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Biogen/Eisai Halt Phase 3 Aducanumab Trials

RESEARCH NEWS 2019-03-21 Research News Today, Biogen and Eisai announced they would terminate the Phase 3 ENGAGE and EMERGE trials of aducanumab for early Alzheimer’s disease. A futility analysis run by an independent data-monitoring committee concluded that that trials would not ...

Familial AD Mutations, β-CTF, Spell Trouble for Endosomes

RESEARCH NEWS 2019-08-19 Research News Faltering endosomal trafficking appears to be the common modus operandi by a range of familial Alzheimer’s mutations. In the August 14 Neuron, researchers led by Marc Tessier-Lavigne of Stanford University reported initial findings from a ...

Colleagues Mourn Loss of Rahul Desikan, Age 41, to ALS

COMMUNITY NEWS 2019-08-08 Community News Neuroscientists are mourning the loss of a beloved colleague and innovator. At the age of 41, Rahul Desikan died of amyotrophic lateral sclerosis (ALS)—a devastating neurodegenerative disease that he studied. Despite being struck with an ...

Chris Dobson, Master of Protein Folding Research, Dies at 69

COMMUNITY NEWS 2019-09-17 Community News Researchers are mourning the passing of a giant in the field of protein chemistry. Christopher Dobson succumbed to cancer on September 8, a month shy of his 70th birthday. Dobson, who had worked at the University of Cambridge since 2001, ...

When Host Proteins Coat Virus, Amyloid Fibrils Form

RESEARCH NEWS 2019-05-29 Research News When a virus enters a biological fluid of a host—blood, lung, or cerebrospinal fluid—it becomes ensheathed by a unique set of proteins from its new environment. The proteins that make up the sheath differ depending on the fluid and on the ...

CryoEM γ-Secretase Structures Nail APP, Notch Binding

RESEARCH NEWS 2019-01-11 Research News Targeting the γ-secretase protease to prevent Alzheimer’s disease would require surgical precision to shut down Aβ42 production while allowing the non-pathogenic processing of amyloid precursor protein (APP) and other important substrates to ...

Closing the Book on NSAIDs for Alzheimer’s Prevention

RESEARCH NEWS 2019-04-12 Research News Epidemiological data suggest that non-steroidal anti-inflammatory drugs (NSAIDs) stave off dementia, but multiple clinical trials have failed to bear that out. Now, the most recent and, the authors say, final effort has come up short. In the ...

Anatomy News Flash: Brain Drains Lymphatic Fluid Through Its Base

RESEARCH NEWS 2019-07-26 Research News The 2015 discovery of lymphatic vessels in the brain’s meninges threw open a door to seeing how this still-mysterious organ clears waste. Subsequent work showed that these vessels, which reside in the brain’s outermost membrane, the dura ...

ApoE Binds Complement Protein, Keeps Inflammatory Cascade in Check

RESEARCH NEWS 2019-02-01 Research News This story was updated on February 5, 2019. Just when you thought ApoE biology couldn’t get any more complicated, scientists have discovered a new function for this apolipoprotein. According to a January 28 paper in Nature Medicine, ApoE ...

BACE and γ-Secretase Form Mega-Complex that Processes APP

RESEARCH NEWS 2019-01-23 Research News The production of Aβ peptides from the amyloid precursor protein is a two-step affair: A first cut by the β-secretase (BACE) releases the extracellular portion of APP, leaving the C-terminal fragment (CTF) to find its way to γ-secretase for ...

Introducing LATE—A Common TDP-43 Proteinopathy that Strikes After 80

RESEARCH NEWS 2019-05-01 Research News An 86-year-old woman develops classic amnestic symptoms of Alzheimer’s disease in her last years of life, but upon autopsy, her brain bears but a modest burden of Aβ plaques and tau tangles. Instead, TDP-43 inclusions crowd her limbic ...

Dementia Researchers Commend FDA Crackdown on Supplement Hype

COMMUNITY NEWS 2019-03-10 Community News Purported miracle medicines have always been with us. In the 1800s, traveling salesmen hawked cure-all elixirs. Nowadays, companies peddle myriad supplements on the internet, often with spurious claims that they are “scientifically” proven ...

Sans Synuclein Tetramers, Mice Mimic Parkinson’s Disease

RESEARCH NEWS 2018-10-12 Research News A new model of Parkinson’s disease re-creates key features of the disorder, and helps steady one disputed theory of what causes it. Mice carrying mutations that disrupt physiological tetramers of the α-synuclein protein develop brain ...

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