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Biogen/Eisai Halt Phase 3 Aducanumab Trials

RESEARCH NEWS 2019-03-21 Research News Today, Biogen and Eisai announced they would terminate the Phase 3 ENGAGE and EMERGE trials of aducanumab for early Alzheimer’s disease. A futility analysis run by an independent data-monitoring committee concluded that that trials would not ...

BAN2401 Removes Brain Amyloid, Possibly Slows Cognitive Decline

CONFERENCE COVERAGE 2018-07-26 Conference Coverage The last full day of the Alzheimer's Association International Conference, which ended today in Chicago, saw scientists pack a room the size of an aircraft hangar in anticipation of a late addition to the scientific program. They ...

Herpes Triggers Amyloid—Could This Virus Fuel Alzheimer’s?

RESEARCH NEWS 2018-06-29 Research News Aβ is generally considered a rogue peptide, but recent research is building a case that it may have a secret identity as an antimicrobial superhero. Confronted with an unwelcome bacteria or fungus, the peptide quickly forms amyloid fibrils ...

When Host Proteins Coat Virus, Amyloid Fibrils Form

RESEARCH NEWS 2019-05-29 Research News When a virus enters a biological fluid of a host—blood, lung, or cerebrospinal fluid—it becomes ensheathed by a unique set of proteins from its new environment. The proteins that make up the sheath differ depending on the fluid and on the ...

CryoEM γ-Secretase Structures Nail APP, Notch Binding

RESEARCH NEWS 2019-01-11 Research News Targeting the γ-secretase protease to prevent Alzheimer’s disease would require surgical precision to shut down Aβ42 production while allowing the non-pathogenic processing of amyloid precursor protein (APP) and other important substrates to ...

Closing the Book on NSAIDs for Alzheimer’s Prevention

RESEARCH NEWS 2019-04-12 Research News Epidemiological data suggest that non-steroidal anti-inflammatory drugs (NSAIDs) stave off dementia, but multiple clinical trials have failed to bear that out. Now, the most recent and, the authors say, final effort has come up short. In the ...

Lymphatic Brain Drain Withers in Aging, Worsens Disease

RESEARCH NEWS 2018-07-27 Research News In recent years, scientists have characterized a hidden set of lymphatic vessels in the meninges, the membranes that line the skull and envelope the brain (Oct 2017 news). These meningeal lymphatic vessels carry waste from the cerebrospinal ...

ApoE Binds Complement Protein, Keeps Inflammatory Cascade in Check

RESEARCH NEWS 2019-02-01 Research News This story was updated on February 5, 2019. Just when you thought ApoE biology couldn’t get any more complicated, scientists have discovered a new function for this apolipoprotein. According to a January 28 paper in Nature Medicine, ApoE ...

Aberrant Networks in Alzheimer’s Tied to Herpes Viruses

RESEARCH NEWS 2018-06-21 Research News An extensive, multi-cohort, multi-network analysis of what goes wrong in the Alzheimer’s brain and why, has turned up none other than human herpes and other viruses. The big data analyses, a four-year project, is detailed in the June 21 ...

BACE and γ-Secretase Form Mega-Complex that Processes APP

RESEARCH NEWS 2019-01-23 Research News The production of Aβ peptides from the amyloid precursor protein is a two-step affair: A first cut by the β-secretase (BACE) releases the extracellular portion of APP, leaving the C-terminal fragment (CTF) to find its way to γ-secretase for ...

Dementia Researchers Commend FDA Crackdown on Supplement Hype

COMMUNITY NEWS 2019-03-10 Community News Purported miracle medicines have always been with us. In the 1800s, traveling salesmen hawked cure-all elixirs. Nowadays, companies peddle myriad supplements on the internet, often with spurious claims that they are “scientifically” proven ...

Introducing LATE—A Common TDP-43 Proteinopathy that Strikes After 80

RESEARCH NEWS 2019-05-01 Research News An 86-year-old woman develops classic amnestic symptoms of Alzheimer’s disease in her last years of life, but upon autopsy, her brain bears but a modest burden of Aβ plaques and tau tangles. Instead, TDP-43 inclusions crowd her limbic ...

In New ALS/FTD Mouse Model, Poly(GR) Peptides Poison Ribosomes

RESEARCH NEWS 2018-06-29 Research News As the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD), repeat expansions in the C9ORF72 gene spew a poisonous brew of abnormal RNAs and small dipeptide repeat (DPR) proteins. In a new mouse ...

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