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New Orleans: Jason Shepherd Reports on New Mouse Models

CONFERENCE COVERAGE 2003-12-05 Conference Coverage Two new approaches for modeling neurodegeneration in mice were unveiled at the 33rd Annual meeting of the Society for Neuroscience in New Orleans. Frank LaFerla ’s group at University of California, Irvine, generated mice in which sele

Radical Development: Reactive Oxygen Species Critical in Development

RESEARCH NEWS 2003-12-04 Research News Reactive oxygen species (ROS) are well-established suspects in aging, atherosclerosis, and neurodegeneration. However, any therapeutic attempts to interfere with these short-lived molecules—which oxidize proteins, lipids, and nucleic acids i

New Orleans: Kelly Dineley Reports from Satellite Social

CONFERENCE COVERAGE 2003-12-03 Conference Coverage This meeting report is anchored by Kelly Dineley, with individual presentations written by the respective investigators. At the 33rd Annual Meeting of the Society for Neuroscience in New Orleans, approximately 100 scientists gathered t

New Orleans: Plant Chemical a Protein Aggregation Buster?

CONFERENCE COVERAGE 2003-12-03 Conference Coverage By Erene Mina. While modern medicine races into the future, it tends to overlook the possibility that remedies might lie in the past. At the 33rd Annual Meeting of the Society for Neuroscience, Anthony Fink and M. Zhu of the University

New Neurons Born among the Dying in Alzheimer’s Hippocampus?

RESEARCH NEWS 2003-12-03 Research News Is the cycle of life—new lives born even as the old die—to be found in the hippocampus of Alzheimer's patients? A study in this week’s online PNAS suggests just this, and poses the question of whether we could spur newly born neurons to

New Orleans: Aβ Oligomers and Memory: Now They Are Good…

CONFERENCE COVERAGE 2003-12-03 Conference Coverage By Erene Mina. As evidence mounts against oligomers as culprits of Aβ neurotoxicity (see ARF related New Orleans story), their only defense hinges on the possibility that they may have some normal physiological function—even a slightly

New Orleans: Aβ Oligomers and Memory: …Now They Are Bad

CONFERENCE COVERAGE 2003-12-03 Conference Coverage Notwithstanding some redeeming features (ARF related New Orleans story) soluble Aβ oligomers have an overwhelmingly bad reputation as suspected mediators of synaptic dysfunction in Alzheimer’s. A number of accusing fingers have pointed

RNAi Struts Its Stuff in Brain, in Vivo

RESEARCH NEWS 2003-11-26 Research News The potential of RNA interference is exciting, offering the possibility of shutting down expression of specific proteins—perhaps in specific cells—for both investigative and therapeutic purposes (see ARF live discussion on this subject). But

Fluorobodies Make Antibodies Green with Envy

RESEARCH NEWS 2003-11-26 Research News Antibodies have proven to be extremely versatile tools for detecting proteins both in vitro and in vivo, but they need to be coupled to an additional label, such as an enzyme, radioisotope, or fluorophore. Now enter the "fluorobody,&quo

New Orleans: Symposium Probes Why Synapses Are Suffering

CONFERENCE COVERAGE 2003-11-25 Conference Coverage Are you sometimes tempted to view APP and presenilin merely as raw material and machine for Aβ production, respectively? If so, think again, because that narrow spotlight is opening up to a broader understanding of how these two protei

New Orleans: Immunotherapy—The Game Is Still in Town

CONFERENCE COVERAGE 2003-11-21 Conference Coverage At the 33rd Annual Meeting of the Society for Neuroscience held last week in New Orleans, at least two dozen presentations dealt with current efforts to develop a vaccine for Alzheimer’s disease. This bold approach suffered a setback l

New Orleans: New Approaches to Lift Microglia Mysteries

CONFERENCE COVERAGE 2003-11-21 Conference Coverage The role of inflammation in Alzheimer’s disease—beyond serious dispute, yet still enigmatic—gained much attention at the 33rd Annual Meeting of the Society for Neuroscience, held last week in New Orleans. While immunotherapy labs are r

Herpes and AD—Virus Hitches Ride with APP

RESEARCH NEWS 2003-11-19 Research News In this month's Aging Cell, researchers show that the herpes simplex virus (HSV), traveling away from the neuronal cell body along axons, is associated with the amyloid precursor protein (APP). This finding offers some new insights into

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