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Treat Before ‘Aβ Bothers Tau,’ Scientists Say at CTAD

CONFERENCE COVERAGE 2023-11-08 Conference Coverage Some researchers have long argued for starting amyloid immunotherapy early, before tangles spread and neurons die all over the brain. At the 16th Clinical Trials on Alzheimer’s Disease conference, held October 24 to 27 in Boston and on

To Recruit for Diverse Alzheimer Trials, Go to the People

CONFERENCE COVERAGE 2023-11-05 Conference Coverage Despite evidence that African American, Hispanic and Latino, and other minority groups have higher rates of Alzheimer’s and related dementias in the U.S., these populations are less likely to take part in clinical studies. This underre

Border Surprise: Glia Limitans Astrocytes Sit on Brain Surface

RESEARCH NEWS 2023-11-04 Research News In their growing interest in the brain's border tissues, Alzheimerologists realize that they know little about some of its cells. One new study now sheds light on the astrocytes that form the glia limitans, which separates the brain

Amyloid, Not Vascular Disease, May Drive White-Matter Hyperintensities

RESEARCH NEWS 2023-11-03 Research News Bright spots called white-matter hyperintensities (WMHs) often appear on MRI scans of people with familial or sporadic Alzheimer’s disease, and they tend to intensify as the disease progresses. Some scientists think they reflect cerebrovascu

Is Transgelin-2 a ‘Receptor’ for Soluble TREM2?

RESEARCH NEWS 2023-11-03 Research News Because certain variants in TREM2 increase a person's risk of developing Alzheimer’s disease, how this microglial receptor influences AD pathology is an area of intense investigation. Now, researchers led by Zhentao Zhang, Renmin Hospit

Can Flipping a Lipid Switch Protect the Brain?

CONFERENCE COVERAGE 2023-10-27 Conference Coverage Inflammation can be a helpful response to the common cold or the bite of an insect, but dangerous if it persists. In neurodegeneration, chronic micro- and astrogliosis spell trouble for the brain. Does it have to be that way? Over the

In Amyloid and Tangle Models, APOE4 Paralyzes Microglia

RESEARCH NEWS 2023-10-26 Research News Though APOE4 is the strongest genetic risk factor for sporadic Alzheimer’s disease, scientists have struggled for decades to figure out how it affects the cells of the brain. For microglia, at least, there may be some clarity.  In the Septem

New Therapeutic Strategy—Mimic the ApoE Christchurch Mutation?

RESEARCH NEWS 2023-10-24 Research News People with ApoE3 Christchurch variant  stave off even autosomal-dominant Alzheimer’s disease by keeping neurofibrillary tangles at bay. Could people born without this protective mutation reap its benefits? Researchers led by Joseph Arboleda

Cracking the Cholesterol-AD Code: Metabolites and Cell Type

CONFERENCE COVERAGE 2023-10-21 Conference Coverage Since the 1990s, scientists have known cholesterol is important in Alzheimer's, but they gained little traction in their efforts to understand the relationship between the lipid and the disease. Though amyloid plaques, where the s

Does the Brain Use Microglia to Maintain Its Myelin?

CONFERENCE COVERAGE 2023-10-20 Conference Coverage You might well think that myelin, the fatty insulation that speeds action potentials between neurons, falls solely under the purview of oligodendrocytes. After all, these specialized cells wrap cholesterol-laden myelin around axons in

Cutting (or Slippery?) Edge: Lipids in Neurodegeneration Science

CONFERENCE COVERAGE 2023-10-20 Conference Coverage Readers, ignore lipids at your peril. These oily molecules make up 60 percent of the human brain. Long considered mere wrapping for more interesting cellular contents, these fats hold secrets worth exploring. At the 2nd Symposium on Li

After a Decade, Amyloid PET Scans Receive Broad Insurance Coverage

COMMUNITY NEWS 2023-10-19 Community News Clinical care for Alzheimer’s disease is undergoing a sea change. The latest wave? Eleven years after the first amyloid PET tracer was approved by the U.S. Food and Drug Administration, the scans will be broadly covered for Medicare benefic

Tauopathy Transcriptomes Tell Tantalizing Tales

RESEARCH NEWS 2023-10-18 Research News Fibrillar tau accumulates in several neurodegenerative diseases. Are the same molecular mechanisms responsible, or does each tauopathy follow distinct pathways? Some of both, according to a preprint posted to bioRxiv on September 30. Researc

In Alzheimer’s, Tau Oligomers in Synapses Act as ‘Eat Me’ Signal

RESEARCH NEWS 2023-10-14 Research News Neurofibrillary tangles, the hallmark of tauopathies, are closely linked to failing cognition. So are tau oligomers, suggest scientists led by Teresa Gómez-Isla at Massachusetts General Hospital in Boston. In the October 9 JAMA Neurology, th

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