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Refining Models of Amyloid Accumulation in Alzheimer’s Disease

CONFERENCE COVERAGE 2016-08-29 Conference Coverage The knowledge that Alzheimer’s disease begins with a preclinical phase that lasts for 20 years or more has focused researchers’ minds on prevention. However, they need to know more about how fast pathology progresses, how to predict ...

Raw Deal: Lose Ataxin, Gain BACE

RESEARCH NEWS 2019-08-29 Research News CAG trinucleotide repeat expansions in the ataxin-1 gene cause spinocerebellar ataxia type 1, a fatal neurodegenerative disease. Curiously, variants of this same gene, sans trinucleotide repeat expansions, associate with risk for Alzheimer’s ...

Technology Brings Dementia Detection to the Home

CONFERENCE COVERAGE 2019-08-30 Conference Coverage The past decade has seen increasing use of technology in dementia research. Computer games that provide cognitive training have become part of prevention studies, and trialists are working to move cognitive testing out of the clinic ...

Smart Homes Open Doors to Insights into Aging, Dementia

CONFERENCE COVERAGE 2019-08-30 Conference Coverage Replicating existing paper-and-pencil tests on tablets or smartphones is one thing (Part 13 of this series), but what about taking technology itself to the next level? What are the prospects for continuously collecting information on ...

Can Induced Neurons Identify Early Signs of Neurodegeneration?

CONFERENCE COVERAGE 2019-09-07 Conference Coverage Researchers have linked dozens of genetic loci to late-onset Alzheimer’s disease and found dozens more that cause familial forms of AD and other neurodegenerative diseases. Teasing out how each contributes to pathology has proven a ...

Colombian Cohort Delivers Data on Blood NfL

CONFERENCE COVERAGE 2019-08-08 Conference Coverage At the Alzheimer’s Association International Conference, held July 14–18 in Los Angeles, a blood test indicating that neurons in the brain are degenerating generated considerable buzz. Eric Reiman, Banner Alzheimer’s Institute, Phoenix ...

NGF Gene Therapy Trial Data Published

RESEARCH NEWS 2018-03-29 Research News Two years ago, investigators announced mixed results of a small, Phase 2 trial of a gene therapy aimed at nurturing the survival of at-risk cholinergic neurons in people with AD. While brain injections of CERE-110, an adeno-associated virus ...

Results of Ladostigil Trial Published

RESEARCH NEWS 2019-09-13 Research News In a second Phase 2 strikeout, the small-molecule drug ladostigil missed its primary endpoint of curbing progression from mild cognitive impairment to AD, though people on a low-dose regimen did have less brain shrinkage over three years ...

Phase 3 Trial Suggests Pimavanserin Assuages Psychosis in Dementia

RESEARCH NEWS 2019-09-18 Research News A Phase 3 trial of pimavanserin was halted early when the study met its primary endpoint of delaying relapse to psychosis in people with dementia, according to a press release  by its sponsor, Acadia Pharmaceuticals. Pimavanserin —a ...

Mutant Tau Stiffens Axon Cytoskeleton Near Soma

RESEARCH NEWS 2019-09-20 Research News Changes to the microtubule-binding protein tau cause it to fall off these struts and aggregate, forming neurofibrillary tangles. But is that the reason for tau toxicity? A study in the September 18 Neuron suggests that V337M tau, a variant ...

LRRK Watchers’ Eyes Turn to Inflammation, Autophagy, Kinase

CONFERENCE COVERAGE 2013-03-22 Conference Coverage Read a PDF of the entire series. With variants that boost risk for both familial and sporadic Parkinson’s disease, the LRRK2 gene beckons as a prime target for therapy development. But there’s a hitch: No one knows yet how leucine-rich ...

Could Greasing the Wheels of Lipid Processing Treat Alzheimer’s?

CONFERENCE COVERAGE 2019-04-24 Conference Coverage ApoE4 impairs how the brain handles lipids. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 27–31 in Lisbon, Portugal, researchers argued that this effect of AD’s biggest risk gene is important ...

TOM1: A Check on Runaway Inflammation in Alzheimer’s?

RESEARCH NEWS 2019-10-11 Research News Inflammation serves a purpose, but when it goes unchecked it can cause irreparable damage. On September 30 in Proceedings of the National Academy of Sciences, scientists led by Frank LaFerla and Rodrigo Medeiros at the University of ...

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