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Chris Dobson, Master of Protein Folding Research, Dies at 69

COMMUNITY NEWS 2019-09-17 Community News Researchers are mourning the passing of a giant in the field of protein chemistry. Christopher Dobson succumbed to cancer on September 8, a month shy of his 70th birthday. Dobson, who had worked at the University of Cambridge since 2001, ...

Newly Identified Microglia Contain Lipid Droplets, Harm Brain

RESEARCH NEWS 2019-08-23 Research News Microglia in the brain assume a dizzying array of states. Now researchers led by Tony Wyss-Coray at Stanford University, Palo Alto, California, describe a new one: lipid droplet-accumulating microglia (LAM). These lipid-stuffed cells ...

In Alzheimer’s, More TREM2 Is Good for You

RESEARCH NEWS 2019-08-29 Research News Certain mutations in TREM2 strongly increase risk for late-onset Alzheimer’s. Could tweaking the function of this microglial receptor help people with the disease? A new study suggests as much. In the August 28 Science Translational Medicine ...

Blood Pressure: How Low to Prevent Dementia—and When?

RESEARCH NEWS 2019-08-23 Research News Mounting evidence suggests midlife hypertension negatively affects late-life cognition and that treating it could help. Three new papers support this idea. In the August 20 Lancet, researchers led by Marcus Richards, Nick Fox, and Jonathan ...

Spatial Transcriptomics Uncovers Coordinated Cell Responses to Amyloid

RESEARCH NEWS 2019-08-23 Research News With single-cell resolution, scientists now have a good idea of what amyloid plaques do to nearby cells in the brains of mice. Scientists led by Bart De Strooper, KU Leuven, Belgium, used a combination of spatial transcriptomics and in situ ...

Islands of Tau Coat and Protect Cytoskeleton

RESEARCH NEWS 2019-09-06 Research News Two papers in the September 2 Nature Cell Biology present complementary evidence that tau condenses into a patchwork of rafts that coat microtubules. These patches share some properties with phase-separated liquid droplets of tau that have ...

Are Microglia Plaque Factories?

RESEARCH NEWS 2019-09-04 Research News Are microglia the masterminds of amyloid plaque formation? In the August 21 Nature Communications, researchers led by Kim Green at the University of California, Irvine, suggest these cells seed amyloid deposits. In a mouse model of ...

Hello Mitochondriomics: Tagging Method Identifies Different Subtypes

RESEARCH NEWS 2019-09-11 Research News Mitochondria may be the universal powerhouses of eukaryotic cells, but there is more to these organelles than just ATP production. According to a paper in the September 9 Nature Neuroscience, mouse mitochondria express distinct subsets of ...

Tiny Brain Structure Plays Big Role in Memory

RESEARCH NEWS 2019-09-13 Research News The humble locus coeruleus, a minute speck of tissue nestled deep in the brain stem, has received relatively scant attention in studies of cognitive decline. Now, data published September 9 in Nature Human Behavior add to a recent spate of ...

Among AD Mutations, Only ApoE4 Seems to Hobble Microglia

RESEARCH NEWS 2019-09-14 Research News New research adds to the evidence that ApoE regulates microglial health and activity. Researchers led by Tarja Malm at the University of Eastern Finland, Kuopio, examined how several Alzheimer’s risk factors affect microglia generated from ...

PET Identifies Tangles Decades after a Single Traumatic Brain Injury

RESEARCH NEWS 2019-09-07 Research News Traumatic brain injuries trigger tau pathology and raise the risk of developing dementia later in life. Could tau PET tracers help researchers pick out those on the path to neurodegeneration? Yes, according to a paper in the September 4 ...

In Mice and Men, Prostate Drug Reportedly Treats Parkinson’s Disease

RESEARCH NEWS 2019-09-20 Research News A drug commonly prescribed to keep enlarged prostates in check may hold promise for Parkinson’s disease. According to a study published September 16 in the Journal of Clinical Investigation, terazosin (TZ), an α1-adrenergic receptor ...

Synaptic Proteins in CSF: New Markers of Cognitive Decline?

CONFERENCE COVERAGE 2019-08-22 Conference Coverage Plasma tests for Aβ and phospho-tau may have stolen the show at this year’s Alzheimer’s Association International Conference, held July 14-18 in Los Angeles, but proteomic and synaptic markers were not that far behind. A neural ...

Proteomics Uncovers Potential Markers, Subtypes of Alzheimer’s

CONFERENCE COVERAGE 2019-08-22 Conference Coverage In the last three decades, scientists have made strides in using biomarkers to diagnose Alzheimer’s disease and track its progression. Along with cerebrospinal fluid Aβ, tau, and phospho-tau, a handful of new markers, such as ...

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