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Technology for Patients: Purring Robots, Digital Data-Gathering

CONFERENCE COVERAGE 2018-08-29 Conference Coverage As technology becomes ever more part of modern life, researchers are exploring how it can help people with dementia. At a satellite conference held July 21 in Chicago, before the Alzheimer’s Association International Conference, ...

For the Faint of Heart: Doc, Want to Check Their NfL?

CONFERENCE COVERAGE 2018-08-28 Conference Coverage Part 2 of 2. Click here for Part 1. With interest blooming in blood NfL as an easily accessed marker of neurodegeneration, disease severity, and prognosis (see Part 1 of this story),  researchers are looking for practical applications. ...

Blood Test for Neurofilament Light Chain Kicks Up Biomarker Research

CONFERENCE COVERAGE 2018-08-28 Conference Coverage Part 1 of 2. Click here for Part 2. When axons in the brain’s white matter start to fall apart—be it from insult or injury—they release the protein neurofilament light chain. Thus dumped, NfL finds its way into the cerebrospinal fluid ...

Brain Damage from Cardiovascular Disease Starts Earlier Than You Think

CONFERENCE COVERAGE 2018-08-24 Conference Coverage Scientists agree that midlife cardiovascular risk factors portend late-life dementia. But exactly when in midlife? Two separate, but complementary, studies presented at this year’s Alzheimer’s Association International Conference, held ...

With Sudden Progress, Blood Aβ Rivals PET at Detecting Amyloid

CONFERENCE COVERAGE 2018-08-24 Conference Coverage A lot can happen in a year. At the 2017 Alzheimer’s Association International Conference in London, Randall Bateman ’s team at Washington University in St. Louis wowed the crowd with a blood assay for Aβ that predicted brain amyloid ...

Estrogen’s Benefit Tied to Age: Good for the Young, Bad for the Old

CONFERENCE COVERAGE 2018-08-23 Conference Coverage Part 2 of 2. Click here for Part 1.  The story of estrogen and Alzheimer’s disease is one of controversy. Epidemiological studies consistently suggest the hormone protects the brain, but the landmark Women’s Health Initiative Memory ...

Do Brain Changes at Menopause Make Women More Prone to Alzheimer’s?

CONFERENCE COVERAGE 2018-08-23 Conference Coverage Part 1 of 2. Click here for Part 2. More women have Alzheimer’s than men—but why? At the Alzheimer’s Association International Conference, held July 22–26 in Chicago, speakers agreed that it is not simply because women live longer, but ...

Weeklong Chinese Challenge Reveals Subtle Memory Problems

CONFERENCE COVERAGE 2018-08-23 Conference Coverage Could learning Chinese make a game out of cognitive testing—all the while spotting earlier stages of decline within a week’s time? Perhaps, according to work presented at the Alzheimer’s Association International Conference, held July ...

Surprise: HDAC Goes Down, Not Up, in Alzheimer’s Disease

CONFERENCE COVERAGE 2018-08-18 Conference Coverage As gene regulation changes in Alzheimer’s disease, scientists believe that histone deacetylases (HDACs) go into overdrive, shutting down transcription of certain genes. Consequently, several research groups are exploring the potential ...

Memory Slips as Soon as Amyloid Appears, Two Decades Before Dementia

CONFERENCE COVERAGE 2018-08-17 Conference Coverage How early in Alzheimer’s disease does a person’s memory falter? As soon as amyloid starts to build up, according to speakers at the Alzheimer’s Association International Conference in Chicago July 22–26. Even before an amyloid scan ...

Four Immunotherapies Now Banish Amyloid From the Brain

CONFERENCE COVERAGE 2018-08-17 Conference Coverage After years of fits and starts, anti-amyloid immunotherapies are finally hitting their target effectively. At least four drugs have now demonstrated the ability to clear plaques from the brain: aducanumab, gantenerumab, Lilly’s ...

Could Better Blood Pressure Management Preserve Cognition?

CONFERENCE COVERAGE 2018-08-03 Conference Coverage Is 120 the new 140…for systolic blood pressure, that is? The penultimate day of the Alzheimer's Association International Conference 2018, which ran July 20–26 in Chicago, brought some good news on prevention. Researchers reported ...

PET Ligand Lights Up AAIC, May Detect Synapse Loss in AD

CONFERENCE COVERAGE 2018-08-03 Conference Coverage Among Alzheimer’s disease pathologies, synaptic loss correlates best with symptoms, but until now researchers have had no way to measure it in living people. That may be changing, with a new PET ligand that binds synaptic vesicle ...

On Target: Crenezumab Reduces Aβ Oligomers in CSF

CONFERENCE COVERAGE 2018-07-31 Conference Coverage An anti-amyloid antibody reduces levels of Aβ oligomers in the cerebrospinal fluid of most patients tested, according to late-breaking results presented at the Alzheimer’s Association International Conference in Chicago on July 25. In ...

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