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Ribosomal Protein Spurs Faulty Translation of Nucleotide Repeats

RESEARCH NEWS 2019-08-02 Research News A GGGGCC hexanucleotide repeat expansion in intron 1 of the C9ORF72 gene causes familial amyotrophic lateral sclerosis and frontotemporal dementia. Aberrant translation of this expansion results in toxic poly-dipeptides that build up in the ...

High and Low Hemoglobin Levels Tied to Alzheimer’s

RESEARCH NEWS 2019-08-02 Research News A study that followed more than 12,000 people for over 12 years adds significant weight to the idea that hemoglobin level is an important risk factor for Alzheimer’s and other dementias. Scientists led by M. Arfan Ikram at Erasmus Medical ...

ASOs: Wave of the Future in Alzheimer’s Therapeutics?

CONFERENCE COVERAGE 2019-08-02 Conference Coverage When participants in the Dominantly Inherited Alzheimer’s Network (DIAN) met in Los Angeles on July 13, they heard from their at-risk fellow travelers (see Part 1 of this series), learned how their tissue donations continue to advance ...

DIAD: Families from Argentina, Canada, Minnesota Rally a Global Community

CONFERENCE COVERAGE 2019-08-02 Conference Coverage “One day you will tell your story of how you’ve overcome what you are going through now, and it will become part of someone else’s survival guide.” Luciana, 29, DIAN participant. “The disease might lie inside us, but so does the cure.” ...

Rare Luck: Two Copies of ApoE2 Shield Against Alzheimer’s

CONFERENCE COVERAGE 2019-08-08 Conference Coverage Mention ApoE and Alzheimer’s, and the conversation turns to the E4 allele, the strongest susceptibility gene for the disease. But ApoE has another side, in ApoE2. Though this isoform protects against AD, scientists have barely studied ...

Genetics Propels DIAN Toward Therapies

CONFERENCE COVERAGE 2019-08-02 Conference Coverage Each year, the DIAD family conference held in advance of the Alzheimer's Association International Conference features a science update, and this year the focus was on genetics. DIAN families know that the modern era of Alzheimer ...

Expression, Expression, Expression—Time to Get on Board with eQTLs

CONFERENCE COVERAGE 2019-04-19 Conference Coverage Next-generation genetic analysis has opened the floodgates to a wave of new gene discovery. Whole-exome and-genome sequencing have nearly doubled the number of previously known Alzheimer’s genes (see Part 1 of this story). But modern ...

Parsing How Alzheimer’s Genetic Risk Works Through Microglia

CONFERENCE COVERAGE 2019-04-23 Conference Coverage Much of the genetic risk of Alzheimer’s disease plays out in microglia. But exactly how do risk variants change these cells? At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 27–31 in Lisbon, ...

Crenezumab Update: Baseline Data from Colombian Prevention Trial

CONFERENCE COVERAGE 2019-08-08 Conference Coverage A subset of the world’s largest known kindred of autosomal-dominant Alzheimer’s disease, near the Colombian city of Medellin, have enrolled in the Banner Alzheimer Prevention Initiative Autosomal Dominant Alzheimer’s Disease trial. It ...

Paper Alert: MS4A Variants May Sway Alzheimer’s Risk Via TREM2

RESEARCH NEWS 2019-08-15 Research News Variants in the MS4A gene cluster influence AD risk, at least in part, by tweaking levels of another AD risk factor, TREM2. In a study published in Science Translational Medicine on August 14, researchers co-led by Bruno Benitez, Celeste ...

Move Over Aβ, CSF P-Tau Tells Us There’s Plaque in the Brain

CONFERENCE COVERAGE 2019-08-20 Conference Coverage Just as labs around the globe are racing to start marketing plasma Aβ tests, along come new contenders to rattle the field. At this year’s AAIC, held July 14-18 in Los Angeles, scientists reported that certain amino acids on the ...

Why Bother With Round Robins on Blood Tests? Q&A with Kaj Blennow

CONFERENCE COVERAGE 2019-08-21 Conference Coverage At the AAIC conference held July 14–18 in Los Angeles, Kaj Blennow of the University of Gothenburg had his hands full trying to get researchers in the field engaged in the nitpicky drudgery of validation, standardization, and ...

Synaptic Proteins in CSF: New Markers of Cognitive Decline?

CONFERENCE COVERAGE 2019-08-22 Conference Coverage Plasma tests for Aβ and phospho-tau may have stolen the show at this year’s Alzheimer’s Association International Conference, held July 14-18 in Los Angeles, but proteomic and synaptic markers were not that far behind. A neural ...

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