6120 RESULTS
RESEARCH NEWS 2004-11-18 Research News Phosphorylation of the microtubule-associated protein tau may be a good thing because it can speed up microtubule transport (see ARF related news story), but abnormal phosphorylation causes the protein to form paired-helical fragments, leadi
RESEARCH NEWS 2004-11-18 Research News Television shows about medical examiners and psychological profilers are all the rage these days. Wouldn't you like to see one about “cytological” profilers? No, not Alois Alzheimer in a period drama, peering at plaques and tangles thro
COMMUNITY NEWS 2004-11-13 Community News As many of our readers are aware, there has been a running court battle between Elan Inc., Dublin, Ireland, and the Mayo Foundation for Medical Education and Research over patents for transgenic mice that are used to model Alzheimer disease
RESEARCH NEWS 2004-11-12 Research News An important RNA interference (RNAi) milestone—the silencing of a therapeutically relevant endogenous gene in an animal model by systemic administration of short interfering (si) RNAs—was reported today in Nature. Researchers at the biotech
RESEARCH NEWS 2004-11-11 Research News Ever since mammalian adult neurogenesis was confirmed, scientists had hoped to get pluripotent cells of the subventricular zone (SVZ) to become something other than olfactory bulb neurons when they mature. That hope was recently realized whe
CONFERENCE COVERAGE 2004-11-10 Conference Coverage ApoE, the major lipoprotein of the brain, is one of the strongest risk factors for late-onset Alzheimer disease (AD), a fact that no doubt spurred the ApoE minisymposium at the 34th annual meeting of the Society for Neuroscience in San
CONFERENCE COVERAGE 2004-11-08 Conference Coverage The more scientists learn about γ-secretase, the crazier it looks to them, according to Todd Golde of the Mayo Clinic in Jacksonville, Florida. Golde is but one of many avid students of this eccentric enzyme, which slices the APP prote
RESEARCH NEWS 2004-11-05 Research News If your plaque-busting molecule is too small to prevent amyloid formation, have it bring along a bigger buddy. This is a strategy that has shown some promise, as reported in the 29 October 2004 issue of Science. Isabella Graef and her collea
CONFERENCE COVERAGE 2004-11-03 Conference Coverage A mouse model that mimics both signature pathologies of Alzheimer disease develops a day-to-day forgetfulness at four months, a young adult age when the animals' brains accumulate the Aβ peptide inside their neurons but don’t yet
CONFERENCE COVERAGE 2004-10-30 Conference Coverage Next time you ponder the pros and cons of coal burning power plants, consider this: Mitochondria, our cellular power plants, do a great job keeping us supplied with ATP, but they, too, have emission problems. As electrons cascade down
RESEARCH NEWS 2004-10-29 Research News Biochemists, cell and molecular biologists, start your engines! You now have another Parkinson protein challenge. The gene that causes PARK8 Parkinson disease has been cloned by a team of researchers from Spain, England, and the United State
RESEARCH NEWS 2004-10-27 Research News Because insulin degrading enzyme (IDE) also degrades Aβ (as well as the AβPP intracellular domain), it has come under intense scrutiny in AD research recently (see ARF related news story and Gabrielle Strobel's review of Aβ degradation
CONFERENCE COVERAGE 2004-10-26 Conference Coverage Drug cocktails have transformed HIV infection from a deadly to a chronic disease, giving HIV carriers a new lease on life. But new long-term consequences of harboring the virus and of taking powerful drugs indefinitely keep cropping up
CONFERENCE COVERAGE 2004-10-24 Conference Coverage Venturing off the beaten path, Bryce Carey yesterday presented a poster at the 34th annual conference of the Society for Neuroscience about the interaction between an MCH class 1 protein and γ-secretase. The list of substrates for this
CONFERENCE COVERAGE 2004-10-24 Conference Coverage Which genes are responsible for the known phenomenon that cholinergic neurons in Alzheimer disease and Down syndrome die because they can’t get their daily fix of nerve growth factor? APP is a natural suspect when it comes to shared fe
