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Alzheimer's Medal Goes to Pioneer in Diffusible Aβ

COMMUNITY NEWS 2003-04-27 Community News Massimo Tabaton of the University of Genoa, Italy, has been awarded this year's Alzheimer's Medal. The award is presented annually by the associate editors of the Journal of Alzheimer's Disease "for the best article publ

Tau and α-synuclein at the Nexus of Alzheimer's and Parkinson's

RESEARCH NEWS 2003-04-24 Research News There is growing interest in the overlap among Alzheimer's disease, Parkinson's disease, and less common synucleinopathies and tauopathies that can share features of both diseases. Two current papers looking at different levels of

Amyloid Oligomer Antibody—One Size Fits All?

RESEARCH NEWS 2003-04-18 Research News Like good cholesterol and bad cholesterol, the Alzheimer's community has realized that there may also be good Aβ and bad Aβ. What if an antibody was developed to target only the latter? A tall order, yet scientists from the University o

Adult Stem Cells Target Inflammation, Replace Cells in MS Model

RESEARCH NEWS 2003-04-17 Research News Stem cells injected into the cerebral ventricles-or even injected intravenously-find their way to sites of inflammation in an animal model of multiple sclerosis (MS), according to a report in today’s Nature. Once there, they replace the dama

AD Cell Cycle Reentry—Early Rather Than Late

RESEARCH NEWS 2003-04-16 Research News What happens when the protein machinery that drives the cell division cycle gets activated in non-dividing cells such as neurons? The cells will most likely die. Recent evidence suggests that just this type of scenario plays out in the brain

Genes and Longevity—Can One Base Pair Make a Difference?

RESEARCH NEWS 2003-04-14 Research News In this month's Journal of Medical Genetics, a group of Italian researchers propose that there is a link between longevity and a single nucleotide polymorphism (SNP) in the promoter for the antiinflammatory cytokine interleukin-10 (IL-1

Annotation of Human Chromosome 7 Reaches Breakpoint

RESEARCH NEWS 2003-04-11 Research News In yesterday’s Sciencexpress, researchers described the most complete annotation of human chromosome 7 to date. Capitalizing on the availability of clinical and medical information from a variety of databases, Stephen Scherer, from The Hospi

Memantine Relieves Symptoms in Moderate to Severe AD

RESEARCH NEWS 2003-04-09 Research News The drug memantine can benefit patients with moderate to severe Alzheimer's disease, according to a study reported in the April 3 New England Journal of Medicine. Memantine has been used for more than a decade to treat dementia in Germa

Prospects for Growth Hormone Therapy Shrink in Alzheimer’s Trial

RESEARCH NEWS 2003-04-09 Research News The hormone dehydroepiandrosterone (DHEA) failed to significantly improve cognition in a small pilot trial of patients with Alzheimer's disease, according to a report in the April issue of Neurology. Funded by the National Institute on

Ceramide Leads to Higher BACE Levels

RESEARCH NEWS 2003-04-05 Research News A paper in press in the Journal of Biological Chemistry reports that the lipid ceramide may contribute to the formation of amyloid deposits found in Alzheimer's disease patients because it stabilizes BACE, one of the enzymes that cleave

Stem Cell Fusion Is for Real

RESEARCH NEWS 2003-04-04 Research News Transplanted blood progenitor cells can help repopulate a diseased liver, but they do this by fusing with existing liver cells, as opposed to reverting to a more pluripotent stem cell identity, according to two reports published online in Na

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