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ATM Links DNA Damage to Neuronal Cell Cycle Activation and Apoptosis

RESEARCH NEWS 2004-02-19 Research News Finding a working ATM when you’re short of cash can be a life-saver. If you are a neuron, however, you may want to keep your ATM out of order because the currency it dishes out can be lethal. In today’s Neuron, researchers report that ATM, o

A Growing Portfolio: CDK5 Implicated in Parkinson’s, Too

RESEARCH NEWS 2004-02-15 Research News The sliver of brain called striatum plays a key role in integrating dopaminergic inputs from the midbrain and glutamatergic inputs from the thalamus and neocortex, a job that enables a person to process motor- and reward-related behaviors pr

Nitric Oxide and Zinc—Conspirators in Cell Death

RESEARCH NEWS 2004-02-12 Research News Individually, both nitric oxide (NO) and zinc (Zn+) have been implicated in triggering neurodegeneration (see related news for NO) and Zn2+). But who would have thought that the two small molecules act in concert to activate apoptosis? That&

Not Quite a Dolly, But It's a Human Clone

RESEARCH NEWS 2004-02-12 Research News Updated 21 January 2005: Science magazine has formally retracted this paper because its data were fabricated; see ARF related news story. 12 February 2004. Researchers in South Korea have apparently cloned the first human embryo. Perhaps equ

New Microarray Data Offer Grist for AD Hypothesizing Mills

RESEARCH NEWS 2004-02-08 Research News Check out the newest gene microarray results in the Alzheimer's brain, and see if they give a lift to some of your favorite hypotheses and molecular suspects. The study, by Eric Blalock, Philip Landfield, and colleagues at the Universit

Lost in Translation: Memories Need MAP to Find Their Way Home

RESEARCH NEWS 2004-02-08 Research News The quest to unveil the mystery of memory and synaptic plasticity—for some years the domain of behavioral biologists and electrophysiologists—has led scientists squarely back to basic molecular biology. Because long-lasting memories require

Alternative Splicing May Make Cells Unique

RESEARCH NEWS 2004-02-07 Research News The analogy of a computer has often been used to explain the workings of the brain, and vice versa. In computers, however, each byte has a unique address that allows the processor to track where it stored snippets of information. The brain,

Exchange of Letters Asks if Silver Lining in Vaccine Trial Was Real

RESEARCH NEWS 2004-02-05 Research News One bit of reassuring evidence tempered the dismay over the encephalitis cases that ended dosing in the phase 2 trial of an Aβ vaccine: At least the vaccine removed the plaques. Not so fast, write Haruhiko Akiyama of the Tokyo Institute of P

Newfangled Genome Maps May Guide the Hunt for Disease Genes

RESEARCH NEWS 2004-02-05 Research News Two papers in tomorrow's Science describe genetic maps that may prove useful for studying the genetic basis for human disease. A team of Canadian scientists led by Charles Boone at the University of Toronto report that they have constru

Agonist of PPARγ Cousin PPARδ Flags Cancer Caution

RESEARCH NEWS 2004-02-04 Research News Activators of peroxisome proliferator-activated receptor-γ (PPARγ), which sensitize tissues to insulin, are widely used to treat type II diabetes. The realization that these drugs also reduce inflammation (see recent Live Discussion on PPARγ

Could Alzheimer’s Drugs Mean “Good Night” to Good Memory?

RESEARCH NEWS 2004-01-30 Research News If you want to make sure to remember something, sleep on it. Sleep research confirms this adage, and indeed, its chemical underpinnings may have surprising implications for Alzheimer’s disease treatment. Neurons communicate with one another

Mild Fragile X Mutations Cause Parkinson's Symptoms in Elderly

RESEARCH NEWS 2004-01-30 Research News Elderly men with symptoms of ataxia and intention tremor may actually have a disorder related to fragile X syndrome, a common form of mental retardation in children. These men show signs of Parkinson's disease or dementia and are someti

GSK3β—Not Just for Tauists Anymore

RESEARCH NEWS 2004-01-30 Research News Alzheimer's researchers sneak regular peeks over the shoulders of colleagues working on Parkinson's and other neurodegenerative diseases. Why not do the same with schizophrenia researchers, who are working in a disease that feature

Cellular Prions Fingered Once Again

RESEARCH NEWS 2004-01-30 Research News Which is more dangerous, the cellular (PrPc) or the infectious (PrPSc) prion protein? Until recently, this would have been easy to answer. But evidence is growing that the cellular variant may be just as toxic as the infectious one. In today

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