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Biogen/Eisai Halt Phase 3 Aducanumab Trials

RESEARCH NEWS 2019-03-21 Research News Today, Biogen and Eisai announced they would terminate the Phase 3 ENGAGE and EMERGE trials of aducanumab for early Alzheimer’s disease. A futility analysis run by an independent data-monitoring committee concluded that that trials would not ...

When Host Proteins Coat Virus, Amyloid Fibrils Form

RESEARCH NEWS 2019-05-29 Research News When a virus enters a biological fluid of a host—blood, lung, or cerebrospinal fluid—it becomes ensheathed by a unique set of proteins from its new environment. The proteins that make up the sheath differ depending on the fluid and on the ...

Closing the Book on NSAIDs for Alzheimer’s Prevention

RESEARCH NEWS 2019-04-12 Research News Epidemiological data suggest that non-steroidal anti-inflammatory drugs (NSAIDs) stave off dementia, but multiple clinical trials have failed to bear that out. Now, the most recent and, the authors say, final effort has come up short. In the ...

Introducing LATE—A Common TDP-43 Proteinopathy that Strikes After 80

RESEARCH NEWS 2019-05-01 Research News An 86-year-old woman develops classic amnestic symptoms of Alzheimer’s disease in her last years of life, but upon autopsy, her brain bears but a modest burden of Aβ plaques and tau tangles. Instead, TDP-43 inclusions crowd her limbic ...

Do Tribes of Astrocytes Wage War on Synapses?

RESEARCH NEWS 2019-04-05 Research News As researchers are becoming wise to microglial diversity, they may also want to keep their eyes out for varied populations of the true glia of the brain. In the April 1 Nature Neuroscience, Jeffrey Rothstein’s group at Johns Hopkins ...

ARIAS: Zooming in On Eye-based Biomarkers for Alzheimer’s

CONFERENCE COVERAGE 2019-04-30 Conference Coverage Have biomarkers for preclinical Alzheimer’s disease been staring us in the face all along, and we just did not see them? Recent studies report a plethora of changes in the eye as Aβ pathology emerges in the brain. Dwindling retinal ...

Cut Loose, Soluble TREM2 Beckons Microglia to Mop Up Plaques

RESEARCH NEWS 2019-04-05 Research News As if the biological functions of membrane-bound TREM2 weren’t complicated enough, researchers also have to contend with the actions of its freewheeling counterpart, soluble TREM2. In the March 25 Nature Communications, researchers led by ...

Unequal: Some Tau Haplotypes Carry More Risk Than Others

RESEARCH NEWS 2019-03-22 Research News Scientists have known for years that the common H1 haplotype of the tau gene MAPT somehow raises a person’s risk of the rare neurodegenerative disorder progressive supranuclear palsy (PSP). It does so by more than fivefold, similar to what ...

Results from Verubecestat APECS Trial Published

RESEARCH NEWS 2019-04-11 Research News Results were published today from the APECS trial, a Phase 3 study of the BACE1 inhibitor verubecestat. In the April 11 New England Journal of Medicine, researchers led by Michael Egan, Merck, Kenilworth, New Jersey, reported that dementia ...

Plasma NfL Goes the Distance in Alzheimer’s

RESEARCH NEWS 2019-05-02 Research News Damaged axons spill their guts, and the debris eventually makes its way into the bloodstream. Now, scientists tracking one such neuron-derived protein are moving closer to a blood test for neurodegeneration in Alzheimer’s disease. In a ...

Plasticity Hums With Protein Synthesis on Both Sides of Synapse

RESEARCH NEWS 2019-05-17 Research News Scientists know that synaptic plasticity requires local protein production from translation of mRNAs in postsynaptic dendrites. However, local synthesis had not been clearly demonstrated on the other, presynaptic side in mature axons. A new ...

The Mutation You Want: It Protects the Brain, Extends Life

RESEARCH NEWS 2019-05-31 Research News The lucky carriers of a coding variant in the phospholipase Cγ2 (PLCG2) gene may reap even more benefits than previously thought. In the May 27 Acta Neuropathologica, researchers confirm that people with the rs72824905-G allele not only ...

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