PAPER Schirmer L, Velmeshev D, Holmqvist S, Kaufmann M, Werneburg S, Jung D, Vistnes S, Stockley JH, Young A, Steindel M, Tung B, Goyal N, Bhaduri A, Mayer S, Engler JB, Bayraktar OA, Franklin RJ, Haeussler M, Reynolds R, Schafer DP, Friese MA, Shiow LR, Kriegstein AR, Rowitch DH

Neuronal vulnerability and multilineage diversity in multiple sclerosis.

Nature. 2019 Sep;573(7772):75-82. Epub 2019 Jul 17 PubMed: 31316211

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Swine flu snipers, Alzheimer's drug push and Google's latest gaming bot.

Nature. 2019 Oct;574(7780):602-603. PubMed: 31666725

PAPER Faraco G, Hochrainer K, Segarra SG, Schaeffer S, Santisteban MM, Menon A, Jiang H, Holtzman DM, Anrather J, Iadecola C

Dietary salt promotes cognitive impairment through tau phosphorylation.

Nature. 2019 Oct;574(7780):686-690. Epub 2019 Oct 23 PubMed: 31645758

PAPER Zullo JM, Drake D, Aron L, O'Hern P, Dhamne SC, Davidsohn N, Mao CA, Klein WH, Rotenberg A, Bennett DA, Church GM, Colaiácovo MP, Yankner BA

Regulation of lifespan by neural excitation and REST.

Nature. 2019 Oct;574(7778):359-364. Epub 2019 Oct 16 PubMed: 31619788

PAPER Abbott A

Fresh push for 'failed' Alzheimer's drug.

Nature. 2019 Oct 25; PubMed: 33097841

PAPER Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, Schwartz S, Albasset S, McManus RM, Tejera D, Griep A, Santarelli F, Brosseron F, Opitz S, Stunden J, Merten M, Kayed R, Golenbock DT, Blum D, Latz E, Buée L, Heneka MT

NLRP3 inflammasome activation drives tau pathology.

Nature. 2019 Nov;575(7784):669-673. Epub 2019 Nov 20 PubMed: 31748742

PAPER Li Z, Wang C, Wang Z, Zhu C, Li J, Sha T, Ma L, Gao C, Yang Y, Sun Y, Wang J, Sun X, Lu C, Difiglia M, Mei Y, Ding C, Luo S, Dang Y, Ding Y, Fei Y, Lu B

Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds.

Nature. 2019 Nov;575(7781):203-209. Epub 2019 Oct 30 PubMed: 31666698

PAPER Zoghbi HY

Strategy to selectively remove mutant proteins could combat neurodegeneration.

Nature. 2019 Nov;575(7781):57-58. PubMed: 31690850

PAPER Steinmetz NA, Zatka-Haas P, Carandini M, Harris KD

Distributed coding of choice, action and engagement across the mouse brain.

Nature. 2019 Dec;576(7786):266-273. Epub 2019 Nov 27 PubMed: 31776518

PAPER Tao P, Sun J, Wu Z, Wang S, Wang J, Li W, Pan H, Bai R, Zhang J, Wang Y, Lee PY, Ying W, Zhou Q, Hou J, Wang W, Sun B, Yang M, Liu D, Fang R, Han H, Yang Z, Huang X, Li H, Deuitch N, Zhang Y, Dissanayake D, Haude K, McWalter K, Roadhouse C, MacKenzie JJ, Laxer RM, Aksentijevich I, Yu X, Wang X, Yuan J, Zhou Q

A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1.

Nature. 2019 Dec 11; PubMed: 31827280

PAPER Burmann BM, Gerez JA, Matečko-Burmann I, Campioni S, Kumari P, Ghosh D, Mazur A, Aspholm EE, Šulskis D, Wawrzyniuk M, Bock T, Schmidt A, Rüdiger SG, Riek R, Hiller S

Regulation of α-synuclein by chaperones in mammalian cells.

Nature. 2020 Jan;577(7788):127-132. Epub 2019 Dec 4 PubMed: 31802003

PAPER Gate D, Saligrama N, Leventhal O, Yang AC, Unger MS, Middeldorp J, Chen K, Lehallier B, Channappa D, De Los Santos MB, McBride A, Pluvinage J, Elahi F, Tam GK, Kim Y, Greicius M, Wagner AD, Aigner L, Galasko DR, Davis MM, Wyss-Coray T

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease.

Nature. 2020 Jan;577(7790):399-404. Epub 2020 Jan 8 PubMed: 31915375

PAPER Heneka MT

An immune-cell signature marks the brain in Alzheimer's disease.

Nature. 2020 Jan;577(7790):322-323. PubMed: 31937952

PAPER

Young-onset Parkinson's disease could take root at birth.

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