attention at the 33rd Annual Meeting of the Society for Neuroscience, held last week in New Orleans. While immunotherapy labs are r
RESEARCH NEWS 2003-11-21 Research News Dopaminergic, serotonergic, and glutamatergic: three CNS neurotransmitter pathways that are distinct. Or are they? A paper in this week's Science reveals that all three pathways eventually lead to one protein, the dopamine- and cAMP-reg
RESEARCH NEWS 2003-11-19 Research News In this month's Aging Cell, researchers show that the herpes simplex virus (HSV), traveling away from the neuronal cell body along axons, is associated with the amyloid precursor protein (APP). This finding offers some new insights into
RESEARCH NEWS 2003-11-14 Research News After years as a potential but peripheral suspect in the pathogenesis of Alzheimer's disease, copper (Cu) is lobbying for a new designation—potential therapy! Two studies in the November 17 PNAS Early Edition suggest that copper can inc
RESEARCH NEWS 2003-11-13 Research News Some people are genetically predisposed to specific autoimmune diseases such as rheumatoid arthritis, though for the most part, the reason for their susceptibility is unclear. Now, in this month's Nature Genetics, two papers reveal that
RESEARCH NEWS 2003-11-10 Research News More than 50 years ago, U.S. Navy physicians stationed on Guam found a shocking rate of amyotrophic lateral sclerosis, or ALS—about 50 to 100 times higher than expected. Now, a new paper in the Nov. 11 Proceedings of the National Academy of
RESEARCH NEWS 2003-11-10 Research News The table of evidence regarding inflammatory and even autoimmune processes in Alzheimer's continues to accumulate in a piecemeal fashion, awaiting theoretical frameworks and experimental breakthroughs to give it direction and a greater
