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Brain Conference Spotlights Transcriptomics, Therapeutic Strategies

CONFERENCE COVERAGE 2019-05-24 Conference Coverage About 140 scientists gathered in Rungstedgaard, north of Copenhagen, Denmark, May 5–9 for the biannual Brain Conference organized by the Federation of European Neuroscience Societies and the Lundbeck Foundation. Co-chaired by Beth ...

Antisense Oligonucleotides: Can They Take on ALS, SMA, Prions?

CONFERENCE COVERAGE 2019-05-22 Conference Coverage At the American Academy of Neurology’s 71st Annual Meeting, held May 4–10 in Philadelphia, researchers showcased their latest data on antisense oligonucleotides (ASOs). These short, synthetic, single-stranded oligodeoxynucleotides bind ...

BACE Inhibitors: Postmortem on One, Live Updates on Two

CONFERENCE COVERAGE 2019-05-17 Conference Coverage At the AD/PD 2019 conference held recently in Lisbon, the amyloid hypothesis was reeling from repeated gut punches in the clinic. Both antibodies and BACE inhibitors are facing relentless criticism from academic scientists and ...

Keep Your Enthusiasm? Scientists Process Brutal Trial Data

CONFERENCE COVERAGE 2019-05-16 Conference Coverage “There is a lot of bad news, but it’s useful bad news.” This line by Randy Bateman of Washington University, St. Louis, captured the mood at the AD/PD conference held March 27 to 31 in Lisbon, Portugal. Whereas in years past scientists ...

Forget Fibrils: Lewy Pathology Is More Lipid Than Protein

CONFERENCE COVERAGE 2019-05-10 Conference Coverage In Parkinson’s disease, abnormal deposits called Lewy bodies and Lewy neurites pop up in neurons and processes, respectively. In 1998, Maria Grazia Spillantini at the University of Cambridge identified α-synuclein as their major ...

Do Immune Cells Promote the Spread of α-Synuclein Pathology?

CONFERENCE COVERAGE 2019-05-10 Conference Coverage How does α-synuclein pathology spread? At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 27–31 in Lisbon, Portugal, speakers said immune cells bear some of the blame. Markus Britschgi of Roche in ...

Antibodies Against Microglial Receptors TREM2 and CD33 Head to Trials

CONFERENCE COVERAGE 2019-05-10 Conference Coverage As neuroinflammation becomes ever more deeply implicated in Alzheimer’s disease, therapies targeting this process are starting to enter clinical trials. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held ...

Drug Reported to Help Alzheimer’s Patients Sleep Better

CONFERENCE COVERAGE 2019-05-10 Conference Coverage Nearly half of people with Alzheimer’s can’t sleep at night, waking up more often and staying awake longer than others their age. This causes nighttime wandering, and worsens cognition and depression. Despite the burden for both ...

Off-Balance Endocytosis Lays Groundwork for Disease

CONFERENCE COVERAGE 2019-05-03 Conference Coverage Endocytosis is implicated in Alzheimer’s pathogenesis, because the continuous swallowing up of proteins from the cell surface and packaging them into little organelles brings the amyloid precursor protein (APP) into contact with the ...

On The Docket at AD/PD: The Many Crimes of ApoE4

CONFERENCE COVERAGE 2019-05-01 Conference Coverage Despite years of study, ApoE still has secrets to give up. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 27–31 in Lisbon, Portugal, researchers indicted ApoE4 on several fronts. They charged ...

ARIAS: Zooming in On Eye-based Biomarkers for Alzheimer’s

CONFERENCE COVERAGE 2019-04-30 Conference Coverage Have biomarkers for preclinical Alzheimer’s disease been staring us in the face all along, and we just did not see them? Recent studies report a plethora of changes in the eye as Aβ pathology emerges in the brain. Dwindling retinal ...

Spitting, Sniffing: Is This How We Will Dx Parkinson’s?

CONFERENCE COVERAGE 2019-04-30 Conference Coverage The quest for a noninvasive diagnostic test is leading Parkinson’s scientists to unlikely places. One is inside the mouth. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases in Lisbon, Portugal, Giorgio ...

Chimeric Mice: Can They Model Human Microglial Responses?

CONFERENCE COVERAGE 2019-04-26 Conference Coverage Microglia are finicky. Take them out of their normal environment and they have a personality meltdown. They dramatically change gene expression and just about turn into a different type of cell. How, then, to study human microglia in a ...

Could Greasing the Wheels of Lipid Processing Treat Alzheimer’s?

CONFERENCE COVERAGE 2019-04-24 Conference Coverage ApoE4 impairs how the brain handles lipids. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 27–31 in Lisbon, Portugal, researchers argued that this effect of AD’s biggest risk gene is important ...

Could CD33 Be the Microglial Target for Stimulating Phagocytosis?

CONFERENCE COVERAGE 2019-04-23 Conference Coverage Much of the research on microglia in Alzheimer’s disease has focused on the TREM2 receptor (see Part 4 of this series). But other microglial receptors play a hand in age- and injury-related activation as well (e.g.,  Apr 2019 news on ...

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