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Invading T Cells Quash Neurogenesis

RESEARCH NEWS 2019-07-06 Research News Adult mammalian brains eke out limited numbers of new neurons in select regions, but over time, even that production dwindles. Why is unclear. New evidence from the lab of Anne Brunet, Stanford University, California, suggests invading ...

Epilogue on Edonerpic: It Does Not Work in Alzheimer’s

RESEARCH NEWS 2019-07-10 Research News The drug edonerpic maleate failed to slow cognitive decline in Alzheimer’s patients, according to a paper published online July 8 in JAMA Neurology. Scientists led by Lon Schneider, University of Southern California, Los Angeles, reported ...

Gently Used: Can Recycled Microglia Receptors Prevent Plaque?

RESEARCH NEWS 2019-06-28 Research News Microglia do much of the heavy lifting when it comes to removing Aβ, but how do they do it? Researchers led by Douglas Green, St. Jude Children’s Research Hospital, Memphis, Tennessee, have identified an endocytic recycling process by which ...

Deleting CD33 Benefits Mice—If Their Microglia Express TREM2

RESEARCH NEWS 2019-07-11 Research News From their perch on the microglial surface, CD33 and TREM2 exact opposing forces on microglial functions, including phagocytosis and inflammatory responses. Now, in a study published in Neuron on July 10, researchers led by Rudolph Tanzi at ...

In PD Model, α-Synuclein Spreads from Intestine to Brain

CONFERENCE COVERAGE 2019-07-12 Conference Coverage The hypothesis that Parkinson’s disease could arise within the belly, not the brain, now gains support with a new mouse model. Valina Dawson of Johns Hopkins University, Baltimore, reported at a joint symposium held June 16-21 in ...

Microglia Control Synapse Number in Multiple Disease States

CONFERENCE COVERAGE 2015-11-03 Conference Coverage What causes synapses to wither in neurodegenerative diseases such as Alzheimer’s? Some researchers blame reactivation of microglia, which prune unneeded synapses during brain development. At the Society for Neuroscience meeting held in ...

New Tool Kit Helps Physicians Recognize and Manage Lewy Body Dementias

CONFERENCE COVERAGE 2019-07-19 Conference Coverage Lewy body dementia, the second-most-common progressive dementia after Alzheimer’s disease, receives relatively little attention and few research dollars, and often goes undiagnosed. Comedian Robin Williams, perhaps the most famous ...

Can Researchers Detect Dementia With Lewy Bodies at the Prodromal Stage?

CONFERENCE COVERAGE 2019-07-21 Conference Coverage For neurodegenerative disease, the mantra is “go early,” based on the theory that intervention at prodromal stages may be most effective. Early detection could also help patients and families plan for the future, and avoid drugs ...

Consortia Assemble Worldwide to Take on Lewy Body Dementia

CONFERENCE COVERAGE 2019-07-20 Conference Coverage Research into dementia with Lewy bodies has lagged behind that for Alzheimer’s and Parkinson’s diseases, in part because DLB is difficult to identify, and less common. Many DLB trials fold because enrollment goals cannot be met. To ...

Don’t Be an Enrollment Loser: Throw Your Own Swab-a-Palooza!

CONFERENCE COVERAGE 2017-12-12 Conference Coverage The enormous challenges of recruitment loomed large at the 10th annual Clinical Trials on Amyloid Disease conference, held November 1–4 in Boston. Researchers are seeking new ways of identifying legions of eligible volunteers to enroll ...

Physical Activity May Shield the Brain from the Onslaught of Aβ

CONFERENCE COVERAGE 2019-07-25 Conference Coverage Physical activity not only benefits the heart and the body, it may also shield the brain from the damaging effects of Aβ. That’s according to findings presented at the Alzheimer’s Association International Conference, held July 14–18 ...

Ribosomal Protein Spurs Faulty Translation of Nucleotide Repeats

RESEARCH NEWS 2019-08-02 Research News A GGGGCC hexanucleotide repeat expansion in intron 1 of the C9ORF72 gene causes familial amyotrophic lateral sclerosis and frontotemporal dementia. Aberrant translation of this expansion results in toxic poly-dipeptides that build up in the ...

High and Low Hemoglobin Levels Tied to Alzheimer’s

RESEARCH NEWS 2019-08-02 Research News A study that followed more than 12,000 people for over 12 years adds significant weight to the idea that hemoglobin level is an important risk factor for Alzheimer’s and other dementias. Scientists led by M. Arfan Ikram at Erasmus Medical ...

ASOs: Wave of the Future in Alzheimer’s Therapeutics?

CONFERENCE COVERAGE 2019-08-02 Conference Coverage When participants in the Dominantly Inherited Alzheimer’s Network (DIAN) met in Los Angeles on July 13, they heard from their at-risk fellow travelers (see Part 1 of this series), learned how their tissue donations continue to advance ...

DIAD: Families from Argentina, Canada, Minnesota Rally a Global Community

CONFERENCE COVERAGE 2019-08-02 Conference Coverage “One day you will tell your story of how you’ve overcome what you are going through now, and it will become part of someone else’s survival guide.” Luciana, 29, DIAN participant. “The disease might lie inside us, but so does the cure.” ...

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