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Trem2 R47H KI (Lamb/Landreth) X APPPS1-21

RESEARCH MODELS Summary R47H is a rare variant in TREM2 that triples the risk of Alzheimer’s disease in heterozygous carriers of this variant. In order to study the effects of R47H TREM2 in the context of amyloidosis, Trem2 +/R47H mice were crossed with APPPS1-21 mice ...

Trem2 R47H KI (Lamb/Landreth)

RESEARCH MODELS Summary R47H is a rare variant in TREM2 that triples the risk of Alzheimer’s disease in heterozygous carriers. To create a mouse model carrying a single copy of R47H Trem2 under the control of its natural regulatory elements, CRISPR/Cas9 was used to ...

Ceacam1 KO/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apoliporotein E (APOE4) and the R47H variant of TREM2 have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele. Ceacam1 (Carcinoembryonic ...

Abca7 KO/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apoliporotein E (APOE4) and the R47H variant of TREM2 have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele. Variants in ABCA7, a member of ...

Abca7*A1527G/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apoliporotein E (APOE4) and the rare R47H variant of TREM2 have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele. The p.A1527G allele of ...

App KO/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apoliporotein E (APOE4) and the R47H variant of TREM2 have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele.  This triple mutant line ...

hAbeta-loxP-KI

RESEARCH MODELS Summary These mice express APP with a “humanized” Aβ sequence. Three point mutations were introduced into exon 14 (exon numbering according to APP 695, with 16 exons) of the mouse App gene, to produce three amino acid substitutions within the Aβ sequence ...

Plcg2*M28L/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apoliporotein E (APOE4) and the R47H variant of TREM2 have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele. Plcg2 (phospholipase C, gamma ...

hAPP/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apoliporotein E (APOE4) and the R47H variant of TREM2 have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele. This triple mutant line ...

Il1rap KO/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apoliporotein E (APOE4) and the R47H variant of TREM2 have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele.  Il1rap (interleukin 1 ...

Plcg2 KO

RESEARCH MODELS Summary Plcg2 (phospholipase C, gamma 2) is highly expressed in microglia, and a rare coding variant, rs72824905 (p.P522R), has been found to decrease AD risk by almost one-third (Sims, et al., 2017). Another rare variant, rs61749044 (p.M28L), was found ...

APOE2 Knock-In (JAX)

RESEARCH MODELS Summary APOE2 KI mice express humanized APOE (isoform 2) from the endogenous Apoe locus. Modification Details APOE2 KI mice were generated by using CRISPR/Cas9 to introduce two point mutations (leading to arginine to cysteine substitutions at amino acids ...

TREM2-BAC

RESEARCH MODELS Summary Loss-of-function mutations in TREM2 cause Nasu-Hakola disease (Paloneva et al., 2002), a rare, autosomal-recessive disorder characterized by bone fractures and early onset frontotemporal dementia (Paloneva et al., 2015), and may confer increased ...

TREM2-BAC X 5xFAD

RESEARCH MODELS Summary Loss-of-function mutations in TREM2 cause Nasu-Hakola disease (Paloneva et al., 2002), a rare, autosomal-recessive disorder characterized by bone fractures and early onset frontotemporal dementia (Paloneva et al., 2015), and may confer increased ...

TDP-43 (Q331K) Knock-In (Line 52)

RESEARCH MODELS Summary TDP-43 pathology characterizes a neurodegenerative disease spectrum that encompasses ALS and FTD. Transgenic mice have been used to study the pathological effects of mutant TDP-43, but the interpretation of their phenotypes is complicated by ...

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