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In AD, Effects of Some Genetic Variants Limited to Cell Subtypes

RESEARCH NEWS 2024-03-27 Research News While genome-wide association studies tie variants to disease risk, they don’t explain how those variants influence gene expression or pathology. In the March 21 Nature Genetics, scientists led by Vilas Menon and Philip De Jager at New York’

CSF Hugs Arteries to Squeeze into the Brain

RESEARCH NEWS 2024-03-26 Research News The space between the arachnoid and pia meningeal layers encasing the brain is a landscape of connective tissue, blood vessels, and cerebrospinal fluid. Scientists debate how that fluid moves within the space and through brain tissue. Now, a

Therapeutic Contenders Target Hard-to-Reach Pockets of Tau

CONFERENCE COVERAGE 2024-03-23 Conference Coverage At this year’s AD/PD meeting, held March 5-9 in Lisbon, Portugal, no splashy Phase 3, or even Phase 2, data on tau-targeted therapies wowed attendees. Still, Phase 1 and preclinical data showcased a variety of therapeutic approaches th

TREM1 Muddles Myeloid Cell Metabolism and Memory in Old Mice

RESEARCH NEWS 2024-03-21 Research News The macrophage and microglial receptor TREM1 whips up inflammation. In its tizzy, the receptor also perturbs myeloid cell metabolism and hastens cognitive decline in older wild-type mice and in two models of amyloidosis, according to scienti

Reverse Electron Flow in Microglia Linked to Neuroinflammation

RESEARCH NEWS 2024-03-20 Research News Brain lesions beset with smoldering inflammation, and myeloid cells around their edges, define multiple sclerosis. This might be due, in part, to the flipping of electron flow within microglia, propose Luca Peruzzotti-Jametti, Stefano Pluchi

Paper Alert: APOE4 Packs on Lipid Droplets in Microglia

RESEARCH NEWS 2024-03-13 Research News Last year, scientists led by Tony Wyss-Coray, Stanford University, reported that Aβ induced formation of lipid droplets within human microglia, and attributed this to an uptick in a triglyceride synthesis enzyme. APOE4 aggravated lipid dropl

HIV Drug Safe in Alzheimer’s Pilot Trial, Nudged Biomarkers

RESEARCH NEWS 2024-03-12 Research News Almost half of a person's DNA consists of retrotransposons, remnants of ancient viral infections that have jumped around the human genome. Retrotransposons are typically kept under wraps by epigenetics, but tau can unleash those restrai

Nearly Two Years After FDA Approval, Relyvrio Bombs Phase 3 for ALS

RESEARCH NEWS 2024-03-08 Research News Enticing a reluctant FDA Advisory Committee to greenlight its drug based solely on Phase 2, Amylyx Pharmaceuticals promised, sort of, that if its ongoing Phase 3 trial returned negative results, it would voluntarily withdraw the drug. Those

Neuroprotective Extracellular Matrix Seen in C9ORF72 ALS/FTD Models

RESEARCH NEWS 2024-03-07 Research News Amyotrophic lateral sclerosis and frontotemporal dementia are heterogeneous diseases that are difficult to fully model in mice. One of the more common forms is caused by hexanucleotide repeat expansion in the gene C9ORF72, which prompts both

Do Sleep Rhythms Create Ion Waves That Rinse the Brain?

RESEARCH NEWS 2024-03-05 Research News During sleep, the brain cleans itself, turning up the flow of cerebrospinal fluid through the gray matter parenchyma to wash away waste. What powers this flow? In the February 28 Nature online, researchers led by Jonathan Kipnis at Washingto

More on Moribund Mitochondrial Respiration Prior to Plaques

RESEARCH NEWS 2024-03-05 Research News The brain's metabolism starts to wane decades before Alzheimer's symptoms. Why the energy deficit? Scientists led by Andrés Norambuena and George Bloom at the University of Virginia, Charlottesville, blame failure of a specific typ

Tau Fragments in Plasma Track with Tangles, Cognitive Decline

RESEARCH NEWS 2024-03-01 Research News While numerous fluid markers flag brain Aβ pathology in Alzheimer’s disease, markers of neurofibrillary tangles are few and far between. Now, scientists led by Oskar Hansson at Lund University in Sweden and Juan Lantero-Rodriguez of the Univ

Different Cellular Mechanisms in Familial and Sporadic Alzheimer’s?

RESEARCH NEWS 2024-02-29 Research News How alike are familial and sporadic Alzheimer’s? It depends. Broadly speaking, in terms of their presymptomatic biomarker changes, the two resemble each other closely (see Feb 2024 news). In terms of what goes on inside affected cells, thing

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