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Familial AD Mutations, β-CTF, Spell Trouble for Endosomes

RESEARCH NEWS 2019-08-19 Research News Faltering endosomal trafficking appears to be the common modus operandi by a range of familial Alzheimer’s mutations. In the August 14 Neuron, researchers led by Marc Tessier-Lavigne of Stanford University reported initial findings from a ...

Colleagues Mourn Loss of Rahul Desikan, Age 41, to ALS

COMMUNITY NEWS 2019-08-08 Community News Neuroscientists are mourning the loss of a beloved colleague and innovator. At the age of 41, Rahul Desikan died of amyotrophic lateral sclerosis (ALS)—a devastating neurodegenerative disease that he studied. Despite being struck with an ...

Chris Dobson, Master of Protein Folding Research, Dies at 69

COMMUNITY NEWS 2019-09-17 Community News Researchers are mourning the passing of a giant in the field of protein chemistry. Christopher Dobson succumbed to cancer on September 8, a month shy of his 70th birthday. Dobson, who had worked at the University of Cambridge since 2001, ...

Anatomy News Flash: Brain Drains Lymphatic Fluid Through Its Base

RESEARCH NEWS 2019-07-26 Research News The 2015 discovery of lymphatic vessels in the brain’s meninges threw open a door to seeing how this still-mysterious organ clears waste. Subsequent work showed that these vessels, which reside in the brain’s outermost membrane, the dura ...

AbbVie’s Tau Antibody Flops in Progressive Supranuclear Palsy

RESEARCH NEWS 2019-07-26 Research News According to an industry report today, AbbVie has called a halt to the Phase 2 trial of its anti-tau antibody ABBV-8E12 for progressive supranuclear palsy after it failed a futility analysis. AbbVie announced the termination during a ...

New PET Staging Scheme for Amyloid?

CONFERENCE COVERAGE 2019-07-25 Conference Coverage Scientists are becoming more nuanced in how they use amyloid scans—not just to detect the presence of Alzheimer’s pathology, but also to pinpoint disease stage. At this year’s Alzheimer’s Association International Conference, held July ...

Cognitive Decline Trips Up API Trials of BACE Inhibitor

RESEARCH NEWS 2019-07-12 Research News The Alzheimer’s field was dealt another body blow yesterday with the announcement of a premature end to testing of Novartis/Amgen’s BACE inhibitor CNP520, aka umibecestat, in two Phase 2/3 trials. Part of the Alzheimer’s Prevention ...

AD Genetic Risk Tied to Changes in Microglial Gene Expression

RESEARCH NEWS 2019-08-09 Research News Geneticists have found dozens of loci that associate with Alzheimer’s disease, but the functional variants and even the genes that underlie these associations often remain elusive. Now, researchers led by Alison Goate and Edoardo Marcora at ...

Newly Identified Microglia Contain Lipid Droplets, Harm Brain

RESEARCH NEWS 2019-08-23 Research News Microglia in the brain assume a dizzying array of states. Now researchers led by Tony Wyss-Coray at Stanford University, Palo Alto, California, describe a new one: lipid droplet-accumulating microglia (LAM). These lipid-stuffed cells ...

In Alzheimer’s, More TREM2 Is Good for You

RESEARCH NEWS 2019-08-29 Research News Certain mutations in TREM2 strongly increase risk for late-onset Alzheimer’s. Could tweaking the function of this microglial receptor help people with the disease? A new study suggests as much. In the August 28 Science Translational Medicine ...

Blood Pressure: How Low to Prevent Dementia—and When?

RESEARCH NEWS 2019-08-23 Research News Mounting evidence suggests midlife hypertension negatively affects late-life cognition and that treating it could help. Three new papers support this idea. In the August 20 Lancet, researchers led by Marcus Richards, Nick Fox, and Jonathan ...

Aβ Dimers Block Glutamate Uptake, Fire Up Synapses

RESEARCH NEWS 2019-08-09 Research News Soluble Aβ sends neurons into a hyperactive frenzy, but scientists don’t know why. New evidence suggests that the peptide causes the excitatory neurotransmitter glutamate to build up in synapses, making neurons hyperactive. In the August 9 ...

ApoE4 Glia Bungle Lipid Processing, Mess with the Matrisome

RESEARCH NEWS 2019-08-16 Research News ApoE4 predisposes people to Alzheimer’s disease by modulating astrocytes and microglia, suggest researchers led by Julia TCW and Alison Goate at the Icahn School of Medicine at Mount Sinai, New York. In a preprint on bioRχiv, the researchers ...

Spatial Transcriptomics Uncovers Coordinated Cell Responses to Amyloid

RESEARCH NEWS 2019-08-23 Research News With single-cell resolution, scientists now have a good idea of what amyloid plaques do to nearby cells in the brains of mice. Scientists led by Bart De Strooper, KU Leuven, Belgium, used a combination of spatial transcriptomics and in situ ...

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