6120 RESULTS
CONFERENCE COVERAGE 2004-05-26 Conference Coverage In the study of genetics, bursts of excitement alternate with periods of lulls. John Hardy, of NIH in Bethesda, took advantage of a present lull (i.e., no new genes on offer this time) to integrate current knowledge in neurodegeneratio
CONFERENCE COVERAGE 2004-05-26 Conference Coverage Unlike prion researchers, their colleagues in Alzheimer’s disease have a rich trove of current and potential future drug targets into which they can sink their collective investigative teeth. It is, of course, the APP processing proble
RESEARCH NEWS 2004-05-26 Research News For those who’d like to brush up on their knowledge of protein aggregation diseases, Chris Dobson of the University of Cambridge offers a quick tutorial in tomorrow’s Science. Dobson first raises the specter of acquired Creutzfeldt-Jakob dis
RESEARCH NEWS 2004-05-25 Research News The AD community’s overwhelming focus on β and γ-secretase has all but obscured a third enzyme that clips APP in an alternative, altogether more benign pathway. This ugly duckling is, of course, α-secretase. It has been snubbed partly becaus
RESEARCH NEWS 2004-05-24 Research News Early in the Huntington's disease (HD) process, before mutant huntingtin protein forms aggregates, there may be an opportunity to delay the disease, according to a report published May16 in the advance online edition of Nature Genetics.
CONFERENCE COVERAGE 2004-05-24 Conference Coverage In the waning days of March, researchers from around the world met in St. Moritz to send off the cold season with three days of science and skiing amid the glorious scenery of the Engadine Alps, in one of Switzerland’s most beautiful v
CONFERENCE COVERAGE 2004-05-24 Conference Coverage Anthony Williamson, of the Scripps Research Institute, La Jolla, California, first noted that to make further inroads into the disease, the field sorely needed an atomic structure of PrPsc. He agreed with Weissmann and Aguzzi that one
RESEARCH NEWS 2004-05-14 Research News Stunted dendritic arbors in a subpopulation of hippocampal granule cells are an early sign of Aβ-induced damage, according to a new study of transgenic PDAPP mice in the May 4 PNAS. The authors suggest that this pathology, which pre-dates am
RESEARCH NEWS 2004-05-13 Research News Evidence linking mitochondrial oxidative stress with neurodegeneration has been pouring forth lately (see, for example, ARF related news on Parkinson’s, ARF related news story and ARF related story). But news of novel mechanisms to prevent d
RESEARCH NEWS 2004-05-10 Research News Despite the vastly heterogeneous nature of mammalian brains, researchers are pressing on with gene profiling experiments aimed at identifying potential risk factors for neurodegenerative diseases, including Alzheimer’s disease (AD). Two such
RESEARCH NEWS 2004-05-10 Research News Last week, both ends of the nerve growth factor (NGF) research spectrum advanced by a step. On its fundamental science, an article in Science describes the crystal complex of NGF with one of its receptors, p75, while on the applied front, th
RESEARCH NEWS 2004-05-06 Research News If aggregates of the sticky amyloid-β can contribute to the pathology of Alzheimer’s disease (AD), then maybe unsticking them will help reverse the process. Far-fetched? Luigi Bergamaschini and colleagues have already demonstrated that antic
RESEARCH NEWS 2004-05-01 Research News Just when many stem cell researchers had given up the ghost on the potential for adult stem cells to transdifferentiate into cells of other lineages, along comes new data to rekindle the debate. Reporting in tomorrow’s Lancet, Edward Scott a
RESEARCH NEWS 2004-04-22 Research News The clamp, the boot, whatever you call it, if you find one on your car you’ll appreciate how a seemingly small attachment can keep its wheels from turning. In today’s Sciencexpress, Ted and Valina Dawson and colleagues at Johns Hopkins Unive
RESEARCH NEWS 2004-04-22 Research News Do solitary Aβ peptides begin their journey toward insoluble plaques by meeting up with partners on lipid rafts in the plasma membrane? Steve Younkin and colleagues report evidence that, in an APP-transgenic mouse model, Aβ dimerizes in the
