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Field Loses Beloved Wizard of Glia, Ben Barres, 63

CONFERENCE COVERAGE 2018-01-04 Conference Coverage Alzheimer’s researchers, and colleagues across neuroscience, are mourning the loss of Ben Barres, who died December 27 of pancreatic cancer at the age of 63. First diagnosed in March 2016, Barres continued pursuing the work he loved ...

Is There No End to Tau’s Toxic Tricks?

CONFERENCE COVERAGE 2017-12-28 Conference Coverage Besides the protein aggregates that mark tauopathies, in turns out that mutant forms of tau damage neurons in myriad other ways. Many were scrutinized at the Society for Neuroscience conference, held November 11–15 in Washington, D.C. ...

Gut Microbiome May Modify Neurodegeneration

CONFERENCE COVERAGE 2017-12-22 Conference Coverage At the Society for Neuroscience annual meeting, held November 11–15 in Washington, D.C., scientists presented further hints that bacteria in the gut may influence the symptoms and pathology of Alzheimer’s and other neurodegenerative ...

Disturbed Sleep Exerts Toll on Memory and Neurodegeneration

CONFERENCE COVERAGE 2017-12-22 Conference Coverage The indispensable role of a good night’s sleep in memory and brain health was the subject of several talks at the Society for Neuroscience annual meeting, held November 11–15 in Washington, D.C. How might sleep-driven memory processes ...

Tau Snapshots from Neuroscience 2017

CONFERENCE COVERAGE 2017-12-22 Conference Coverage This year’s Society for Neuroscience meeting, held November 11–15 in Washington, D.C., drew 23,526 attendees from around the globe. For researchers in the Alzheimer’s disease field, the meeting has lost some of its vibrancy of late, ...

At Least We Know These Don’t Work: Negative Trials at CTAD

CONFERENCE COVERAGE 2017-12-15 Conference Coverage Confirming once again that not only anti-amyloid therapeutic approaches struggle to score a win in Alzheimer’s and related dementias, the 10th CTAD conference, held November 1–4 in Boston, featured rest-in-peace presentations on a ...

In the Running: Trial Results from CTAD Conference

CONFERENCE COVERAGE 2017-12-15 Conference Coverage Researchers presented a fall crop of Phase 1 results at the recent Clinical Trials in Alzheimer’s Disease meeting, held November 1–4 in Boston. New treatments aimed at neurotrophin signaling, tau, and cholinergic pathways moved on to ...

Blood, the Secret Sauce? Focus on Plasma Promises AD Treatment

CONFERENCE COVERAGE 2017-12-14 Conference Coverage In mice, infusing young blood rejuvenates the old, and even staves off some of the changes linked to Alzheimer’s. It’s too early to say if the same is true in people, but first results look encouraging. At the 2017 Clinical Trials on ...

Pimavanserin Trial Raises Hope for Treating Dementia-Related Psychosis

CONFERENCE COVERAGE 2017-12-13 Conference Coverage Advancing dementia can bring with it psychosis, which greatly adds to the burden of life with Alzheimer’s disease for both the sufferer and his or her carers. No drugs are approved to treat dementia-related psychosis. Used off-label, ...

High-Dose Gantenerumab Lowers Plaque Load

CONFERENCE COVERAGE 2017-12-13 Conference Coverage At this year’s Clinical Trials on Amyloid Disease meeting, held November 1–4 in Boston, Roche scientists showed that high doses of gantenerumab  reduced amyloid plaques in the brains of people with Alzheimer’s disease, and that raising ...

Verubecestat Negative Trial Data: What Does it Mean for BACE Inhibition?

CONFERENCE COVERAGE 2017-12-12 Conference Coverage The room was packed at the recent Clinical Trials on Alzheimer’s Disease conference, when Mike Egan of Merck & Co. presented much-anticipated data of EPOCH, the first efficacy trial of his company’s BACE inhibitor verubecestat. An ...

Don’t Be an Enrollment Loser: Throw Your Own Swab-a-Palooza!

CONFERENCE COVERAGE 2017-12-12 Conference Coverage The enormous challenges of recruitment loomed large at the 10th annual Clinical Trials on Amyloid Disease conference, held November 1–4 in Boston. Researchers are seeking new ways of identifying legions of eligible volunteers to enroll ...

Cognitive Testing Is Getting Faster and Better

CONFERENCE COVERAGE 2017-12-09 Conference Coverage If Jason Hassenstab has his way, an app that pings trial participants to take quick cognitive tests on their own cell phones will boost the reliability of data in future prevention studies. Hassenstab works at Washington University, St ...

Automated CSF Tests: Check. Blood Tests: In the Works

CONFERENCE COVERAGE 2017-12-08 Conference Coverage As prevention trials for Alzheimer’s disease ramp up, researchers need fast and cheap ways to diagnose early, and to screen cognitively normal people. PET is expensive. Cerebrospinal fluid (CSF) biomarkers of amyloidosis and tauopathy ...

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