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Move Over CSF, P-Tau in Blood Also Tells Us There’s Plaque in the Brain

CONFERENCE COVERAGE 2019-08-20 Conference Coverage From day one at this year’s AAIC, held July 14-18 in Los Angeles, conference halls and corridors buzzed with the sound of “p-tau.” Scientists from Randall Bateman ’s lab at Washington University, St. Louis, reported that among ...

Move Over Aβ, CSF P-Tau Tells Us There’s Plaque in the Brain

CONFERENCE COVERAGE 2019-08-20 Conference Coverage Just as labs around the globe are racing to start marketing plasma Aβ tests, along come new contenders to rattle the field. At this year’s AAIC, held July 14-18 in Los Angeles, scientists reported that certain amino acids on the ...

Geneticists Seek Out Rare Contributors to Alzheimer’s

CONFERENCE COVERAGE 2019-08-15 Conference Coverage At one end of the Alzheimer’s disease genetic spectrum lie the catastrophic mutations in APP and presenilin that lead to autosomal-dominant, early onset AD. At the other end are dozens of common variants that each contribute a smidgen ...

Rare Luck: Two Copies of ApoE2 Shield Against Alzheimer’s

CONFERENCE COVERAGE 2019-08-08 Conference Coverage Mention ApoE and Alzheimer’s, and the conversation turns to the E4 allele, the strongest susceptibility gene for the disease. But ApoE has another side, in ApoE2. Though this isoform protects against AD, scientists have barely studied ...

Colombian Cohort Delivers Data on Blood NfL

CONFERENCE COVERAGE 2019-08-08 Conference Coverage At the Alzheimer’s Association International Conference, held July 14–18 in Los Angeles, a blood test indicating that neurons in the brain are degenerating generated considerable buzz. Eric Reiman, Banner Alzheimer’s Institute, Phoenix ...

Crenezumab Update: Baseline Data from Colombian Prevention Trial

CONFERENCE COVERAGE 2019-08-08 Conference Coverage A subset of the world’s largest known kindred of autosomal-dominant Alzheimer’s disease, near the Colombian city of Medellin, have enrolled in the Banner Alzheimer Prevention Initiative Autosomal Dominant Alzheimer’s Disease trial. It ...

ASOs: Wave of the Future in Alzheimer’s Therapeutics?

CONFERENCE COVERAGE 2019-08-02 Conference Coverage When participants in the Dominantly Inherited Alzheimer’s Network (DIAN) met in Los Angeles on July 13, they heard from their at-risk fellow travelers (see Part 1 of this series), learned how their tissue donations continue to advance ...

Genetics Propels DIAN Toward Therapies

CONFERENCE COVERAGE 2019-08-02 Conference Coverage Each year, the DIAD family conference held in advance of the Alzheimer's Association International Conference features a science update, and this year the focus was on genetics. DIAN families know that the modern era of Alzheimer ...

DIAD: Families from Argentina, Canada, Minnesota Rally a Global Community

CONFERENCE COVERAGE 2019-08-02 Conference Coverage “One day you will tell your story of how you’ve overcome what you are going through now, and it will become part of someone else’s survival guide.” Luciana, 29, DIAN participant. “The disease might lie inside us, but so does the cure.” ...

Physical Activity May Shield the Brain from the Onslaught of Aβ

CONFERENCE COVERAGE 2019-07-25 Conference Coverage Physical activity not only benefits the heart and the body, it may also shield the brain from the damaging effects of Aβ. That’s according to findings presented at the Alzheimer’s Association International Conference, held July 14–18 ...

New PET Staging Scheme for Amyloid?

CONFERENCE COVERAGE 2019-07-25 Conference Coverage Scientists are becoming more nuanced in how they use amyloid scans—not just to detect the presence of Alzheimer’s pathology, but also to pinpoint disease stage. At this year’s Alzheimer’s Association International Conference, held July ...

Can Researchers Detect Dementia With Lewy Bodies at the Prodromal Stage?

CONFERENCE COVERAGE 2019-07-21 Conference Coverage For neurodegenerative disease, the mantra is “go early,” based on the theory that intervention at prodromal stages may be most effective. Early detection could also help patients and families plan for the future, and avoid drugs ...

Consortia Assemble Worldwide to Take on Lewy Body Dementia

CONFERENCE COVERAGE 2019-07-20 Conference Coverage Research into dementia with Lewy bodies has lagged behind that for Alzheimer’s and Parkinson’s diseases, in part because DLB is difficult to identify, and less common. Many DLB trials fold because enrollment goals cannot be met. To ...

New Tool Kit Helps Physicians Recognize and Manage Lewy Body Dementias

CONFERENCE COVERAGE 2019-07-19 Conference Coverage Lewy body dementia, the second-most-common progressive dementia after Alzheimer’s disease, receives relatively little attention and few research dollars, and often goes undiagnosed. Comedian Robin Williams, perhaps the most famous ...

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