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RESEARCH MODELS Summary These transgenic mice overexpress mutant human LRRK2 throughout the brain via a promoter that drives neuronal-specific expression (Ramonet et al., 2011). Nonetheless, the mutant human protein is also overexpressed in the lung and spleen (Kozina et
RESEARCH MODELS Summary The epsilon-4 allele of Apoliporotein E (APOE4) and the R47H variant of TREM2 have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele. This triple mutant line carrie
RESEARCH MODELS The PLCG2 gene encodes the enzyme phospholipase C gamma 2 (PLCγ2), a mediator of transmembrane signaling in microglia that acts downstream of TREM2. A rare missense variant in this gene, P522R, has been associated with reduced risks of Alzheimer’s disease
RESEARCH MODELS The PLCG2 gene encodes the enzyme phospholipase C gamma 2 (PLCγ2), a mediator of transmembrane signaling in microglia that acts downstream of TREM2. A rare missense variant in this gene, rs72824905 (P522R), is associated with a reduced risk of Alzheimer’s
ANTIBODY monoclonal MC1 laboratory Formerly available through Dr. Peter Davies. For updated information, see AlzAntibodies page linked in Note below. conformation dependent antibody (epitope within aa 312-322) reactivity depends on both the N terminus (amino acids
ANTIBODY monoclonal PHF-1 laboratory Formerly available through Dr. Peter Davies. For updated information, see AlzAntibodies page linked in Note below. Immunogen: paired helical filaments of tau. Epitope: around serine-396 and serine-404 phosphorylated sites. Plea
ANTIBODY monoclonal CP13 laboratory Formerly available through Dr. Peter Davies. For updated information, see AlzAntibodies page linked in Note below. epitope around phospho-serine 202 Detects tau phosphorylated at serine-202. Please see new entry for CP-13 in the
ANTIBODY monoclonal AT8 manufacturer immunogen = partially purified human paired helical filament tau. Protein A affinity purified, PBS, no preservative Recognizes tau protein phosphorylated at both serine 202 (Ser202) and threonine 205 (Thr205). Does not cross-re
RESEARCH MODELS Summary MAPT(H1.0)-GR mice are among a series of models developed by Michael Koob and colleagues at the University of Minnesota, collectively referred to as Gene Replacement – Alzheimer’s Disease (GR-AD) mice. In GR-AD mice, “genes of interest are precise
RESEARCH MODELS Summary MAPT(H1.0*N279K)-GR mice are among a series of models developed by Michael Koob and colleagues at the University of Minnesota, collectively referred to as Gene Replacement – Alzheimer’s Disease (GR-AD) mice. In GR-AD mice, “genes of interest are p
RESEARCH MODELS Summary MAPT(H1.0)-GR mice are among a series of models developed by Michael Koob and colleagues at the University of Minnesota, collectively referred to as Gene Replacement – Alzheimer’s Disease (GR-AD) mice. In GR-AD mice, “genes of interest are precise
RESEARCH MODELS Summary MAPT 10IVS+16 C>T mice are among a series of models developed by Michael Koob and colleagues at the University of Minnesota, collectively referred to as Gene Replacement – Alzheimer’s Disease (GR-AD) mice. In GR-AD mice, “genes of interest are
RESEARCH MODELS Summary MAPT(H2.1)-GR mice are among a series of models developed by Michael Koob and colleagues at the University of Minnesota, collectively referred to as Gene Replacement – Alzheimer’s Disease (GR-AD) mice. In GR-AD mice, “genes of interest are precise
RESEARCH MODELS Summary These transgenic mice, referred to here as WT-OX, overexpress human wild-type LRRK2 using a bacterial artificial chromosome (BAC) (Li et al., 2009). The BAC encodes the entire gene with 29 kb upstream and 42 kb downstream. Expression is controlled
RESEARCH MODELS Overview This knock-in (KI) mouse model was generated by introducing a R1441C missense mutation into the GTPase domain at exon 31 of the mouse Lrrk2 (leucine-rich repeat kinase 2) gene (Tong et al., 2009). As such, this mutation is expressed through the c
