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Adieu to Aduhelm: Biogen Stops Marketing Antibody

COMMUNITY NEWS 2024-02-01 Community News Biogen has thrown in the towel on its controversial anti-amyloid antibody aducanumab. The company announced January 31 that it would stop all development of the drug, and halt the post-market, confirmatory Envision trial. Biogen said it mad

Posterior Cortical Atrophy Is a Form of Young-Onset Alzheimer’s

RESEARCH NEWS 2024-02-01 Research News Twelve years ago, clinicians gathered in Vancouver, Canada, for the first international working group meeting on posterior cortical atrophy. At the time, PCA was obscure. It lacked consensus on clinical diagnostic criteria, biomarkers, and e

In Lipoparticles, ApoE Double Belt Keeps the Fat In

RESEARCH NEWS 2024-02-01 Research News The structure of ApoE has proven tricky to discern in its native state, namely, attached to lipoproteins. Now, scientists led by David Holtzman at Washington University in St. Louis have captured lipidated ApoE at its highest resolution yet.

First Evidence for Transmitted Alzheimer’s Disease?

RESEARCH NEWS 2024-01-31 Research News Research over the last decade has shown that aggregated Aβ seeds can be transferred between people during rare medical procedures, sparking amyloidosis in the recipient. Could this result in full-blown Alzheimer’s disease? In the January 29

In FTD, TMEM106b Fibrils Tip TDP-43 Dysfunction into Overdrive

RESEARCH NEWS 2024-01-30 Research News Variants in the TMEM106b gene influence the risk and severity of frontotemporal dementia, but how? A study published January 17 in Science Translational Medicine suggests that the answer comes down to the lysosomal protein’s propensity to tw

Brain of Woman Who Died on Leqembi Shows Worst-Case Scenario

RESEARCH NEWS 2024-01-26 Research News Part 2 of 2. Click here for Part 1. What happens in the brain of a person with fatal ARIA? Researchers now have one of their first detailed looks at the pathology of this rare and calamitous condition. In the December 12 Nature Communication

Rising Leqembi Prescriptions Are Straining Clinic Capacity

RESEARCH NEWS 2024-01-26 Research News Part 1 of 2. Click here for Part 2. As Alzheimer’s clinicians across the U.S. started offering a disease-modifying treatment to their patients, uptake at first was slow but is now speeding up. Six months after Eisai’s anti-amyloid antibody l

AD Blood Tests Are Here. Now, Let's Grapple With How to Use Them

RESEARCH NEWS 2024-01-25 Research News Not so long ago, a blood test for Alzheimer’s disease seemed a pipe dream. Now, after years of study, the field is awash with sensitive assays that signal the proteopathic culprits Aβ and tau coalescing in the brain. As these blood tests vie

Paper Alert: p-Tau217 Blood Test Predicts Plaques, Tangles Over Time

RESEARCH NEWS 2024-01-24 Research News Researchers led by Nicholas Ashton at the University of Gothenburg, Sweden, recently reported that ALZpath Inc.’s plasma phospho-tau217 assay detected amyloid and tau positivity with 92 to 97 percent accuracy. Now, the data is peer-reviewed

Cholesterol Metabolite Ups Estrogen Signaling to Keep Females Sharp

RESEARCH NEWS 2024-01-24 Research News Cholesterol clears the brain once metabolized to 24-hydroxycholesterol, but that is not the only way 24HC can be beneficial, according to Silvia Maioli at the Karolinska Institutet in Stockholm. In the January 24 Science Advances, Maioli and

FDA Approves BrainSee, AI Software That Purportedly Predicts AD

RESEARCH NEWS 2024-01-19 Research News When people come to their doctor with memory problems, they tend to want to know if Alzheimer's is to blame and, if so, what they can expect. Answering these questions with a degree of certainty is a tall order, and many view amyloid-PE

Mouse Model LOADs on the Risk Factors

RESEARCH NEWS 2024-01-19 Research News The search for a good model of late-onset Alzheimer’s disease continues. Researchers led by Adrian Oblak of the Indiana University School of Medicine in Indianapolis and Gareth Howell at the Jackson Laboratory (JAX), Bar Harbor, Maine, have

Per Simoa, CSF p-tau205 Tracks with Tangles, Disease Progression

RESEARCH NEWS 2024-01-17 Research News Most phospho-tau fluid biomarkers validated so far track more tightly with amyloid plaques than they do with tau tangles. A new study published January 6 in Acta Neuropathologica confirms that p-tau205 breaks that mold. In the cerebrospinal

Mind the GAP—Synaptic Protein in CSF Signals Tau Spread

RESEARCH NEWS 2024-01-17 Research News Some scientists believe that toxic tau fibrils hop between synapses to spread throughout the brain, prompted by Aβ aggregates and overactive neurons. New imaging and biomarker data add weight to this theory. In the January 3 Nature Communica

2023—A Bumper Year for the Treatment and Science of Alzheimer's

COMMUNITY NEWS 2024-01-12 Community News After decades of effort, setbacks, and dogged steps forward, Alzheimerologists breathed a collective sigh of relief last year with the U.S. FDA’s thumbs-up for Leqembi, the first traditional approval for a disease-modifying immunotherapy fo

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