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Stress-Associated Protein Modulates γ-Secretase to Make More Aβ

RESEARCH NEWS 2020-03-21 Research News In the March 17 Science Signaling, researchers led by Yong-Keun Jung at Seoul National University, South Korea, reported a new modulator of γ-secretase that appears to preferentially affect cleavage of amyloid precursor protein. Stress ...

Traveling C9ORF72 Dipepides Jam Proteasomes in Neighboring Neurons

RESEARCH NEWS 2020-03-20 Research News Hexanucleotide expansions in the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia, but how the dipeptide repeats (DPRs) translated from the expansions incite disease still puzzles ...

Alzheimer’s Gene BIN1 Promotes Synaptic Transmission

RESEARCH NEWS 2020-03-18 Research News BIN1, one of the strongest genetic risk factors for late-onset Alzheimer’s disease, encodes a protein that dabbles in many cellular functions, taking a hand in Aβ production, tau propagation, and microglial function. Now, in the March 10 ...

Plaques, Tangles Throw Off the Brain’s Rhythms

RESEARCH NEWS 2020-03-13 Research News Brain rhythms change their tune in people with Alzheimer’s disease, and they do so to the beat of Aβ and tau, according to a study published in Science Translational Medicine on March 11. Researchers led by Keith Vossel and Srikantan ...

Different CSF Phospho-Taus Match Distinct Changes in Brain Pathology

RESEARCH NEWS 2020-03-13 Research News The phosphorylation of tau in the Alzheimer’s brain is not a binary state. It evolves over time, passing through distinct stages that reflect worsening disease, according to a study in the March 11 Nature Medicine led by Randall Bateman and ...

Without TMEM106B, Lysosomal Traffic Jams Wreak Havoc in Neurons

RESEARCH NEWS 2020-03-11 Research News TMEM106b, a gene carrying risk variants for frontotemporal dementia (FTD), coordinates the steady stream of lysosomal traffic along axons, according to a study published March 10 in Cell Reports. Researchers led by Markus Damme of Christian ...

Paper Alert: Mouse TREM2 Antibody Boosts Microglial Plaque Clean-Up

RESEARCH NEWS 2020-03-10 Research News A new antibody turbocharges TREM2, the most ardent supporter of microglia. In mice, that is. According to a study published March 10 in the EMBO Journal, a monoclonal antibody trained against the mouse microglial receptor prevents shedding ...

Tau Receptor Identified on Cell Surface

CONFERENCE COVERAGE 2020-03-07 Conference Coverage Evidence now seems overwhelming that toxic forms of tau spread from cell to cell, causing the characteristic progression of tauopathies such as Alzheimer’s and frontotemporal dementia. But how does tau get from one cell to another? At ...

Primary Tauopathies Get New PET Ligands

CONFERENCE COVERAGE 2020-03-06 Conference Coverage Scientists studying the non-Alzheimer’s disease tauopathies have struggled to find tracers that will bind the particular forms of tau that predominate in those diseases. At Tau2020, held February 12–13 in Washington, D.C., Gil ...

New at Tau2020: PET Detects First Traces of Tangles in Rhinal Cortex

CONFERENCE COVERAGE 2020-03-05 Conference Coverage Tau2020, the first of what may become a regular “pan-tau” conference (see Part 1 of this series), got off to a brisk start February 12–13 in Washington, D.C. Researchers who focus on primary tauopathies, such as progressive ...

Behold the First Human α-Synuclein CryoEM Fibril Structure

CONFERENCE COVERAGE 2020-03-04 Conference Coverage The first high-resolution cryo-EM structures of pathological α-synuclein aggregates were unveiled at Tau2020, a new conference held Feb 12 and 13 in Washington, D.C. (see Part 1 of this series). Michel Goedert, MRC Laboratory of ...

Resilience Redefined: Sharp at Age 100, Still Sharp at 102

RESEARCH NEWS 2020-03-04 Research News For most of us, cognition declines with age, but a few lucky individuals remain sharp even at advanced ages. Is there a way to figure out who is likely to keep their faculties? In the February 26 JAMA Network Open, researchers led by Henne ...

Tau2020: Meeting for Tauopathies Debuts Genetic Variants

CONFERENCE COVERAGE 2020-03-03 Conference Coverage Tau2020, a new international conference on all things—you guessed it—tau, unfolded in Washington, D.C, February 12 to13. This open meeting grew out gatherings of the Tau Consortium held in previous years, which were funded by the ...

How Much Amyloid Will Kick Off Tangles, and Decline?

CONFERENCE COVERAGE 2020-02-29 Conference Coverage As more research groups are conducting brain imaging in Alzheimer’s disease, separately and on different continents, their data nonetheless converge into a confirmation overall of the disease’s basic progression pathway: plaques, then ...

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