New Assay, New Cohorts—Plasma p-Tau181 Looks Even Better

CONFERENCE COVERAGE 2020-04-03 Conference Coverage The conference may be virtual, but the data is real. At the online AAT-ADPD 2020, researchers presented their talks and posters in much that same way as they would have in person—albeit without the open question-and-answer time. Up ...

Tau Receptor Identified on Cell Surface

CONFERENCE COVERAGE 2020-03-07 Conference Coverage Evidence now seems overwhelming that toxic forms of tau spread from cell to cell, causing the characteristic progression of tauopathies such as Alzheimer’s and frontotemporal dementia. But how does tau get from one cell to another? At ...

Primary Tauopathies Get New PET Ligands

CONFERENCE COVERAGE 2020-03-06 Conference Coverage Scientists studying the non-Alzheimer’s disease tauopathies have struggled to find tracers that will bind the particular forms of tau that predominate in those diseases. At Tau2020, held February 12–13 in Washington, D.C., Gil ...

New at Tau2020: PET Detects First Traces of Tangles in Rhinal Cortex

CONFERENCE COVERAGE 2020-03-05 Conference Coverage Tau2020, the first of what may become a regular “pan-tau” conference (see Part 1 of this series), got off to a brisk start February 12–13 in Washington, D.C. Researchers who focus on primary tauopathies, such as progressive ...

Behold the First Human α-Synuclein CryoEM Fibril Structure

CONFERENCE COVERAGE 2020-03-04 Conference Coverage The first high-resolution cryo-EM structures of pathological α-synuclein aggregates were unveiled at Tau2020, a new conference held Feb 12 and 13 in Washington, D.C. (see Part 1 of this series). Michel Goedert, MRC Laboratory of ...

Tau2020: Meeting for Tauopathies Debuts Genetic Variants

CONFERENCE COVERAGE 2020-03-03 Conference Coverage Tau2020, a new international conference on all things—you guessed it—tau, unfolded in Washington, D.C, February 12 to13. This open meeting grew out gatherings of the Tau Consortium held in previous years, which were funded by the ...

How Much Amyloid Will Kick Off Tangles, and Decline?

CONFERENCE COVERAGE 2020-02-29 Conference Coverage As more research groups are conducting brain imaging in Alzheimer’s disease, separately and on different continents, their data nonetheless converge into a confirmation overall of the disease’s basic progression pathway: plaques, then ...

Can PET Match Up Areas of Protein Deposit With Alzheimer’s Symptoms?

CONFERENCE COVERAGE 2020-02-26 Conference Coverage Even though, overall, Alzheimer’s disease robs all people it afflicts of mind and memory, it progresses differently in different people. Its specific symptoms, their sequence, and how fast they worsen can vary quite a bit from one ...

Tau PET: The Field Expands Rapidly

CONFERENCE COVERAGE 2020-02-26 Conference Coverage As the field of Alzheimer’s and related dementias is trying to go all-in on detecting—and targeting—tau pathology, scientists are still grappling with exactly how to deploy PET imaging in the effort. A still-new, and still-limited set ...

PET Tracer Detects Synapse Loss Across Alzheimer’s Brain

CONFERENCE COVERAGE 2020-02-07 Conference Coverage Part 1 of a 2-part story. A PET tracer that lights up synapses is able to detect a loss of connectivity across the Alzheimer’s brain, according to new research presented at the Human Amyloid Imaging conference, held January 15–17 in ...

CTAD Lessons for 2020: More Phase 2 Trials, More Diversity

CONFERENCE COVERAGE 2020-01-09 Conference Coverage What lies ahead for Alzheimer’s therapy development? While anti-amyloid antibodies are at last signaling some success, researchers agree that these expensive—and, thus far, at best modestly effective—biologic drugs can form only part ...

Tau PET Scans Turn Positive When Amyloid Does; Symptoms Follow

CONFERENCE COVERAGE 2020-01-09 Conference Coverage This article was amended on January 10, 2020 Tau PET is prying open a window on when and where neurofibrillary tangles appear as Alzheimer’s progresses. At the 12th Clinical Trials on Alzheimer’s Disease Conference, held December 4–7 ...

At CTAD, Early Failures and Hints of Success, from Small Trials

CONFERENCE COVERAGE 2019-12-29 Conference Coverage Though Aβ-targeted therapies hogged the limelight at this year’s Clinical Trials on Alzheimer’s Disease meeting, held December 4–7 in San Diego, California, a large handful of smaller studies had findings to report, as well. These ...

Going Indirect: Can Therapies Halt Alzheimer’s from Outside the Brain?

CONFERENCE COVERAGE 2019-12-21 Conference Coverage For therapies taking aim at Alzheimer’s disease, exerting an effect in the brain seems critical. And obvious. But according to results on display at 12th Clinical Trials on Alzheimer’s Disease conference, held December 4–7 in San Diego ...

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