SEARCH RESULTS

6112 RESULTS

New Alzheimer Research Consortium Invites Grant Applications

RESEARCH NEWS 2003-09-26 Research News A novel public-private consortium designed to combat Alzheimer’s disease by supporting the development of new animal models is seeking grant applications from scientists at universities and independent research institutes worldwide. Models d

Memantine One Step Shy of US Approval

RESEARCH NEWS 2003-09-25 Research News The Food and Drug Administration’s advisory committee on peripheral and central nervous system drugs yesterday narrowly recommended that the FDA approve memantine (see ARF Drugs in Clinical Trials) for advanced stages of Alzheimer’s disease.

Biomarker Bonus: Phospho-Tau/Aβ Ratio Increase Sensitivity

RESEARCH NEWS 2003-09-23 Research News The ratio of phosphorylated tau (p-tau) to β-amyloid (Aβ) in the cerebrospinal fluid improves the ability to distinguish clinically defined Alzheimer's patients from normal subjects, according to a study in the September issue of the Ar

Acetylcholinesterase—Enzyme or Fibril Former?

RESEARCH NEWS 2003-09-23 Research News Acetylcholinesterase (AChE), best known for hydrolyzing the neurotransmitter acetylcholine, is also found in the amyloid plaques that plague the brains of Alzheimer's patients. What part this protein has in progression of AD is unclear,

Donepezil to Broaden Its Reach?

RESEARCH NEWS 2003-09-19 Research News Two similar studies funded by Eisai and Pfizer companies, the developer and US-promoter of the acetylcholinesterase inhibitor drug donepezil, suggest that their drug, already widely used for the treatment of Alzheimer’s disease, may also rel

Oxidative Damage to the Olfactory Epithelium—Smells Like AD

RESEARCH NEWS 2003-09-17 Research News Could biopsy of olfactory epithelium yield early warnings of Alzheimer's disease (AD)? This possibility was raised by George Perry and colleagues who report in the August 29 online issue of Acta Neuropathologica that oxidative damage to

Pinning Prions to the Cytosol

RESEARCH NEWS 2003-09-17 Research News Prions, those self-replicating proteins that are responsible for scrapie, mad cow disease, and human neurologic diseases such as Creutzfeldt-Jakob and Kuru, have been notoriously difficult to pin down in the cell. Now, an international colla

Alzheimer's Drug Discovery Award for 2003

RESEARCH NEWS 2003-09-16 Research News The scientist who helped discover one of the few drugs currently approved for the treatment of Alzheimer's disease has received the $100,000 Alzheimer's Drug Discovery Award for 2003. Marta Weinstock and colleagues at the Hebrew Un

Outlook for PPARγ Agonists Not So Rosi

RESEARCH NEWS 2003-09-13 Research News Hope that thiazolidinedione agonists of PPARγ (Peroxisome Proliferator Activated Receptor-γ) will prove beneficial for Alzheimer's patients (see ARF recent live discussion) may be tempered slightly by a report in this week's Mayo C

Enabling Technologies 2003 Workshop Summary

CONFERENCE COVERAGE 2003-09-08 Conference Coverage Overview The first day of Enabling Technologies 2003 focused on the natural history of Alzheimer's disease, fundamental cell biology, and mechanisms of neurodegeneration. On the second day, workshop participants reviewed the curre

Recommendations: A Report from Bar Harbor 2003

CONFERENCE COVERAGE 2003-09-08 Conference Coverage 1. Conduct mechanistic studies to determine what Ab oligomers do in the synaptic cleft: how do they affect calcium metabolism and synapse function when applied from outside to normal slices of brain tissue or when the oligomers are pro

Does ER Stress Protein Contribute to Biopolar Disorder?

RESEARCH NEWS 2003-09-08 Research News The risk of developing bipolar disorder appears to increase in people who carry a particular polymorphism of a transcription factor that aids in the clearance of "junk" protein from the endoplasmic reticulum. In the online edition

MHC Polymorphisms Influence Immune Response to Amyloid β

RESEARCH NEWS 2003-09-05 Research News Genetic polymorphisms in the major histocompatibility complex (MHC)—a group of proteins that help the immune system distinguish self from non-self—can profoundly influence the immune response mounted against an amyloid β vaccine. That is the

Measuring Protein Folding One Molecule at a Time

RESEARCH NEWS 2003-08-29 Research News Scientists have long puzzled over the following conundrum: If the activity of a protein solution drops by half, have half the molecules completely lost activity, or have all the proteins lost half their activity? The answer, most likely, is

Current Filters

  • TYPE: News x
  • Date Range : All x

Remove all filters

Filter By

DATE RANGE
  • All
  • Past 7 Days
  • Past 30 Days
  • Past 90 Days
  • Past 12 Months
  • Specific Dates
    1. From
      To

TYPE
TYPE OF NEWS
DISEASE
TOPIC
BIOMOLECULE