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Bcl-2 (124)

ANTIBODY monoclonal 124 manufacturer cat# M0887 immunogen = synthetic peptide corr. to aa. 41-54 of bcl-2 protein liquid, supernatant, Tris/HCl, azide specific to Bcl-2, 25 kDa IgG<sub>1</sub>κ Cell Death Dako Mouse Immunohistochemistry Human Bcl-2 ...

Tau phos Ser721

ANTIBODY polyclonal manufacturer Cat#<br />sc-16944 immunogen = short aa seq. containing phosphorylated Ser721 of human Tau liquid, PBS, gelatin, azide, affinity purified; blocking peptide sc-16944P Ser721 phosphorylated tau IgG Tau Santa Cruz Goat ...

APPSwe (line C3-3)

RESEARCH MODELS Summary These transgenic mice express a chimeric mouse/human APP carrying the Swedish mutation under the control of the mouse prion protein promoter. This line, C3-3, was generated in parallel with line E1-2, which also expresses APP carrying the Swedish ...

PSEN1 Knock-out

RESEARCH MODELS Summary These mice are deficient in PSEN1. This model is perinatal lethal in homozygouse animals which die shortly after birth, presumably from breathing difficulties due to ribcage deformity (Shen et al., 1997). Gross skeletal malformations and central ...

PS1(M146L)

RESEARCH MODELS Summary The first report of this transgenic line described two lines of mice that overexpress human PSEN1 with the M146L mutation, line 5.1 and line 6.2 (Duff et al., 1996). Line 5.1 has been more extensively characterized, especially in relation to the ...

APP(V717I)

RESEARCH MODELS Modification Details Transgene containing human APP (isoform 695) with the London mutation driven by the Thy1 promoter. Neuropathology Plaques start in the subiculum at ten months, spreading to the frontal cortex as dense and diffuse aggregates. Frequent ...

Tau P301L

RESEARCH MODELS Neuropathology Tau hyperphosphorylation and conformational changes in the brain parenchyma start around seven months. Tangle-like pathology is mainly observed in the brain stem and spinal cord, and to a lesser extent in the midbrain and cerebral cortex ...

APP(V717I) x PS1(A246E)

RESEARCH MODELS Summary These are bigenic mice that overexpress both mutant APP (V717I mutation) and mutant PSEN1 (A246E mutation). They were first generated and described by the laboratory of Fred Van Leuven (Dewachter et al., 2000). The transgenes are coexpressed in ...

Senescence Accelerated Mouse (SAMP8)

RESEARCH MODELS Summary The Senescence Accelerated Mouse-Prone 8 (SAMP8) is a naturally occuring mouse line that displays a phenotype of accelerated aging. While maintaining an inbred AKR/J line in the early 1970's, researchers at Kyoto University became aware that ...

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