6120 RESULTS
RESEARCH NEWS 2004-03-04 Research News The triplet repeat disease X-linked spinal and bulbar muscular atrophy (SBMA) is caused by a polyglutamine expansion in the androgen receptor (AR) gene. Just how this expansion causes degeneration of lower motor neurons is unclear, but in to
RESEARCH NEWS 2004-03-04 Research News PAR-1, a homologue of microtubule-affinity regulating kinase (MARK), kicks off the phosphorylation events that culminate in cell death in a fly model of tauopathy, according to a report in today’s issue of Cell by Bingwei Lu and colleagues.
RESEARCH NEWS 2004-03-02 Research News DNA makes RNA makes protein. That's how the dogma goes. But it doesn't always work out that way. In a minority of cases the DNA code is actually rewritten through RNA editing. In the February 26 Nature, Shin Kwak and colleagues at
RESEARCH NEWS 2004-03-01 Research News Where there is more BACE, there is more Aβ. In the current online Early Edition of PNAS, Rena Li, Yong Shen, and their collaborators at Sun Health Research Institute in Sun City, Arizona, show that increased BACE expression and activity corr
RESEARCH NEWS 2004-03-01 Research News Amyloidoses are a varied and complex set of syndromes caused by aggregation of specific proteins such as the amyloid-β, found in the brains of Alzheimer's patients, and transthyretin, which is found in a variety tissues damaged by syste
RESEARCH NEWS 2004-03-01 Research News As drug discovery in AD research is shifting from inhibiting the γ-secretase to inhibiting the β-secretase (BACE), interest in the entire life cycle of BACE has grown, concomitantly. In the current online Early Edition of PNAS, Vincent Mauro
RESEARCH NEWS 2004-02-20 Research News The Reuters news agency reported today that Eli Lilly and Co. has notified doctors of a significant increase in the risk for stroke and death that it has observed in demented elderly patients who take its drug Zyprexa. This antipsychotic is
RESEARCH NEWS 2004-02-19 Research News Amyloid-β precursor protein (AβPP) has gained a notorious reputation because it releases the Aβ peptide that gums up intraneuronal spaces in Alzheimer's brains. Like many of notoriety, however, AβPP probably has a good side, as well, be
RESEARCH NEWS 2004-02-19 Research News Finding a working ATM when you’re short of cash can be a life-saver. If you are a neuron, however, you may want to keep your ATM out of order because the currency it dishes out can be lethal. In today’s Neuron, researchers report that ATM, o
RESEARCH NEWS 2004-02-17 Research News Add a new strand to the growing web of relationships among production of the Aβ peptide, regulation of cholesterol and other lipids, oxidative stress, and the death of neurons in Alzheimer's. Mark Mattson and colleagues at the National
RESEARCH NEWS 2004-02-15 Research News The sliver of brain called striatum plays a key role in integrating dopaminergic inputs from the midbrain and glutamatergic inputs from the thalamus and neocortex, a job that enables a person to process motor- and reward-related behaviors pr
RESEARCH NEWS 2004-02-12 Research News Individually, both nitric oxide (NO) and zinc (Zn+) have been implicated in triggering neurodegeneration (see related news for NO) and Zn2+). But who would have thought that the two small molecules act in concert to activate apoptosis? That&
RESEARCH NEWS 2004-02-12 Research News Updated 21 January 2005: Science magazine has formally retracted this paper because its data were fabricated; see ARF related news story. 12 February 2004. Researchers in South Korea have apparently cloned the first human embryo. Perhaps equ
RESEARCH NEWS 2004-02-08 Research News Check out the newest gene microarray results in the Alzheimer's brain, and see if they give a lift to some of your favorite hypotheses and molecular suspects. The study, by Eric Blalock, Philip Landfield, and colleagues at the Universit
RESEARCH NEWS 2004-02-08 Research News The quest to unveil the mystery of memory and synaptic plasticity—for some years the domain of behavioral biologists and electrophysiologists—has led scientists squarely back to basic molecular biology. Because long-lasting memories require
