CONFERENCE COVERAGE 2023-11-08 Conference Coverage Some researchers have long argued for starting amyloid immunotherapy early, before tangles spread and neurons die all over the brain. At the 16th Clinical Trials on Alzheimer’s Disease conference, held October 24 to 27 in Boston and on
CONFERENCE COVERAGE 2023-11-05 Conference Coverage Evidence suggests that ethnoracial groups in the U.S. have different rates of age-related dementias, with Hispanic/Latino and black or African American people generally being more affected and Asian-Americans being less affected than w
CONFERENCE COVERAGE 2023-11-05 Conference Coverage Despite evidence that African American, Hispanic and Latino, and other minority groups have higher rates of Alzheimer’s and related dementias in the U.S., these populations are less likely to take part in clinical studies. This underre
RESEARCH NEWS 2023-11-04 Research News In their growing interest in the brain's border tissues, Alzheimerologists realize that they know little about some of its cells. One new study now sheds light on the astrocytes that form the glia limitans, which separates the brain
RESEARCH NEWS 2023-11-03 Research News Bright spots called white-matter hyperintensities (WMHs) often appear on MRI scans of people with familial or sporadic Alzheimer’s disease, and they tend to intensify as the disease progresses. Some scientists think they reflect cerebrovascu
RESEARCH NEWS 2023-11-03 Research News Because certain variants in TREM2 increase a person's risk of developing Alzheimer’s disease, how this microglial receptor influences AD pathology is an area of intense investigation. Now, researchers led by Zhentao Zhang, Renmin Hospit
CONFERENCE COVERAGE 2023-10-27 Conference Coverage Inflammation can be a helpful response to the common cold or the bite of an insect, but dangerous if it persists. In neurodegeneration, chronic micro- and astrogliosis spell trouble for the brain. Does it have to be that way? Over the
RESEARCH NEWS 2023-10-26 Research News Though APOE4 is the strongest genetic risk factor for sporadic Alzheimer’s disease, scientists have struggled for decades to figure out how it affects the cells of the brain. For microglia, at least, there may be some clarity. In the Septem
RESEARCH NEWS 2023-10-24 Research News People with ApoE3 Christchurch variant stave off even autosomal-dominant Alzheimer’s disease by keeping neurofibrillary tangles at bay. Could people born without this protective mutation reap its benefits? Researchers led by Joseph Arboleda
CONFERENCE COVERAGE 2023-10-21 Conference Coverage Since the 1990s, scientists have known cholesterol is important in Alzheimer's, but they gained little traction in their efforts to understand the relationship between the lipid and the disease. Though amyloid plaques, where the s
CONFERENCE COVERAGE 2023-10-20 Conference Coverage You might well think that myelin, the fatty insulation that speeds action potentials between neurons, falls solely under the purview of oligodendrocytes. After all, these specialized cells wrap cholesterol-laden myelin around axons in
CONFERENCE COVERAGE 2023-10-20 Conference Coverage Readers, ignore lipids at your peril. These oily molecules make up 60 percent of the human brain. Long considered mere wrapping for more interesting cellular contents, these fats hold secrets worth exploring. At the 2nd Symposium on Li
RESEARCH NEWS 2023-10-18 Research News Fibrillar tau accumulates in several neurodegenerative diseases. Are the same molecular mechanisms responsible, or does each tauopathy follow distinct pathways? Some of both, according to a preprint posted to bioRxiv on September 30. Researc
RESEARCH NEWS 2023-10-14 Research News Neurofibrillary tangles, the hallmark of tauopathies, are closely linked to failing cognition. So are tau oligomers, suggest scientists led by Teresa Gómez-Isla at Massachusetts General Hospital in Boston. In the October 9 JAMA Neurology, th