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RESEARCH NEWS 2024-01-30 Research News Variants in the TMEM106b gene influence the risk and severity of frontotemporal dementia, but how? A study published January 17 in Science Translational Medicine suggests that the answer comes down to the lysosomal protein’s propensity to tw
RESEARCH NEWS 2024-01-26 Research News Part 2 of 2. Click here for Part 1. What happens in the brain of a person with fatal ARIA? Researchers now have one of their first detailed looks at the pathology of this rare and calamitous condition. In the December 12 Nature Communication
RESEARCH NEWS 2024-01-26 Research News Part 1 of 2. Click here for Part 2. As Alzheimer’s clinicians across the U.S. started offering a disease-modifying treatment to their patients, uptake at first was slow but is now speeding up. Six months after Eisai’s anti-amyloid antibody l
RESEARCH NEWS 2024-01-25 Research News Not so long ago, a blood test for Alzheimer’s disease seemed a pipe dream. Now, after years of study, the field is awash with sensitive assays that signal the proteopathic culprits Aβ and tau coalescing in the brain. As these blood tests vie
RESEARCH NEWS 2024-01-24 Research News Researchers led by Nicholas Ashton at the University of Gothenburg, Sweden, recently reported that ALZpath Inc.’s plasma phospho-tau217 assay detected amyloid and tau positivity with 92 to 97 percent accuracy. Now, the data is peer-reviewed
RESEARCH NEWS 2024-01-24 Research News Cholesterol clears the brain once metabolized to 24-hydroxycholesterol, but that is not the only way 24HC can be beneficial, according to Silvia Maioli at the Karolinska Institutet in Stockholm. In the January 24 Science Advances, Maioli and
RESEARCH NEWS 2024-01-19 Research News When people come to their doctor with memory problems, they tend to want to know if Alzheimer's is to blame and, if so, what they can expect. Answering these questions with a degree of certainty is a tall order, and many view amyloid-PE
RESEARCH NEWS 2024-01-19 Research News The search for a good model of late-onset Alzheimer’s disease continues. Researchers led by Adrian Oblak of the Indiana University School of Medicine in Indianapolis and Gareth Howell at the Jackson Laboratory (JAX), Bar Harbor, Maine, have
RESEARCH NEWS 2024-01-17 Research News Most phospho-tau fluid biomarkers validated so far track more tightly with amyloid plaques than they do with tau tangles. A new study published January 6 in Acta Neuropathologica confirms that p-tau205 breaks that mold. In the cerebrospinal
RESEARCH NEWS 2024-01-17 Research News Some scientists believe that toxic tau fibrils hop between synapses to spread throughout the brain, prompted by Aβ aggregates and overactive neurons. New imaging and biomarker data add weight to this theory. In the January 3 Nature Communica
COMMUNITY NEWS 2024-01-12 Community News After decades of effort, setbacks, and dogged steps forward, Alzheimerologists breathed a collective sigh of relief last year with the U.S. FDA’s thumbs-up for Leqembi, the first traditional approval for a disease-modifying immunotherapy fo
RESEARCH NEWS 2024-01-05 Research News Neurons intertwine with small blood vessels in the brain, but how do the two communicate? With elaborate three-dimensional reconstructions of electron microscopy images, scientists led by Jie-Min Jia, Westlake University in Hangzhou, China,
RESEARCH NEWS 2024-01-05 Research News Health and lifestyle influence the risk of late-onset dementia. Is this true when disease begins before age 65? Yes, according to researchers led by Stevie Hendriks and Sebastian Köhler, Maastricht University, the Netherlands. In the Decembe
RESEARCH NEWS 2023-12-28 Research News Anyone on the heart failure drug Entresto who tests positive for Alzheimer’s disease based on blood Aβ42/40 might not want to panic. That’s because the drug can lower the amyloid ratio three times more than does brain amyloidosis. This is ac
RESEARCH NEWS 2023-12-27 Research News Although researchers know that most of the genetic risk for late-onset Alzheimer’s disease resides in microglia, exactly how these genes work their mischief remains something of a black box. In the November 29 Nature Communications, research
