6123 RESULTS
RESEARCH NEWS 2004-06-01 Research News Research presented in the May 27 issue of Neuron supports links between ongoing excitatory activity in the neural networks of the hippocampus and adult neurogenesis. Indeed, suggest the authors, this mechanism could underlie both the storage
RESEARCH NEWS 2004-06-01 Research News Chaperones and redox enzymes, such as peroxidases, play major roles in keeping eukaryotic cells free from the ravages of reactive oxygen species (ROS), which are thought to play a pathological role in many neurodegenerative diseases, includi
CONFERENCE COVERAGE 2004-05-27 Conference Coverage Two scientists updated the audience on the continuing workup of patients in Elan’s ill-fated phase II trial of the AN-1792 vaccine. James Nicoll recounted what he got to see firsthand from his perch as a research and diagnostic patholo
CONFERENCE COVERAGE 2004-05-26 Conference Coverage In the study of genetics, bursts of excitement alternate with periods of lulls. John Hardy, of NIH in Bethesda, took advantage of a present lull (i.e., no new genes on offer this time) to integrate current knowledge in neurodegeneratio
CONFERENCE COVERAGE 2004-05-26 Conference Coverage Unlike prion researchers, their colleagues in Alzheimer’s disease have a rich trove of current and potential future drug targets into which they can sink their collective investigative teeth. It is, of course, the APP processing proble
RESEARCH NEWS 2004-05-26 Research News For those who’d like to brush up on their knowledge of protein aggregation diseases, Chris Dobson of the University of Cambridge offers a quick tutorial in tomorrow’s Science. Dobson first raises the specter of acquired Creutzfeldt-Jakob dis
RESEARCH NEWS 2004-05-25 Research News The AD community’s overwhelming focus on β and γ-secretase has all but obscured a third enzyme that clips APP in an alternative, altogether more benign pathway. This ugly duckling is, of course, α-secretase. It has been snubbed partly becaus
RESEARCH NEWS 2004-05-24 Research News Early in the Huntington's disease (HD) process, before mutant huntingtin protein forms aggregates, there may be an opportunity to delay the disease, according to a report published May16 in the advance online edition of Nature Genetics.
CONFERENCE COVERAGE 2004-05-24 Conference Coverage In the waning days of March, researchers from around the world met in St. Moritz to send off the cold season with three days of science and skiing amid the glorious scenery of the Engadine Alps, in one of Switzerland’s most beautiful v
CONFERENCE COVERAGE 2004-05-24 Conference Coverage Anthony Williamson, of the Scripps Research Institute, La Jolla, California, first noted that to make further inroads into the disease, the field sorely needed an atomic structure of PrPsc. He agreed with Weissmann and Aguzzi that one
RESEARCH NEWS 2004-05-14 Research News Stunted dendritic arbors in a subpopulation of hippocampal granule cells are an early sign of Aβ-induced damage, according to a new study of transgenic PDAPP mice in the May 4 PNAS. The authors suggest that this pathology, which pre-dates am
RESEARCH NEWS 2004-05-13 Research News Evidence linking mitochondrial oxidative stress with neurodegeneration has been pouring forth lately (see, for example, ARF related news on Parkinson’s, ARF related news story and ARF related story). But news of novel mechanisms to prevent d
RESEARCH NEWS 2004-05-10 Research News Despite the vastly heterogeneous nature of mammalian brains, researchers are pressing on with gene profiling experiments aimed at identifying potential risk factors for neurodegenerative diseases, including Alzheimer’s disease (AD). Two such
RESEARCH NEWS 2004-05-10 Research News Last week, both ends of the nerve growth factor (NGF) research spectrum advanced by a step. On its fundamental science, an article in Science describes the crystal complex of NGF with one of its receptors, p75, while on the applied front, th
RESEARCH NEWS 2004-05-06 Research News If aggregates of the sticky amyloid-β can contribute to the pathology of Alzheimer’s disease (AD), then maybe unsticking them will help reverse the process. Far-fetched? Luigi Bergamaschini and colleagues have already demonstrated that antic
