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Memory Slips as Soon as Amyloid Appears, Two Decades Before Dementia

CONFERENCE COVERAGE 2018-08-17 Conference Coverage How early in Alzheimer’s disease does a person’s memory falter? As soon as amyloid starts to build up, according to speakers at the Alzheimer’s Association International Conference in Chicago July 22–26. Even before an amyloid scan ...

Four Immunotherapies Now Banish Amyloid From the Brain

CONFERENCE COVERAGE 2018-08-17 Conference Coverage After years of fits and starts, anti-amyloid immunotherapies are finally hitting their target effectively. At least four drugs have now demonstrated the ability to clear plaques from the brain: aducanumab, gantenerumab, Lilly’s ...

Could Better Blood Pressure Management Preserve Cognition?

CONFERENCE COVERAGE 2018-08-03 Conference Coverage Is 120 the new 140…for systolic blood pressure, that is? The penultimate day of the Alzheimer's Association International Conference 2018, which ran July 20–26 in Chicago, brought some good news on prevention. Researchers reported ...

PET Ligand Lights Up AAIC, May Detect Synapse Loss in AD

CONFERENCE COVERAGE 2018-08-03 Conference Coverage Among Alzheimer’s disease pathologies, synaptic loss correlates best with symptoms, but until now researchers have had no way to measure it in living people. That may be changing, with a new PET ligand that binds synaptic vesicle ...

On Target: Crenezumab Reduces Aβ Oligomers in CSF

CONFERENCE COVERAGE 2018-07-31 Conference Coverage An anti-amyloid antibody reduces levels of Aβ oligomers in the cerebrospinal fluid of most patients tested, according to late-breaking results presented at the Alzheimer’s Association International Conference in Chicago on July 25. In ...

BAN2401 Removes Brain Amyloid, Possibly Slows Cognitive Decline

CONFERENCE COVERAGE 2018-07-26 Conference Coverage The last full day of the Alzheimer's Association International Conference, which ended today in Chicago, saw scientists pack a room the size of an aircraft hangar in anticipation of a late addition to the scientific program. They ...

VCAM1: Gateway to the Aging Brain?

CONFERENCE COVERAGE 2018-07-17 Conference Coverage Remember those eerie research findings evoking “The Twilight Zone”? Mysterious ingredients in the blood of young mice rejuvenated the brains of their elders, while the blood of old mice sped up aging in young’uns. The identity of blood ...

Synaptic Tau Clangs the Dinner Bell for Hungry Microglia

CONFERENCE COVERAGE 2018-07-17 Conference Coverage When tau strays into neuronal synapses, microglia see food. That is one possible interpretation from a handful of presentations at the joint Keystone symposia—Advances in Neurodegenerative Disease Research and Therapy / New Frontiers ...

TREM2: Diehard Microglial Supporter, Consequences Be DAMed

CONFERENCE COVERAGE 2018-07-13 Conference Coverage Like a dedicated mother doling out heaps of unconditional love, TREM2 supports microglial cells in all their pursuits, whether they help or hurt the brain. Trash clean-up, Aβ plaque containment, calling in blood cells for reinforcement ...

A Delicate Frontier: Human Microglia Focus of Attention at Keystone

CONFERENCE COVERAGE 2018-07-13 Conference Coverage For a pesky cell type that comprises a small fraction of cells in the brain, microglia have an outsize impact on neurodegeneration. Many of the Alzheimer’s risk loci identified in genome-wide association studies harbor genes expressed ...

NIH Summit Wraps Up with Recommendations for Research

CONFERENCE COVERAGE 2018-06-01 Conference Coverage The third summit on AD since 2012, called NIH Alzheimer's Research Summit 2018: Path to Treatment and Prevention, was scheduled for March 1 and 2 at the institute's Bethesda campus in Maryland. Day one went off without a ...

At AAN, Sights Set on Antisense Therapies for Diseases of the Brain

CONFERENCE COVERAGE 2018-05-25 Conference Coverage In recent years, two antisense oligonucleotide therapies have hit the market, at least nine more are in clinical trials for the treatment of neurologic diseases, and nearly two dozen are in preclinical testing, including ASOs for ...

As RNA Therapies Come of Age, Efficacy Remains Weak

CONFERENCE COVERAGE 2018-05-25 Conference Coverage Recent approvals of antisense therapies for spinal muscular atrophy and Duchenne muscular dystrophy have bolstered hopes for targeting RNA to treat a plethora of neurodegenerative brain disorders. At the 70th annual meeting of the ...

New Alzheimer’s and Parkinson’s Immunotherapy Data at AAN

CONFERENCE COVERAGE 2018-05-04 Conference Coverage For neurodegeneration researchers, highlights at the 2018 conference of the American Academy of Neurology, held April 21–27 in Los Angeles, California, were centiloid analysis of PET scans, the latest cognition update from people ...

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