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Target Validation

Other Drug discovery and development can bradly follow two different paradigms- physiology based drug discovery and target based discovery.  The main difference between these two paradigms lies in the time point at which the  drug target  is actually identified ...

Disease Genes

Other Disease genes have been identified based on hereditary patterns even before the knowledge of the DNA sequences of the human genome. Following an original founder mutation, these genetically inherited diseases run in families; examples include ...

Disease Mechanism

Other The disease mechanism defines the possible cause or causes of a particular disorder, as well as the path or phenotype of the disease.  Disease mechanisms can be broadly classified into the following groups Defects in distinct genes—genetic disorders ...

Target Discovery

Other Drug discovery and development can broadly follow two different paradigms—physiology based drug discovery and target based discovery. The main difference between these two paradigms lies in the time point at which the  drug target  is actually identified. ...

About Us

Other This is a plcaholder page for "About Us". To be replaced by the actual About Us page ...

Interview with Lisa Genova

Other   Lisa Genova   Still Alice Book Cover "In examining disease, we gain wisdom about anatomy and physiology and biology. In examining the person with disease, we gain wisdom about life."—Oliver Sacks,  The Man Who Mistook His Wife for a Hat. ...

Overview

Other We have developed this special section of the Alzforum website to provide a resource for all who share an intense interest in familial early onset AD (eFAD). We have created this series of articles for patients, family members, doctors and care providers, ...

Interview: A Spouse's Perspective on Clinical Trials for eFAD

Other In this conversation with Gabrielle Strobel, the husband of a 39-year-old woman with early onset familial AD (eFAD) discusses the uncharted territory of clinical trials for eFAD patients. All names are pseudonyms. See our previous interview with this ...

Interview: A Courageous Family

Other Karen Henley has been outspoken about the need for greater awareness, support, and research into early onset Alzheimer disease. In the years after her husband was diagnosed in 2001, at age 36, Karen has appeared on national television, facilitated her ...

Interview: A Diagnostic Odyssey

Other In this conversation with Gabrielle Strobel, the husband of a 39-year-old mother of three recounts how the couple spent nearly 2 years with erroneous diagnoses and useless treatments of his wife's condition until she was correctly diagnosed with ...

How Early Onset Dementia Led to a Historic Discovery

Other When Alois Alzheimer described the case of Auguste D. to an audience of fellow psychiatrists in Tuebingen, Germany, in 1906, what set her case apart was the fact that her dementia appeared before she was 50 years old. Dementia at a more advanced age was ...

What Is Early Onset Familial Alzheimer Disease (eFAD)?

Other By Gabrielle Strobel Definition: What Is eFAD?  Early onset familial Alzheimer disease (eFAD) is hereditary and marked by Alzheimer disease symptoms that appear at an unusually early age. Symptoms can start in a person's thirties, forties, and ...

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