6120 RESULTS
RESEARCH NEWS 2004-12-13 Research News The link between protein aggregation and neurodegenerative diseases is certainly a hot topic these days, awash with questions over whether reducing aggregation is a good idea, and if it is, what aggregates should be targeted. Perhaps just th
RESEARCH NEWS 2004-12-08 Research News Two articles from the past week describe very different approaches to therapy for Parkinson disease (PD). A paper published 2 December in PNAS went close to the root of the problem, reporting that overexpression of parkin from cDNA delivered
CONFERENCE COVERAGE 2004-12-05 Conference Coverage This report summarizes discussions and recommendations made at the fourth annual workshop on Enabling Technologies for Alzheimer's disease (AD), held in August 2004 in Bar Harbor, Maine. Academic and industry scientists from insid
CONFERENCE COVERAGE 2004-12-05 Conference Coverage Axonal Transport Larry Goldstein, of University of California, San Diego, laid out his hypothesis that defects in axonal transport could starve the nerve terminal of needed supplies and lead to synaptic dysfunction in AD, Huntington�
CONFERENCE COVERAGE 2004-12-05 Conference Coverage List of Final Recommendations 1. Make better mouse models. Create strains with only subtle overexpression under endogenous promoter and authentic spatiotemporal regulation, such as YAC. Recreate humanized APP rat unavailable from Cepha
RESEARCH NEWS 2004-12-03 Research News Among its many reputed transgressions, amyloid-β is suspected of interfering with synaptic function from the earliest stages of Alzheimer disease (see ARF related news story). A study published in the December issue of the Journal of Clinica
RESEARCH NEWS 2004-12-02 Research News Different isoforms of glycogen synthase kinase-3 (GSK-3) have been linked to Alzheimer disease (AD). The β variant is one of several kinases that phosphorylate the microtubule-associated protein tau (see ARF related news story), which, when
RESEARCH NEWS 2004-11-29 Research News Ubiquitination, sumoylation (tagging with small ubiquitin-like modifiers), ubiquitinated aggregates, and problems with ubiquitin-mediated proteasomal degradation have all been linked to pathological processes that underlie various neurodegen
RESEARCH NEWS 2004-11-29 Research News There have been several lines of evidence, some anecdotal, suggesting that antibiotics can slow the rate of progression of neurodegenerative disorders, including Alzheimer (see ARF related news story) and Parkinson diseases (see ARF related
RESEARCH NEWS 2004-11-24 Research News Surveying the protein profile of a tissue or body fluid by traditional methods—separating proteins by 2D gels and then analyzing the spots by mass spectrometry—has not proven a very efficient way to detect changes in protein levels in neurod
CONFERENCE COVERAGE 2004-11-23 Conference Coverage Since the discovery that one peptide, amyloid-β, is the major constituent of amyloid plaques, there has been a tremendous focus on the N-terminal end of amyloid-β precursor protein (AβPP). But as emphasized at the 34th annual meeting o
RESEARCH NEWS 2004-11-23 Research News Fragile X mental retardation, the most common form of inherited mental impairment, is caused by mutations in the fmr-1 gene, coding for fragile X mental retardation protein (FMRP). A body of circumstantial evidence has suggested that neurona
RESEARCH NEWS 2004-11-23 Research News Imagine being able to turn on and off an individual neuron remotely—without prodding it with electrodes or challenging it with chemicals. Sound like a neuroscientist's dream? Well, maybe we need to be pinched, because in the November Na
RESEARCH NEWS 2004-11-22 Research News Defeating the yokozuna, the highest ranked professional sumo wrestlers, is almost impossible. Stopping sumoylation, the modification of proteins with small ubiquitin-like modifiers (SUMO) may be easier. In the November 19 Molecular Cell, Sus
RESEARCH NEWS 2004-11-18 Research News The metabolic syndrome—a constellation of cardiovascular and diabetes risk factors such as abdominal obesity, high blood pressure, and high triglycerides—is associated with an increased risk of cognitive decline, according to a report in the
