6120 RESULTS
RESEARCH NEWS 2004-08-19 Research News Memory loss is one of the most devastating symptoms of Alzheimer’s disease (AD). But are all of these memories gone forever, or are some of them just irretrievable? And how can we find out? In today’s PLoS Biology, Richard Morris and colleag
RESEARCH NEWS 2004-08-18 Research News Forget, for a moment, about the familiar APP mutations that produce excess β amyloid in the brain and cause Alzheimer's disease. There are some mutations that do not cause the full range of AD pathology, despite producing β amyloid pept
RESEARCH NEWS 2004-08-13 Research News Lovers of red wine the world over may once again take comfort from the amazing powers of resveratrol, a grape-derived polyphenol that has been shown to extend lifespan in yeast, worms, and fruit flies, and which activates the deacetylase SIR
RESEARCH NEWS 2004-08-13 Research News Genetic variants of ABCA1 (ATP-binding cassette A1), an ATP-driven transporter that pumps cholesterol out of cells, recently joined the ranks of potential risk factors for late-onset Alzheimer’s disease (see Wollmer et al., 2003 and Katzov e
RESEARCH NEWS 2004-08-13 Research News Try this speculation on for size: Maybe the reason more functional partners for amyloid precursor protein (APP)—whether ligand or receptor—have not yet been found is that one of its major partners turns out to be…APP. Speculative, indeed, bu
RESEARCH NEWS 2004-08-09 Research News Prion diseases and Alzheimer’s have some striking parallels, most notably the role played by amyloidogenic peptides. But they have many differences, too. Cruetzfeld-Jacob, scrapie, and mad cow diseases are all caused by an infectious protein
RESEARCH NEWS 2004-08-05 Research News Feeling good on the outside often helps us feel good on the inside. Could the same be true for neurons? In today’s issue of the journal Neuron, Frank LaFerla and colleagues at the University of California, Irvine, report that antibodies to a
CONFERENCE COVERAGE 2004-07-31 Conference Coverage One of the basic research flavors that wafted pungently through the 9th International Conference on Alzheimer’s Disease and Related Disorders last week in Philadelphia is the growing sense that intraneuronal Aβ may have more of a hand
CONFERENCE COVERAGE 2004-07-28 Conference Coverage If you’ve ever shone a flashlight through your hand and noticed what comes out on the other side, you have seen for yourself why red light could, in theory, make a medium for live diagnostics: It transmits better through thick, scatter
CONFERENCE COVERAGE 2004-07-27 Conference Coverage Brain imaging has emerged as perhaps the most promising source to date of an antecedent marker for Alzheimer's disease. Such a sought-after, tell-tale giveaway that the underlying process is marching along inexorably in people who
RESEARCH NEWS 2004-07-27 Research News A study published yesterday in the online Annals of Neurology provides a glimpse at the complexity involved in the time- and cell-specific neurodegeneration of Huntington's disease. Ole Isacson and his colleagues at Harvard University r
RESEARCH NEWS 2004-07-27 Research News Since the human genome sequence was published, the search for single nucleotide polymorphisms that contribute to disease has ramped up. But what about copy number polymorphisms? To what extent do these occur in the human population, and what
CONFERENCE COVERAGE 2004-07-23 Conference Coverage APP and presenilin mutations cause Alzheimer’s, tau mutations cause tauopathies, and α-synuclein mutations cause Parkinson’s, right? Well, yes, but it’s not nearly that simple. At the 9th International Conference on Alzheimer’s Disease
CONFERENCE COVERAGE 2004-07-22 Conference Coverage Perhaps…yes? At first blush, this is the tentative conclusion one must draw if the results of two presentations yesterday on the formal analysis of Elan’s AN-1792 vaccine are both right. The presentations were part of the 9th Internati
RESEARCH NEWS 2004-07-22 Research News It has been said that Alzheimer’s disease is not about losing your car keys, but about having them in your hand and not knowing what they do. Such long-term memory (LTM) shortcomings are what we all fear most about this terrible disease. The
