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CONFERENCE COVERAGE 2023-11-28 Conference Coverage The latest effort to rewrite the diagnostic criteria for Alzheimer’s disease has stirred more than a little controversy. While the proposed revisions have garnered praise from researchers for more accurately reflecting the underlying b
RESEARCH NEWS 2023-11-23 Research News Lipids are the hot new thing in Alzheimer’s research, with mounting evidence linking their dysregulation to amyloidosis, especially in the presence of the APOE4 allele. Now, researchers led by David Holtzman at Washington University in St. L
RESEARCH NEWS 2023-11-22 Research News Nestled within the plasma membrane, γ-secretase trims the ends off membrane proteins. Among its 150 known substrates, none is more famous than APP. The protease chews APPs transmembrane domain to spit out Aβ peptides that aggregate into amyl
CONFERENCE COVERAGE 2023-11-21 Conference Coverage When COVID forced much of the world into virtual work, dementia scientists sped up their ongoing adaptation of cognitive assessments to digital versions (Dec 2021 conference news). How are they performing now? At the Clinical Trials in
CONFERENCE COVERAGE 2023-11-18 Conference Coverage As researchers parse what makes amyloid immunotherapy work, one answer keeps bubbling up: Take out all plaque quickly, so that clinical benefits have time to show up. At last month’s Clinical Trials on Alzheimer’s Disease conference, h
CONFERENCE COVERAGE 2023-11-17 Conference Coverage Can γ-secretase modulators stage a comeback? Scientists led by Irene Gerlach at F. Hoffmann-La Roche, Basel, Switzerland, are banking on it. At this year’s CTAD meeting, held October 24-27 in Boston, they reported that RG6289, a second
RESEARCH NEWS 2023-11-17 Research News Neuritic plaques, tau phosphorylation, microgliosis—of all the ways Aβ42 could doom the brain, few scientists might have suspected that it cripples γ-secretase, the very enzyme that creates it. Yet that is just what monomers do, according to
RESEARCH NEWS 2023-11-17 Research News A massive collaborative effort has shed some light on the mechanisms at work in progressive supranuclear palsy, a neurodegenerative tauopathy that ravages movement, balance, and cognition. In a manuscript posted November 13 on bioRxiv, resea
CONFERENCE COVERAGE 2023-11-11 Conference Coverage Current amyloid immunotherapies poorly enter the brain, with only one in a thousand antibodies getting through. For several years, researchers have been exploring alternate delivery methods that could allow for lower dosing and higher
CONFERENCE COVERAGE 2023-11-10 Conference Coverage While the trials, tribulations, and successes of Aβ immunotherapy were commanding Alzheimerologists' rapt attention, a different anti-amyloid approach has been quietly moving forward on the sidelines. PRI-002—a small molecule that
CONFERENCE COVERAGE 2023-11-09 Conference Coverage As the proteopathic drivers of Alzheimer's disease, Aβ and tau have for decades kept scientists trying to understand which of their isoforms and fragments are most to blame for the memory-robbing pathogenic cascade—and which ones
CONFERENCE COVERAGE 2023-11-08 Conference Coverage Some researchers have long argued for starting amyloid immunotherapy early, before tangles spread and neurons die all over the brain. At the 16th Clinical Trials on Alzheimer’s Disease conference, held October 24 to 27 in Boston and on
CONFERENCE COVERAGE 2023-11-05 Conference Coverage Evidence suggests that ethnoracial groups in the U.S. have different rates of age-related dementias, with Hispanic/Latino and black or African American people generally being more affected and Asian-Americans being less affected than w
CONFERENCE COVERAGE 2023-11-05 Conference Coverage Despite evidence that African American, Hispanic and Latino, and other minority groups have higher rates of Alzheimer’s and related dementias in the U.S., these populations are less likely to take part in clinical studies. This underre
RESEARCH NEWS 2023-11-04 Research News In their growing interest in the brain's border tissues, Alzheimerologists realize that they know little about some of its cells. One new study now sheds light on the astrocytes that form the glia limitans, which separates the brain
