NIH Summit Wraps Up with Recommendations for Research

CONFERENCE COVERAGE 2018-06-01 Conference Coverage The third summit on AD since 2012, called NIH Alzheimer's Research Summit 2018: Path to Treatment and Prevention, was scheduled for March 1 and 2 at the institute's Bethesda campus in Maryland. Day one went off without a ...

At AAN, Sights Set on Antisense Therapies for Diseases of the Brain

CONFERENCE COVERAGE 2018-05-25 Conference Coverage In recent years, two antisense oligonucleotide therapies have hit the market, at least nine more are in clinical trials for the treatment of neurologic diseases, and nearly two dozen are in preclinical testing, including ASOs for ...

As RNA Therapies Come of Age, Efficacy Remains Weak

CONFERENCE COVERAGE 2018-05-25 Conference Coverage Recent approvals of antisense therapies for spinal muscular atrophy and Duchenne muscular dystrophy have bolstered hopes for targeting RNA to treat a plethora of neurodegenerative brain disorders. At the 70th annual meeting of the ...

New Alzheimer’s and Parkinson’s Immunotherapy Data at AAN

CONFERENCE COVERAGE 2018-05-04 Conference Coverage For neurodegeneration researchers, highlights at the 2018 conference of the American Academy of Neurology, held April 21–27 in Los Angeles, California, were centiloid analysis of PET scans, the latest cognition update from people ...

Do Immune Responses Promote, or Prevent, Parkinson’s Disease?

CONFERENCE COVERAGE 2018-04-18 Conference Coverage Researchers keep turning up unexpected links between Parkinson’s disease and the immune system. At the first Advances in Alzheimer’s and Parkinson’s Therapies Focus Meeting (AAT-AD/PD), March 15–18 in Turin, Italy, Michael ...

Parkinson’s Treatments Go After Genetic Targets

CONFERENCE COVERAGE 2018-04-17 Conference Coverage Current treatments for Parkinson’s disease target motor symptoms, and do nothing to halt progression or address other aspects of the disease. To get beyond this state of affairs, researchers are targeting the underlying disease ...

Alzheimer’s Incidence is Rising, Not Falling, a Researcher Says

CONFERENCE COVERAGE 2018-04-11 Conference Coverage In the last few years, numerous studies have reported that dementia incidence is falling in the developed world. The drop in new cases has been attributed to better public health, in particular improved blood pressure control, but this ...

News From the PET Front: Early Amyloid Networks and Tau Mystery

CONFERENCE COVERAGE 2018-04-10 Conference Coverage The advent of PET to image Alzheimer’s pathology in people has handed researchers new tools for staging disease during life, but PET also presents mysteries. At the first Advances in Alzheimer’s and Parkinson’s Therapies Focus Meeting ...

DIAN and ADNI Data Say Familial and Sporadic AD Converge

CONFERENCE COVERAGE 2018-04-06 Conference Coverage Some ongoing prevention trials enroll people carrying familial Alzheimer’s disease mutations because they are destined to develop the disease on a predictable timescale. But will findings from these trials generalize to the vastly ...

To Block Tau’s Proteopathic Spread, Antibody Must Attack its Mid-Region

CONFERENCE COVERAGE 2018-04-05 Conference Coverage Remember the epitope debate around therapeutic Aβ antibodies? N-terminal versus mid-region versus C-terminal—which would be most effective? At the Advances in Alzheimer’s and Parkinson’s Therapies Focus Meeting (AAT-AD/PD), held March ...

After Plasma Aβ, Now Plasma P-Tau181 Shows Promise

CONFERENCE COVERAGE 2018-04-05 Conference Coverage Elusive as it has been for years, the goal of a blood test to detect Alzheimer’s disease appears suddenly achievable. First came the debut of two mass spectrometry methods and an ELISA that quantified Aβ in the blood reliably enough to ...

Big Data Was the Big Theme at Shortened NIH Summit

CONFERENCE COVERAGE 2018-03-10 Conference Coverage Scientists gathered on March 1 in Bethesda, Maryland, for the 2018 NIH Alzheimer’s Disease Research Summit, ready to absorb the 82 presentations scheduled over two days. Then a nor’easter forced closure of U.S. government buildings and ...

Is There No End to Tau’s Toxic Tricks?

CONFERENCE COVERAGE 2017-12-28 Conference Coverage Besides the protein aggregates that mark tauopathies, in turns out that mutant forms of tau damage neurons in myriad other ways. Many were scrutinized at the Society for Neuroscience conference, held November 11–15 in Washington, D.C. ...

Gut Microbiome May Modify Neurodegeneration

CONFERENCE COVERAGE 2017-12-22 Conference Coverage At the Society for Neuroscience annual meeting, held November 11–15 in Washington, D.C., scientists presented further hints that bacteria in the gut may influence the symptoms and pathology of Alzheimer’s and other neurodegenerative ...

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